Keeping Your Patient With Heart Failure Safe

Amabile, Celene M; Spencer, Anne P.

doi:10.1001/archinte.164.7.709

Cited by 59 publications

(10 citation statements)

References 85 publications

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“…[239][240][241][242] The onset of these findings occurred typically after years of long-term administration, and the valve abnormalities did not completely resolve on drug discontinuation. 243 The mechanism of the valve fibrosis is thought to be related to excess serotonin activity because both methysergide and ergotamine are partial serotonin agonists. 242 With the advent of newer agents to acutely treat migraines (eg, triptans), both methysergide and ergotamine should be avoided.…”

Section: Antimigraine Medicationsmentioning

confidence: 99%

Drugs That May Cause or Exacerbate Heart Failure

Page¹,

O’Bryant²,

Cheng³

et al. 2016

Circulation

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359

185

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Heart failure is a common, costly, and debilitating syndrome that is associated with a highly complex drug regimen, a large number of comorbidities, and a large and often disparate number of healthcare providers. All of these factors conspire to increase the risk of heart failure exacerbation by direct myocardial toxicity, drug-drug interactions, or both. This scientific statement is designed to serve as a comprehensive and accessible source of drugs that may cause or exacerbate heart failure to assist healthcare providers in improving the quality of care for these patients.

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Section: Antimigraine Medicationsmentioning

confidence: 99%

Drugs That May Cause or Exacerbate Heart Failure

Page¹,

O’Bryant²,

Cheng³

et al. 2016

Circulation

Self Cite

359

185

View full text Add to dashboard Cite

show abstract

“…The classes of drugs most commonly associated with DRPs include those prescribed for cardiovascular, nervous and, alimentary tract and metabolic systems [3][4][5]. During hospitalisation there are often changes to patients' long established drug regimens, and so patients are at increased risk of DRPs occurring in the period after discharge [6].…”

Section: Introductionmentioning

confidence: 99%

“…number of diseases per patient in discharge summaries: 4.1 ± SD 2.9 (range 1-11); and in HMR reports: 4.7 ± SD 2.6 (range [1][2][3][4][5][6][7][8][9][10][11][12]. A total of 398 drug related problems were identified for 71 (93.3%) patients with mean 5.6 ± SD 4.3 problems (range .…”

mentioning

confidence: 99%

Drug related problems after discharge from an Australian teaching hospital

et al. 2010

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This study showed that patients recently discharged from a tertiary care hospital had a significant number of drug related problems. Classification of drugs and diseases revealed a broad range of non-cardiovascular medicines and conditions in the patients from an acute care cardiology unit. We found that home medicines review provided continuity of care and an opportunity for medication reconciliation which revealed marked differences in number of drugs, between hospital discharge and medicines review. The patients' uncertainly about their drugs and their diverse range of co-morbidities indicated the need for timely counselling by pharmacists in the community.

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“…Nifedipine reduces systemic vascular resistance and has a neurohumoral effect and a negative inotropic and chronotropic effect. [16,30] Nifedipine, contrary to NSAID and TZD, may be beneficial to HF patients with preserved ejection fraction (HFpEF). In fact, guidelines recommend that blood pressure has to be treated optimally among patients with HFpEF to help relax the ventricle.…”

Section: Discussionmentioning

confidence: 99%

“…Among dihydropyridine CCBs, only nifedipine was considered as there is evidence of contra-indications in heart failure only for that drug. [16] We searched for a claim for a contra-indicated drug class in the 365 days before HF diagnosis and between HF diagnosis and the event date. We selected the claim closest to the event date and then determined the exposure time period by adding 1.5 times the number of days’ supply to this last claim date.…”

Section: Methodsmentioning

confidence: 99%

Effect of contraindicated drugs for heart failure on hospitalization among seniors with heart failure

et al. 2017

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Little is known about the effect of nonsteroidal anti-inflammatory drugs (NSAIDs), thiazolidinediones (TZDs), nifedipine and nondihydropyridine calcium channel blockers (CCBs) usage on the risk of all-cause hospitalization among seniors with heart failure (HF). We assessed the risk of all-cause hospitalization associated with exposure to each of these drug classes, in a population of seniors with HF.Using the Quebec provincial databases, we conducted a nested case-control study in a population of individuals aged ≥65 with a first HF diagnosis between 2000 and 2009. Patients were considered users of a potentially inappropriate drug class if their date of hospital admission occurred in the interval between the date of the last drug claim and the end date of its days’ supply. The risks of hospitalization were estimated using multivariate conditional logistic regression.Of the 128,853 individuals included in the study population, 101,273 (78.6%) were hospitalized. When compared to nonusers, users of NSAIDs (adjusted odds ratio: 1.16; 95% confidence interval: 1.13–1.20), TZD (1.09; 1.04–1.14), and CCBs (1.03; 1.01–1.05) had an increased risk of all-cause hospitalization, but not the users of nifedipine (1.00; 0.97–1.03).Seniors with HF exposed to a potentially inappropriate drug class are at increased risk of worse health outcomes. Treatment alternatives should be considered, as they are available.

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Keeping Your Patient With Heart Failure Safe

Cited by 59 publications

References 85 publications

Drugs That May Cause or Exacerbate Heart Failure

Drugs That May Cause or Exacerbate Heart Failure

Drug related problems after discharge from an Australian teaching hospital

Effect of contraindicated drugs for heart failure on hospitalization among seniors with heart failure

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