Kaurane-type diterpenoids from Chromoleana odorata, their X-ray diffraction studies and potent α-glucosidase inhibition of 16-kauren-19-oic acid

Wafo, Pascal; Kamdem, Ramsay S.T.; Ali, Zulfıqar; Anjum, Shazia; Begum, Afshan; Ogbole, Omonike O.; Khan, Shafqat Ullah; Ngadjui, Bonaventure T.; Etoa, Xavier; Choudhary, M. Iqbal

doi:10.1016/j.fitote.2011.02.003

Cited by 20 publications

(14 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C. odorata or Siam weed is a scrambling perennial shrub which grows to 2-3 m in height with straight, pithy, brittle stems that branch readily. Phytochemical analysis has shown that C. odorata contains flavonoids 10 , terpenoids 11 , alkaloids 12 , essential oils 13 , tannins, and saponins 14 . The traditional uses or phytochemical properties of C. odorata are anticancer 15 , antidiabetic 16 , anti-inflammatory 17 , antimicrobial 18 , and antioxidant activities…”

Section: Introductionmentioning

confidence: 99%

Artemia salina Lethality and Histopathological Studies of Siam Weed, Chromolaena odorata

Sirinthipaporn

Jiraungkoorskul

2017

JNR

View full text Add to dashboard Cite

Siam weed, Chromolaena odorata, leaves, stem, and root were extracted with aqueous and ethanol solvents within 1, 3, 5 and 24 hours. The extractions were determined amount of total phenolic compound using Folin-Ciocalteu reagent. The extract that showed the highest amount of total phenolic compound was used for evaluating the cytotoxicity test against Artemia salina at varying concentrations as 0, 50, 500, 5,000 and 50,000 ppm. The cytotoxicity data were determined the median and 90% lethal concentration, LC50 and LC90, respectively, within 24 hours. The result revealed that the highest amount of total phenolic compound was 198.02+3.96 mg of gallic acid equivalent per gram of aqueous leaf extraction in 24 h. Therefore, the 24-hour aqueous extract of C. odorata leaf expressed the 24-h LC50 and LC90 values in A. salina were 43, 551 and 78,391 ppm, respectively. The lesions were observed in intestinal parts such as edema, deformation or elongation of the enterocytes, blebbing cells, and pyknotic cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Artemia salina Lethality and Histopathological Studies of Siam Weed, Chromolaena odorata

Sirinthipaporn

Jiraungkoorskul

2017

JNR

View full text Add to dashboard Cite

show abstract

“…Recently, a labdane type diterpene (spicatanol) isolated from the rhizomes of Hedychium spicatum showed α-glucosidase inhibitory activities but with a higher IC 50 value of 34.1 µM 37 . Another new diterpenoid, 15-angeloyloxy-16,17-epoxy-19-kauronic acid along with its known metabolite 16-kauren-19-oic acid isolated from the roots of Chromoleana odorata, exhibited strong α-glucosidase inhibitory activities 38 . Two new icetexane diterpenes-8,11,13-icetexatriene-10-hydroxy,11,12,16-triacetoxyl and 8,11,13-icetexatriene-7,10,11-dihydroxy-12,13-dihydrofuran isolated from the roots of Premna tomentosa displayed intestinal α-glucosidase inhibitory activities 39 .…”

Section: Discussionmentioning

confidence: 99%

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

Mukherjee¹,

Sengupta²

2012

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

“…[23] Its active phytochemical substances are as follows: (1) flavonoid aglycones (flavanones, flavonols, flavones) including acacetin, chalcones, eupatilin, luteolin, naringenin, kaempferol, quercetin, quercetagetin, and sinensetin;[2425262728293031] (2) terpenes and terpenoids;[32] (3) essential oils;[333435363738] (4) alkaloids including pyrrolizidine;[394041] (5) saponins and tannins;[23] (6) phenolic acids including ferulic acid, protocatechuic acid;[42] (7) phytoprostane compound including chromomoric acid. [43]…”

Section: Phytochemical Substancesmentioning

confidence: 99%

Wound healing property review of siam weed, Chromolaena odorata

Sirinthipaporn¹,

Jiraungkoorskul²

2017

Phcog Rev

View full text Add to dashboard Cite

Chromolaena odorata (Family: Asteraceae) synonyms as Eupatorium odoratum is a traditional medicinal plant that is widely used for its wound healing property. In particular, the several parts of this herb have been used to treat wounds, burns, and skin infections. Furthermore, it has also been shown to possess anticancer, antidiabetic, anti-hepatotoxic, anti-inflammatory, antimicrobial, and antioxidant properties. Its phytochemical components are alkaloids, flavonoids, flavanone, essential oils, phenolics, saponins, tannins, and terpenoids. The other important constituents of this plant are Eupolin, chromomoric acid, quercetagetin, and quercetin, all of which contribute to its remedial properties. Published information on the wound healing property of C. odorata was gathered by the use of different scientific websites such as Google Scholar, Science Direct, PubMed, and Web of Knowledge to provide an up-to-date review showing its importance.

show abstract

Kaurane-type diterpenoids from Chromoleana odorata, their X-ray diffraction studies and potent α-glucosidase inhibition of 16-kauren-19-oic acid

Cited by 20 publications

References 14 publications

<I>Artemia salina</I> Lethality and Histopathological Studies of Siam Weed, <I>Chromolaena odorata</I>

<I>Artemia salina</I> Lethality and Histopathological Studies of Siam Weed, <I>Chromolaena odorata</I>

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

Wound healing property review of siam weed, Chromolaena odorata

Contact Info

Product

Resources

About