Key molecules involved in the Th17/Treg balance are associated with the pathogenesis of reflux esophagitis and Barrett’s esophagus

Liu, Juan; Luo, Yao; Wang, Jun; Xi, Chunhui; Chen, Yú; Yang, Guodong; Ling, Ying

doi:10.1007/s10388-020-00773-2

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…Compared with patients with high-grade dysplasia of Barrett’s esophagus, the abundance of Firmicutes in patients with Barrett’s esophagus increases significantly in those with non-dysplasia and low-grade dysplasia ( Park and Lee, 2020 ). Liu J. et al. (2021) confirmed that the abundance of Firmicutes is negatively correlated with RORγt, but positively correlated with FoxP3.…”

Section: Discussionsupporting

confidence: 57%

“…(2021) confirmed that the abundance of Firmicutes is negatively correlated with RORγt, but positively correlated with FoxP3. RORγt and FoxP3 are important transcription factors for Th17 and Treg cells, respectively ( Liu J. et al., 2021 ). An increase in the number of Th17 cells and a decrease in Treg cells are also observed in patients with RE ( Liu J. et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…RORγt and FoxP3 are important transcription factors for Th17 and Treg cells, respectively ( Liu J. et al., 2021 ). An increase in the number of Th17 cells and a decrease in Treg cells are also observed in patients with RE ( Liu J. et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Helicobacter pylori Infection on the Oral Microbiota of Reflux Esophagitis Patients

Liang

Liu

et al. 2021

Front. Cell. Infect. Microbiol.

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The human oral microbiota plays a vital role in maintaining metabolic homeostasis. To explore the relationship between Helicobacter pylori (Hp) and reflux esophagitis, we collected 86 saliva samples from reflux esophagitis patients (RE group) and 106 saliva samples from healthy people (C group) for a high-throughput sequencing comparison. No difference in alpha diversity was detected between the RE and the C groups, but beta diversity of the RE group was higher than the C group. Bacteroidetes was more abundant in the RE group, whereas Firmicutes was more abundant in the C group. The linear discriminant analysis effect size analysis demonstrated that the biomarkers of the RE group were Prevotella, Veillonella, Leptotrichia, and Actinomyces, and the biomarkers of the C group were Lautropia, Gemella, Rothia, and Streptococcus. The oral microbial network structure of the C group was more complex than that of the RE group. Second, to explore the effect of Hp on the oral microbiota of RE patients, we performed the 14C-urea breath test on 45 of the 86 RE patients. We compared the oral microbiota of 33 Hp-infected reflux esophagitis patients (REHpp group) and 12 non-Hp-infected reflux esophagitis patients (REHpn group). No difference in alpha diversity was observed between the REHpn and REHpp groups, and beta diversity of the REHpp group was significantly lower than that of the REHpn group. The biomarkers in the REHpp group were Veillonella, Haemophilus, Selenomonas, Megasphaera, Oribacterium, Butyrivibrio, and Campylobacter; and the biomarker in the REHpn group was Stomatobaculum. Megasphaera was positively correlated with Veillonella in the microbial network of the REHpp group. The main finding of this study is that RE disturbs the human oral microbiota, such as increased beta diversity. Hp infection may inhibit this disorderly trend.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Effects of Helicobacter pylori Infection on the Oral Microbiota of Reflux Esophagitis Patients

Liang

Liu

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Moreover, Han et al [ 74 ] showed that Tregs may have the highest interleukin (IL)-32 expression in the TME of ESCC patients, and this expression is positively correlated with that of Foxp3, potentially promoting tumor progression; in addition, IL-32 may also induce interferon (IFN)-γ secretion by CD8 + T cells and facilitate antitumor immunity. Additionally, an imbalance in Th17/Treg cells has also been reported to occur during the development of Barrett’s esophagus, the precursor of EAC, through the regulation of the release of certain inflammatory cytokines[ 75 ].…”

Section: Dysfunction Of Immune Cellsmentioning

confidence: 99%

Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer

Zhang,

Yu,

Zhao

et al. 2024

World J Gastroenterol

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As a highly invasive malignancy, esophageal cancer (EC) is a global health issue, and was the eighth most prevalent cancer and the sixth leading cause of cancer-related death worldwide in 2020. Due to its highly immunogenic nature, emer-ging immunotherapy approaches, such as immune checkpoint blockade, have demonstrated promising efficacy in treating EC; however, certain limitations and challenges still exist. In addition, tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment (TIME); thus, understanding the TIME is urgent and crucial, especially given the im-portance of an immunosuppressive microenvironment in tumor progression. The aim of this review was to better elucidate the mechanisms of the suppressive TIME, including cell infiltration, immune cell subsets, cytokines and signaling pathways in the tumor microenvironment of EC patients, as well as the downregulated expression of major histocompatibility complex molecules in tumor cells, to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of immunotherapies. Therefore, personalized treatments could be developed to maximize the advantages of immunotherapy.

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IL-8, TNF-α, and IL-17 in the Development of Erosive Esophagitis and Symptom Perception in Gastroesophageal Reflux Disease (GERD)

Sugihartono,

Hidayat,

Alfaray

et al. 2024

JCM

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Background: The diverse clinical characteristics of erosive esophagitis (EE) and symptom perception in patients with gastroesophageal reflux disease (GERD) remain a major challenge in understanding their underlying pathogenesis. This study aimed to investigate the association between the levels of IL-8, TNF-α, and IL-17 in serum and the presence of erosive esophagitis and symptoms related to GERD. Method: We enrolled 65 subjects presenting with GERD symptoms. Based on the findings of upper endoscopy, the subjects were categorized into two groups: (1) erosive esophagitis (EE LA grades B-D) and (2) non-erosive esophagitis (normal-EE LA grade A). Symptom perception was assessed via GERD questionnaire (GERD-Q) and the frequency scale for the symptoms of GERD (FSSG). The enzyme-linked immunosorbent assay (ELISA) method was used to analyze serum levels of IL-8, TNF-α, and IL-17. Analysis of cytokine levels between different symptoms severity was performed using the Kruskal-Wallis H test. Results: Median serum IL-8 levels were significantly higher in the erosive esophagitis group compared to those with non-erosive esophagitis (20.2 (IQR 16.9–32.2) vs. 17.7 (IQR 15.2–19.6), p < 0.05). The study found a significant association between IL-8 levels and the presence of globus symptoms (median IL8 level 46.961 (38.622–92.644) in subjects with globus vs. 18.06 (16.68–20.49) in those without globus; p < 0.05). Similarly, TNF-α levels were associated with the frequency of regurgitation symptoms (H index = 10.748; dr = 3; p < 0.05). We observed a significant correlation between IL-17 levels and the frequency of heartburn and early satiety symptoms. Conclusions: IL-8 may play a role in the development of mucosal erosion in GERD. IL-8, TNF- α, and IL-17 might be involved in the development of globus symptoms, the frequency of regurgitation, and the frequency of heartburn and early satiety, respectively. The diverse symptom phenotypes observed in patients with GERD symptoms may be mediated by distinct profiles of proinflammatory cytokines.

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Key molecules involved in the Th17/Treg balance are associated with the pathogenesis of reflux esophagitis and Barrett’s esophagus

Cited by 3 publications

References 39 publications

Effects of Helicobacter pylori Infection on the Oral Microbiota of Reflux Esophagitis Patients

Effects of Helicobacter pylori Infection on the Oral Microbiota of Reflux Esophagitis Patients

Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer

IL-8, TNF-α, and IL-17 in the Development of Erosive Esophagitis and Symptom Perception in Gastroesophageal Reflux Disease (GERD)

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