Keratin 19 protein expression is an independent predictor of survival in human hepatocellular carcinoma

Abstract

Our study confirms the prognostic significance of K19 expression in Caucasian patients with HCCs, providing further evidence that it may be used to stratify HCC according to tumour aggressiveness.

Prognostic value of cytokeratin 19 in hepatocellular carcinoma: A meta-analysis

“…Thirdly, publication bias was found in the meta-analysis with OS and DFS from univariate analysis results. As some studies only provided the survival results in the form of multivariate analysis, some studies did not provide survival results, and one study was excluded due to low methodological assessment score [15], these may account for the publication bias. Finally, only the studies in English and Chinese were included in this meta-analysis though we did not set language limitations during the literature research.…”

“…After the initial screening based on the abstracts or titles, 298 studies were excluded from the analysis, leaving 25 studies available for full-text review. After further reading the fulltext, 8 articles were excluded due to duplication (n = 6), HR with 95% CI unavailable (n = 1) and scoring less than 6 (n = 1) [15]. Eventually, there were 17 studies included in this present meta-analysis [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] (Fig.…”

Hepatic progenitor cells in metastatic liver carcinomas

“…In‐vitro and in‐vivo models in a single study suggested that HPCs may have a marked effect on HCC cells, and appear to stimulate the growth and malignant potential of experimental HCC tumours. With respect to the spatial relationship of HPCs and tumour tissue, oval cells localised inside and outside the carcinomatous foci have been observed in rats, and HPCs have very occasionally been reported in human hepatocellular tumours …”

Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis

“…In normal human liver, hepatocytes typically express keratin (K) 8 and K18, while bile duct cells predominantly express K7 and K19 [3]. In previous studies, a subset of HCC was observed to express K19 [3–10]. Durnez et al [4] showed that K19-positive HCC cells were characterized by an oval nucleus and a narrow rim of cytoplasm, resembling non-neoplastic hepatic progenitor cells.…”