Key process features of personalized diet counselling in metabolic syndrome: secondary analysis of feasibility study in primary care

Background Substantial variability in response to lifestyle interventions has been recognized for many years, and researchers have begun to disentangle sources of error from inherent differences in individual responsiveness. The objective of this secondary analysis of an intensive lifestyle intervention (diet and exercise) for metabolic syndrome (MetS) was to identify potentially important differences among study completers grouped by treatment response as measured by change in a continuous metabolic syndrome score (Gurka/MetS). Methods All study completers from a 12-month primary care study were categorized into one of five groups according to change in the Gurka/MetS score. A change of 0.4 in z-score defined clinically relevant change in line with results of previous studies. Repeated measures analysis of variance was used to examine cardiovascular disease risk and individual clinical indicators of MetS over 12 months, looking for differences in response over time by the five groups. Results Of 176 participants, 50% ( n = 88) had stable scores, 10% ( n = 18) had relevant change scores in the first 3 months only and reverted toward baseline, 20% ( n = 35) achieved meaningful change over the whole study, 11% ( n = 20) had a delayed response at 3–12 months, and 9% ( n = 15) demonstrated worsening scores. Significant differential patterns were noted for groups over the duration of the intervention ( p < .001). Improvement in diet quality and fitness scores were similar across all groups. Other available variables were tested and did not account for the differences. Conclusion Work is needed to identify key factors that account for differences in responses to lifestyle interventions that can be used to guide treatment decisions for intensive lifestyle interventions for this common condition. Trial Registration ClinicalTrials.gov Identifier: NCT01616563; first registered June 12, 2012. Supplementary Information The online version contains supplementary material available at 10.1186/s12875-024-02608-w.

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Exploratory Analysis of the Variable Response to an Intensive Lifestyle Change Program for Metabolic Syndrome

Maitland,

Brauer,

Mutch

et al. 2023

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Background Wide variability in response to lifestyle interventions has been recognized for many years, and researchers have begun to disentangle sources of error from inherent differences in individual responsiveness. The objective of this secondary analysis of an intensive lifestyle intervention (diet and exercise) for metabolic syndrome (MetS) was to identify potentially important differences among study completers grouped by treatment response as measured by change in a continuous metabolic syndrome (Gurka/MetS) score. Methods All study completers from a 12-month primary care study were categorized into one of five groups according to change in the Gurka/MetS score. A change of 0.4 in z-score defined clinically relevant change in line with results of previous studies. Repeated measures analysis of covariance was used to examine the Gurka/MetS score over 12 months, looking for differences in response over time by the five groups. Results Of 176 participants, 50% (n = 88) had stable scores, 10% (n = 18) had relevant change scores in the first 3 months only and reverted toward baseline, 20% (n = 35) achieved meaningful change over the whole study, 11% (n = 20) had a delayed response at 3–12 months, and 9% (n = 15) demonstrated worsening scores. Significant response group*time differences were noted (p < 0.001). Improvement in diet quality and fitness scores were similar across all groups. Available other variables did not account for the differences. Conclusion Work is needed to identify key factors that account for differences in responses to lifestyle interventions that can be used to guide treatment decisions for intensive lifestyle interventions for this common condition. Trial Registration ClinicalTrials.gov Identifier: NCT01616563; first registered June 12, 2012.

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Key process features of personalized diet counselling in metabolic syndrome: secondary analysis of feasibility study in primary care

Cited by 3 publications

References 95 publications

A Data-Driven Methodology and Workflow Process Leveraging Research Electronic Data Capture (REDCap) to Coordinate and Accelerate the Implementation of Personalized Microbiome-Based Nutrition Approaches in Clinical Research

A Data-Driven Methodology and Workflow Process Leveraging Research Electronic Data Capture (REDCap) to Coordinate and Accelerate the Implementation of Personalized Microbiome-Based Nutrition Approaches in Clinical Research

Exploratory analysis of the variable response to an intensive lifestyle change program for metabolic syndrome

Exploratory Analysis of the Variable Response to an Intensive Lifestyle Change Program for Metabolic Syndrome

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