KHF16 is a Leading Structure from <i>Cimicifuga foetida</i> that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway

Kong, Yanjie; Li, Fubin; Nian, Yin; Zhou, Zhongmei; Yang, Runxiang; Qiu, Ming‐Hua; Chen, Ceshi

doi:10.7150/thno.14694

Cited by 34 publications

(24 citation statements)

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“…Several cycloartane triterpenoids isolated from C. yunnanensis were also shown to induce apoptosis of breast cancer cells via p53-dependent mitochondrial pathway 10 . Most recent findings demonstrated that cycloartane triterpenoids isolated from C. foetida could inhibit Raf/MEK/ERK signaling pathway and Akt phosphorylation in breast cancer MCF-7 cells 11 , as well as suppress TNFα-induced IKKα/β and IKBα phosphorylation, and nuclear factor (NF)-κB downstream target gene expression in triple-negative breast cancer cells 12 .…”

mentioning

confidence: 99%

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

Yue

Xie

Lee

et al. 2016

Sci Rep

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Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida (Chinese herb “shengma”) which could inhibit the growth of breast cancer cells. Nevertheless, the effect of actein on angiogenesis, which is an essential step for tumor growth and metastasis, has never been reported. Hence, this study aimed to investigate the in vitro and in vivo effects of actein on angiogenesis using human microvascular endothelial cells (HMEC-1), matrigel plug and tumor-bearing mouse models. Our results showed that actein significantly inhibited the proliferation, reduced the migration and motility of endothelial cells, and it could suppress the protein expressions of VEGFR1, pJNK and pERK, suggesting that JNK/ERK pathways were involved. In vivo results showed that oral administration of actein at 10 mg/kg for 7 days inhibited blood vessel formation in the growth factor-containing matrigel plugs. Oral actein treatments (10–15 mg/kg) for 28 days resulted in decreasing mouse 4T1 breast tumor sizes and metastasis to lungs and livers. The apparent reduced angiogenic proteins (CD34 and Factor VIII) expressions and down-regulated metastasis-related VEGFR1 and CXCR4 gene expressions were observed in breast tumors. Our novel findings provide insights into the use of actein for development of anti-angiogenic agents for breast cancer.

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confidence: 99%

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

Yue

Xie

Lee

et al. 2016

Sci Rep

Self Cite

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“…[57][58][59][60] A variety of NPs reduce the expression levels of survivin and XIAP in different cancers. 61,62 Pue in Z138 51 cells, which further activate caspase-3 and −9, as shown in Table 1 and Figure 2.…”

Section: Survivin and X-linked Inhibitor Of Apoptosis Protein (Xiap) mentioning

confidence: 88%

<p>Molecular Mechanisms of Anticancer Activities of Puerarin</p>

Ahmad¹,

Khan²,

Liu³

et al. 2020

CMAR

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Medicinal plants are a vital source of natural products (NPs) that can cure cancer through modulation of different pathways, including oxidative stress, extrinsic and intrinsic apoptosis, cell cycle, inflammation, NF-kB, PI3K/AKT/mTOR, AMPK (JNK), MEK/ERK (Raf)-MEK-ERK and autophagy. Puerarin (Pue), an important NP belonging to the isoflavone glycoside group, is derived from Pueraria lobata (Willd.) Ohwi, Pueraria thomsonii Benth, and Pueraria tuberosa (Willd.). This NP was approved by the Chinese Ministry of Health for the treatment of different diseases in 1993, but it was also later reported to exhibit anticancer activity. Pue causes cancer cells death through modulation of different mechanisms including oxidative stress, intrinsic and extrinsic, Survivin and XIAP, PI3K/AKT/ mTOR, Ras-Raf-MEK-ERK, JNK, cell cycle, AMPK, NF-kB, inflammation and autophagy pathways. Therefore, this review compiles for the first time the studies about the anticancer mechanism of Pue and provides comprehensive information about the anticancer effects of Pue. This review may serve as a basis for future research and clinical treatment.

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“…Few in vitro tests using breast cancer cell lines in culture and in vivo animal studies evaluating the effect of black cohosh as chemopreventive or anticancer agents are reported in literature. Several components extracted from black cohosh were tested in human breast cancer cells revealing anticancer properties: cycloartane triterpenoids induced mitochondrial apoptosis and cell cycle arrest, via Raf/MEK/ERK signalling pathway and Akt phosphorylation [ 343 ] or via NF- κ B signalling pathway [ 344 ]. Actein revealed an antiangiogenic effect by inhibiting the proliferation and reduced the migration and motility of endothelial cells ( in vitro ).…”

Section: Phytotherapymentioning

confidence: 99%

Phytotherapy and Nutritional Supplements on Breast Cancer

Lopes

Dourado²,

Oliveira

2017

BioMed Research International

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Breast cancer is the most frequent type of nonskin malignancy among women worldwide. In general, conventional cancer treatment options (i.e., surgery, radiotherapy, chemotherapy, biological therapy, and hormone therapy) are not completely effective. Recurrence and other pathologic situations are still an issue in breast cancer patients due to side effects, toxicity of drugs in normal cells, and aggressive behaviour of the tumours. From this point of view, breast cancer therapy and adjuvant methods represent a promising and challenging field for researchers. In the last few years, the use of some types of complementary medicines by women with a history of breast cancer has significantly increased such as phytotherapeutic products and nutritional supplements. Despite this, the use of such approaches in oncologic processes may be problematic and patient's health risks can arise such as interference with the efficacy of standard cancer treatment. The present review gives an overview of the most usual phytotherapeutic products and nutritional supplements with application in breast cancer patients as adjuvant approach. Regardless of the contradictory results of scientific evidence, we demonstrated the need to perform additional investigation, mainly well-designed clinical trials in order to establish correlations and allow for further validated outcomes concerning the efficacy, safety, and clinical evidence-based recommendation of these products.

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KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway

Cited by 34 publications

References 50 publications

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

<p>Molecular Mechanisms of Anticancer Activities of Puerarin</p>

Phytotherapy and Nutritional Supplements on Breast Cancer

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