Key role for VSMCs in vascular remodeling and calcification

Abstract

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“…These differentiated VSMCs subsequently produce macrocalcification deposits and calcified plaques causing a gradual decrease in arterial compliance (Durham et al, 2018;Tyson et al, 2020). In order to prevent spontaneous calcification, inhibitors of calcification are present in the circulation and in the vasculature, including fetuin-A, matrix Gla protein (MGP), osteoprotegerin, pyrophosphate and osteopontin (Bäck et al, 2018;Jaminon, 2020).…”

“…Moreover, reduced endothelial NO production might influence the regulation of VSMCs tone (Chirinos et al, 2019). Under pathological conditions, ECs produce cytokines and grow factors which induce VSMCs phenotype switching from a contractile to a more synthetic state (Jaminon, 2020).…”