Ketamine-based analgosedation for dressing changes in burn patients

Deniau, Benjamin; Mallet, Vincent; Tymowski, Christian de; Dépret, François

doi:10.1097/eja.0000000000001702

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…Ketamine should be used with caution in critical care patients. 45 Liver test monitoring is mandatory for ketamine dose ≥1,000 mg. Ketamine should be considered as a potential culprit when investigating causes of cholangitis (or of abnormal liver tests) in critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury

De Tymowski,

Dépret,

Dudoignon

et al. 2024

JHEP Reports

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Section: Discussionmentioning

confidence: 99%

Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury

De Tymowski,

Dépret,

Dudoignon

et al. 2024

JHEP Reports

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“…We would like to thank Deniau and colleagues 1 for their interest in our article. 2 They raise several issues regarding Ketamine total dose (mg)…”

Section: Editormentioning

confidence: 97%

“…We would like to thank Deniau and colleagues 1 for their interest in our article 2 . They raise several issues regarding the use of ketamine and the potential risk of secondary sclerosing cholangitis (SSC).…”

mentioning

confidence: 99%

Reply to: Ketamine-based analgosedation for dressing changes in burn patients

Swami

McClune

Black

et al. 2022

European Journal of Anaesthesiology

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“…Ketamine medical use has been associated with hepatobiliary complications, which is well established in the literature [ 9 , 10 ]. Burned patients who receive large accumulative doses of ketamine are more prone to develop these complication [ 11 , 12 ]. Recently, critically ill patients with coronavirus disease 2019 (COVID-19) have also been afflicted with biliary tract diseases such as secondary sclerosing cholangitis [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Features of biliary tract diseases in ketamine abusers: a systematic review of case reports

Teymouri,

Nasoori,

Fakheri

et al. 2024

J Med Case Reports

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Background and aims Anesthesiologists prefer ketamine for certain surgeries due to its effectiveness as a non-competitive inhibitor of the N-methyl-D-aspartate receptor in the brain. Recently, this agent has also shown promise as an antidepressant. However, ketamine can cause hallucinogenic effects and is sometimes abused as an illicit drug. Ketamine abuse has been associated with liver and bile duct complications. This systematic study aims to better understand cholangiopathy in ketamine abusers by reviewing case reports. Methods and material In this systematic review, a comprehensive literature search was conducted with the terms “biliary tract diseases” and “ketamine”. Case reports and case series of adult patients with documented ketamine abuse and reported cholangiopathy or biliary tract disease were included. We extracted the data of relevant information and the results were reported through narrative synthesis and descriptive statistics. Results A total of 48 studies were initially identified, and 11 studies were finally included in the review. The mean age of the patients was 25.88 years. Of the 17 patients, 64.7% were men. Symptoms often included abdominal pain, nausea, and vomiting. Most patients were discharged with improved symptoms and liver function. Common bile duct dilation and other findings were observed in imaging results and other diagnostic studies. Conclusion This review highlights the diverse presentations and diagnostic modalities used in ketamine-induced cholangiography. These patients tend to be young men with deranged liver function tests and abdominal pain, which should be taken into consideration. These patients often require a multidisciplinary approach in their management.

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Ketamine-based analgosedation for dressing changes in burn patients

Cited by 3 publications

References 7 publications

Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury

Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury

Reply to: Ketamine-based analgosedation for dressing changes in burn patients

Features of biliary tract diseases in ketamine abusers: a systematic review of case reports

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