It is wel known that the homeland of the Melon (Cucumis melo), which is a one-year reptile body, belonging to the Cucurbitaceae family, is Asia. Iran, Caucasus, Turkey, Afghanistan and melon species that are encountered in the wild in Turkistan form and is believed that it was spread to the world from the regions concerned. Melon fly, Myiopardalis pardalina (Bigot, 1891) (Diptera:Tephrtidae) is one of the most important pests in melon grown areas in the Southeastern Anatolia Region. When the melon approximately reaches the size of a hazelnut, the larvae hatched from the eggs that have been left by the female in the fruit shell feed on the flesh and move towards the house of fruit seed with the tunnels they open, leading to various damages. Such damaged melons are not preferred by consumers. Moreover, invincible losses decrease the commercial market value of melon. In this research, data related to different methods of struggle of melon fly which has caused significant economic losses in Southeastern Anatolia region were obtained in the nature conditions. This study was carried out in Diyarbakır Province Çınar District Şükürlü Village (Diyarbakır city, Turkey) in 2018-2019 under field conditions. Four melon varieties (Balhan, Balözü, VT21B and the local variety Winter melon "sliced" local genotype "VN2136") were taken into the experiment and designed with 3 replications. In order to determine the damage rate of the melon fly, 100 fruits were checked in each melon variety parcel. Control procedures were carried out weekly, counts were made and continued until the end of the season. Fruits with dishes were removed from the application plots. In the experiment studies carried out to identify the number of holes in the melon fruits, it was detected that there was no difference when considering the hole number between Balözü, Balhan, Local (winter melon "sliced" local genotype "VN2136") and VT21 melon varieties. when the data collected from this study were under analysis it was revealed that, the lowest number of holes was found in Domestic (Winter melon "sliced" local genotype "VN2136") melon varieties, and the highest hole number was found in Balözü melon variety. In this study, the damage rates of melon fly on some melon varieties were determined.