Keratinized Spindle Cell: A Diagnostic Cytological Atypia In Human Oral Carcinoma

Mohanta, Dr Abhimanyu; Mohanty, Dr Prafulla K.; Parida, Dr Gadadhar

doi:10.9790/0853-13847280

Cited by 5 publications

(9 citation statements)

References 23 publications

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“…With regard to the cellular characteristics of normal or control groups, the findings of Latej and Kurteshi [34] contradict results reported earlier by Mohanta et al [35]. However, Latej and Kurteshi concluded that cosmetic facial preparations have an insignificant effect on cellular diameter but a significant effect on nuclear diameter and increased nuclear-to-cytoplasmic ratio; this corroborates the findings of Mohanta et al who worked on human OSCC.…”

Section: Discussioncontrasting

confidence: 45%

“…Recorded atypical cells for the [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] year age group of 4 males and one female were 12 and 12, respectively, for the palate, values which were very high in comparison with other sites. For the 50-69 year age group 6 cells from a single male and 16 from 2 females were scored.…”

Section: Cells (Ksc-a)mentioning

confidence: 99%

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Keratinized strap cells: a rare cytological atypia resembles Anitschkow cells, in human oral neoplasm

2015

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Section: Discussioncontrasting

confidence: 45%

Section: Cells (Ksc-a)mentioning

confidence: 99%

Keratinized strap cells: a rare cytological atypia resembles Anitschkow cells, in human oral neoplasm

2015

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“…Bi-nucleated and multinucleated KTCs were also observed in the stain ed cytosmears (Figs. [7][8]. It is important to note that exceptionally in 3 (2.21 per cent) cases, the nuclei were observed to be extended up to the tip of the tail.…”

Section: Resultsmentioning

confidence: 97%

Keratinized Tadpole Cells in Human Oral Neoplasm: A Cytodiagnostic Approach

Mohanta¹,

Mohanty²,

Parida³

2014

IOSRJDMS

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Background: Use of exfoliative cytology and cyto-analysis is a useful early diagnostic method for epithelial atypia and for human oral neoplasm. A rare occurrence of cytological atypia appeared to be anuran tadpole larva, named as keratinized tadpole cell (KTC) is analyzed cytomorphometrically with a cytodiagnostic approach. Materials and Methods: In a case-control study, exfoliated scraped cytosmears were collected from the affected sites of the clinically diagnosed 136 oral cancer patients over the pre-cleaned microslides and immediately fixed in acetoalcohol. Cytosmears were stained with routine Papanicolaou's stain and counterstained with the Giemsa's solution. One thousand cells were observed and the KTCs were scored from each stained sample following standard criteria. Findings were statistically analyzed, interpreted and correlated with the oral sites, sex and nature of addiction. Results: Keratinized tadpole cells (KTCs) exhibit both cytological and nuclear pleomorphism. Almost all KTCs are moderately differentiated with a well defined head and tail in each. Usually, nucleus is confined to the head part of the cell and tail contains cytoplasm only. Keratinized cytoplasm, nuclear pleomorphism, presence of nuclear haloes, micronucleation, multinucleation and increased nuclear-cytoplasmic ratios (N/C) in keratinized tadpole cells are the clear indication of malignancy so far as cytopathology is concerned. Conclusion: Appearance of KTCs in the epithelia of oral neoplasm has a practical utility in early detection and diagnosis of the oral cancer patients.

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“…It has been observed that number of MNCs were observed to be in increasing order with increase in degree of pathogenicity where as the number of PKSCs were found to be in decreasing order gradually [20]. In some of the leukoplakia cases few Keratinized spindle cells (KSC) [21] and Keratinized tadpole cells (KTC) [22] were also observed. Similarly, in erythroplakia stage, few more cytological atypias, like Keratinized tadpole cells (KTC) and Keratinized strap (Anitschkow) cells (KSC-A) [23] were found.…”

Section: Nuclear Pleomorphismmentioning

confidence: 91%

“…In KFCs, the nuclei were drastically modified and found to be fibre like elongated. The nuclear-cytoplasmic (N/C) ratios in these cytological atypias were previously reported to be in increased state in comparison to their normal counter-part [18][19][20][21][22][23][24][25].…”

Section: Nuclear Pleomorphismmentioning

confidence: 99%

Nuclear pleomorphism-based cytopathological grading in human oral neoplasm

Mohanta¹,

Prafulla²

2017

Russ. Open Med. J.

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Objective -The objective of the present study is record the nuclear pleomorphism in various stages of oral carcinogenesis and to analyse their utility in cytopathological grading for early detection of human oral cancer Material and Methods -In this hospital based case-control study, oral site, age-group and sex-matched 272 subjects (136 cases and 136 normal healthy individuals) were included. Scraped exfoliated cytosmears were collected from the affected oral site of the subjects and smearing was done in the pre-cleaned-coded glass-slides. Two such slides were prepared from each subject. The cytosmears were immediately fixed in aceto-alcohol (1 part of glacial acetic acid: 3 part of absolute ethyl alcohol) fixative. One set of the slide was stained with Papanicolaou's stain and the other set was counter-stained with Giemsa's Solution for cytopathological analysis. Test of proportion (ztest) was followed and the critical ratio (z-value) was calculated for the test of significance. Results -Nuclear pleomorphism in the form of round, oval, spindle, elongated fiber as well as irregular shapes were mostly observed in oral squamous cells during different stages of carcinogenesis. Appearance of such nuclear pleomorphism in human oral neoplasm may be considered as a sign of cellular alternation in general and index of oral carcinogenesis in particular. In the present study, the frank malignant cases mimic to be either premalignant lesions or benign/carcinoma in situ were detected on the basis of nuclear pleomorphismbased cytopathological grading and so an increasing trend was observed from precancerous lesions to malignant cases due to shifting of numbers. Diagnostic tests also indicated that the Sensitivity was calculated to be 83.5%, Specificity was 100%, positive predictive value (PPV) was 100%, negative predictive value (NPV) was 30% and the accuracy was found to be 84.6%. Therefore, the nuclear pleomorphismbased cytopathological grading system makes itself an ideal screening test for early detection of human oral cancer. Conclusion -Pattern of nuclear pleomorphism corresponding to various cytological atypias is a common feature observed during different stages of oral carcinogenesis and thus, it has a practical implication in grading and early detection of oral cancer.

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Keratinized Spindle Cell: A Diagnostic Cytological Atypia In Human Oral Carcinoma

Cited by 5 publications

References 23 publications

Keratinized strap cells: a rare cytological atypia resembles Anitschkow cells, in human oral neoplasm

Keratinized strap cells: a rare cytological atypia resembles Anitschkow cells, in human oral neoplasm

Keratinized Tadpole Cells in Human Oral Neoplasm: A Cytodiagnostic Approach

Nuclear pleomorphism-based cytopathological grading in human oral neoplasm

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