Key points in effective inhaler technique training for asthma and COPD patients

Ohbayashi, Hiroyuki

doi:10.17352/ojpp.000014

Open J Pharmacol Pharmacother 2020

DOI: 10.17352/ojpp.000014

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Key points in effective inhaler technique training for asthma and COPD patients

Hiroyuki Ohbayashi¹

Abstract: Main textMajor therapeutic guidelines for asthma and chronic obstructive pulmonary disease (COPD), including the Global Initiative for Asthma (GINA) and Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, recommend inhalation medications as the fi rst-line treatment for these obstructive pulmonary diseases [1,2]. However, patient adherence to inhaled drugs is generally poorer than adherence to oral medications [3,4]. Why is this? The answer lies in the method by which inhalation therapy i… Show more

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Cited by 3 publications

References 16 publications

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Comparison of User Satisfaction and Preference with Inhalant Devices Between a Pressurized Metered-Dose Inhaler and Ellipta in Stable Asthma Patients: A Randomized, Crossover Study

Ohbayashi¹,

Asano²,

Kudo³

et al. 2021

Pulm Ther

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Introduction Inhalation therapy involves two types of adherence: adherence to the drug and adherence to the procedures for the inhalation device. User satisfaction and preference are key factors for maintaining good adherence of both types, and they should be evaluated based on three conditions being well maintained: asthma control level (ACL), adherence, and adequate device operability during usage duration. We compared user satisfaction and preference between a pressurized metered-dose inhaler (pMDI) and a dry powder inhaler (Ellipta), while maintaining the three conditions during usage in stable asthma patients. Methods In this open-label, randomized, two-way crossover study, patients with stable asthma [Asthma Control Questionnaire (ACQ) scores < 0.75] were classified into a 20–64-year age group (G1) and a ≥ 65-year age group (G2) and randomly assigned to either a formoterol/fluticasone combination (FFC) as the pMDI group or a vilanterol/fluticasone combination (VFC) as the Ellipta group. Satisfaction and preference levels were evaluated at week 4. ACL was measured using the ACQ and Japan Asthma Control Survey questionnaires at weeks 0 and 4. Device operability and respiratory resistance were also examined. Results Forty-four patients (23 G1, age 45.8 ± 1.9 years; 21 G2, 74.1 ± 1.3 years) were enrolled and maintained good ACL during the study. Adherence to FFC pMDI and VFC Ellipta was > 97% in all groups. Device operability did not differ significantly between FFC pMDI and VFC Ellipta in the G1 (p = 0.189) or G2 (p = 0.506) group. Overall satisfaction was marginally higher with the FFC pMDI than with the VFC Ellipta in G2 (p = 0.012) but non-significantly different in G1 (p = 0.733). Factors affecting overall satisfaction in G2 were difference of inhalation device and body mass index. Respiratory resistance did not change significantly over the study in G2. Conclusion Based on maintaining good ACL, adherence, and device operability, FFC pMDI showed significantly higher satisfaction and preference levels than VFC Ellipta in elderly persons. Trial Registration Japan Registry of Clinical Trials identifier, jRCTs041180001 (registered 21 August 2018).

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Comparison of User Satisfaction and Preference with Inhalant Devices Between a Pressurized Metered-Dose Inhaler and Ellipta in Stable Asthma Patients: A Randomized, Crossover Study

Ohbayashi¹,

Asano²,

Kudo³

et al. 2021

Pulm Ther

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Assessment of groundwater quality and alkaline earth metals from the Al Masaraat basin at Al Dhahirah Governorate, Sultanate of Oman

Al Hatmi,

Embong,

Gismelseed

2024

International Journal of Environmental Analytical Chemistry

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Visualization of the obscure inhalation stage in inhalation therapy

Hiroyuki

2023

Int J Pharm Sci Dev Res

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The flow of the inhalation procedure during inhalation therapy can be divided into three successive stages: a pre-inhalation preparatory stage, a drug inhalation stage, and a post-inhalation stage. Among these, the second stage, drug inhalation, is the most important and obscure. Using ambiguous verbal expression, the drug inhalation method is communicated to the patient using terms such as strongly, deeply, and slowly. Patients usually determine their optimal method of drug inhalation device independently, based on their own interpretation and understanding of the verbal instructions. This may make the precise inhalation using an inhalation device unpredictable. The Tokico Inhalation Monitor TM (TIM) was developed to resolve the unpredictability of this second (drug inhalation) stage. The TIM can simultaneously measure the inhalation flow rate, duration, and total volume, and display them on the screen in real-time. This mini-review demonstrates the effects of inhalation instruction using TIM, which allows the second stage of therapy, drug inhalation, to be displayed on a screen in real-time.

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Key points in effective inhaler technique training for asthma and COPD patients

Cited by 3 publications

References 16 publications

Comparison of User Satisfaction and Preference with Inhalant Devices Between a Pressurized Metered-Dose Inhaler and Ellipta in Stable Asthma Patients: A Randomized, Crossover Study

Comparison of User Satisfaction and Preference with Inhalant Devices Between a Pressurized Metered-Dose Inhaler and Ellipta in Stable Asthma Patients: A Randomized, Crossover Study

Assessment of groundwater quality and alkaline earth metals from the Al Masaraat basin at Al Dhahirah Governorate, Sultanate of Oman

Visualization of the obscure inhalation stage in inhalation therapy

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