2021
DOI: 10.56499/jppres20.951_9.3.333
|View full text |Cite
|
Sign up to set email alerts
|

Khat-drug interactions: A systematic review

Abstract: Context: Consumption of khat leaves has been disseminated worldwide with the migration of its users from Arabia and Africa. Despite numerous reports regarding the associations of khat chewing with serious health impacts, a significant number of people worldwide uses khat daily, especially in its origin countries. The risk of co-administration of khat and drugs (prescription and over the-counter medications) is high among these individuals, leading to increase probability of adverse khat-drug interactions. The … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
2
0

Year Published

2021
2021
2022
2022

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 25 publications
0
2
0
Order By: Relevance
“…Besides cathinone, khat contains other less psychoactive components including cathine S,S-(+)-norpseudoephedrine, R,S-(-)-norephedrine, catheduline and cathidine [24] , [27] . After the young leaves matures, cathinone is metabolised into cathine and norephedrine [6] . Older khat leaves are lacking in cathinone but they have less active cathine and norephedrine [38] .…”
Section: Introductionmentioning
confidence: 99%
“…Besides cathinone, khat contains other less psychoactive components including cathine S,S-(+)-norpseudoephedrine, R,S-(-)-norephedrine, catheduline and cathidine [24] , [27] . After the young leaves matures, cathinone is metabolised into cathine and norephedrine [6] . Older khat leaves are lacking in cathinone but they have less active cathine and norephedrine [38] .…”
Section: Introductionmentioning
confidence: 99%
“…It causes pancreatic beta cells to release insulin, delays gastric emptying, prevents beta cell glucagon release, and creates a sensation of satiety (Nasri & Rafieian-Kopaei, 2014). There are few studies about the effects of khat chewing on clinical drugs (Albaser et al, 2021). For our knowledge, this is first study about effect of khat chewing on metformin, which was a preliminary study to evaluate the effect of khat (Catha edulis Forsk) chewing on serum Random Blood Sugar (RBG) level in Type 2 Diabetic Mellitus (T2DM) patients treated with metformin.…”
Section: )mentioning
confidence: 99%
“…Khat chewing may be associated with increased risk of cardiovascular and blood coagulation disorders. It also may interfere with absorption , metabolism and mechanism action of some orally administered drugs [1][2][3][4]. Khat contains on glycosides and tannis in khat in addition to the alkaloids namely phenylalkaminens cathine (norpseudoephedrine) and cathinone {S(-)-alphaaminopropiaphenone)}that have amphetamine like effect [6,7].…”
Section: Introductionmentioning
confidence: 99%