“…23 We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] In recent years, our group has also focused on the applications of name reactions in the total synthesis of natural products containing nitrogen heterocycles, showing diverse biological activities.…”
Section: Introductionmentioning
confidence: 99%
“…[25][26][27][28][29][30][31][32][33] We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] In recent years, our group has also focused on the applications of name reactions in the total synthesis of natural products containing nitrogen heterocycles, showing diverse biological activities. [34][35][36][37][38][39][40][41][42] Armed with these experiences, in this review we try to highlight the medical usages and selected synthetic pathways of approved and market purchasable prescribed medications, containing nitrogen based-heterocycles.…”
In this review, we try to present a comprehensive overview on top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways.
“…23 We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] In recent years, our group has also focused on the applications of name reactions in the total synthesis of natural products containing nitrogen heterocycles, showing diverse biological activities.…”
Section: Introductionmentioning
confidence: 99%
“…[25][26][27][28][29][30][31][32][33] We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] In recent years, our group has also focused on the applications of name reactions in the total synthesis of natural products containing nitrogen heterocycles, showing diverse biological activities. [34][35][36][37][38][39][40][41][42] Armed with these experiences, in this review we try to highlight the medical usages and selected synthetic pathways of approved and market purchasable prescribed medications, containing nitrogen based-heterocycles.…”
In this review, we try to present a comprehensive overview on top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways.
“…We are interested in heterocyclic chemistry and their asymmetric synthesis . We have recently reviewed the applications of DA and HDA reactions in the total synthesis of natural products ,.…”
Asymmetric hetero-Diels-Alder (AHDA) reactions provide a multitude of opportunities for the highly efficient, regio- and stereoselective construction of various heterocycles in enantiomerically pure form. The asymmetric aza-Diels-Alder (A-aza-DA) reaction using diversely hetero-dienophiles and hetero-dienes have been increasingly developed as a valuable method for the synthesis of functionalized nitrogen ring systems. The purpose of this review is to give a detailed discussion of the A-aza-DA reaction particularly, the stereoselective reactions of imines as dienophiles with Dainshefsky dienes to obtain optically pure aza-Diels-Alder products. The development of stereoselective variants of the reaction make use of imines as the dienophile and Dainshefsky dienes is at the forefront of these studies. This review updates the A-aza-DA reactions covering the literature from 1972 till date.
“…Also we are interested in heterocyclic chemistry [24][25][26][27][28][29][30][31] and more focused on nitrogen heterocycles such as pyrimidine [32,33] and 1,2,4-triazines [34]. There are two main important concepts in heterocyclic chemistry, tautomerism and regioselectivity.…”
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