Ketoprofen gel improves low back pain in addition to IV dexketoprofen: a randomized placebo-controlled trial

The therapeutic management of back pain with and without sciatica in the emergency department: a systematic review

“…Findings from this review that NSAIDs are as effective alone than when combined with other pharmacology (23,26,27,38,39) are consistent with the recommendations of others (40,41). It is recommended that oral NSAIDs should be considered first in the ED management of patients with back pain and that the addition of opioids or muscle relaxants do not significantly affect painrelieving qualities (40).…”

“…Methodological quality is summarised in Tables 3 and 4. Study scores ranged from 16 to 31 with a mean score of 24 out of a possible 32 and given corresponding quality levels: excellent (27)(28)(29)(30)(31)(32), good (21)(22)(23)(24)(25)(26), fair (15)(16)(17)(18)(19)(20) and poor (<15) adapted from previously documented ratings (13).…”

“…Sealed opaque envelopes were used to conceal randomisation in nine studies (14,(16)(17)(18)(19)(20)(21)(22). Identical or labelled syringes or masked tablets were provided immediately after randomisation by the pharmacist in seven studies (23)(24)(25)(26)(27).…”

“…N=2 (17,20) found corticosteroids to be beneficial in LBP with sciatica, but not LBP without sciatica. When considering the use of oral and topical non-steroidal anti-inflammatory drugs (NSAIDs) in the management of LBP without sciatica n=3 studies (23,24,26) found Naproxen to be superior alone when compared to combination pharmacotherapy, the addition of paracetamol to ibuprofen compared to ibuprofen alone did not improve outcomes after one week (34), and n=1 study found the application of Ketoprofen gel in addition to intravenous (IV) Dexketoprofen to be superior to placebo (27). IV Dexketoprofen NSAID) was as effective as IV Paracetamol and IV Morphine in patients with LBP without neurological deficit (19) in n=1 study.…”

Analysis of Factors Related to Length of Stay Time in Patients with Back Pain at Emergency Department

“…Barksdale et al [10] reported that the nurses of the emergency department were trained in pain classification and applied it to reduce the starting time of pain control for the patients who were visiting because of various pains. In addition, in the study comparing the results of various combinations of painkillers to acute non-traumatic back pain patients, the combination of painkillers and the prognosis of the patient was not related, however, regardless of the degree of pain, the early administration of painkillers helps the patient to control pain quickly, it was reported that even gel-type rubon painkillers were effective [11,12]. In the our study, painkillers were administered to all back pain patients, and the time required to administer the painkillers was significantly shorter in patients in the less than 3 hours group.…”