Kefoconazofe 2% Emulsion in the Treatment of Seborrheic Dermatitis

Abstract

Fifty patients (42 men, 8 women) with seborrheic dermatitis were included in the trial. Ketoconazole 2% emulsion or the same emulsion without active drug was applied b.i.d. for 4 weeks. Two patients dropped out in the ketoconazole group and nine in the placebo group. Pityrosporum ovale was cultured from all patients at the start and from six out of 23 in the ketoconazole group versus nine out of 16 in the placebo group at week 4. The overall assessment showed a significantly better response to treatment for the ketoconazole emulsion (72%) than for the placebo (32%).

In vitro Activity of Lithium Succinate against <i>Malassezia furfur</i>

“…Although the exact mechanism remains to be proved, the pathogenic role of M. furfur in these skin disor ders is more and more accepted now. The successful use of antimycotics, especially ketoconazole, in the treatment of seborrheic dermatitis and dandruff confirmed the hypothe sis that M. furfur infection is etiologically important [1][2][3].…”

Seborrheic Dermatitis Today, Gone Tomorrow? The Link between the Biocene and Treatment

“…As frequently found in the literature, ketoconazole is used as the comparator because this drug is undoubtedly one of the most potent agents active on Malassezia-driven diseases [4,8,9,11]. Other antifungals occasionally claim similar efficacy.…”

Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

“…Improvement in the skin condition is accompanied by a reduction in Malassezia spp. colonization of the skin surface [4, 5, 6]. A direct anti-inflammatory effect of KCZ is also part of the mechanisms underlying the efficacy of topical KCZ [7, 8, 9].…”