Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer

Ishida, Hideyuki; Miwa, Hideaki; Tatsuta, Masayuki; Masutani, Seizo; Imamura, Hiroshi; Shimizu, Junzo; Ezumi, Kiyoshi; Kato, Hitoshi; Kawasaki, Takatoshi; Furukawa, Hiroshi; Kawakami, Hajime

doi:10.1016/j.canlet.2003.10.032

Cited by 44 publications

(34 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With regard to Ki-67, this study showed a statistically significant correlation between immunohistochemical expression of this protein and recurrence (P = 0.035). This result is in agreement with Ishida et al (14) , whose study showed that, even though the use of Ki-67 as a predictive factor for survival in cases of primary tumors is limited, its proliferative activity was significant in relation to the appearance of lymph node and hepatic metastases. In colorectal cancer, high levels of Ki-67 have been correlated with poor survival.…”

Section: Discussionsupporting

confidence: 92%

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Menezes

Júca

Gomes

et al. 2010

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -Search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancer -Objective -To analyze the immunoexpression of the proteins p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors. Method -Tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissue resected from 82 patients who had undergone surgery but not chemotherapy or radiotherapy, at "Hospital São Paulo", São Paulo, SP, Brazil, between 2002 and 2005. Thin sections (4 μm) were subjected to immunohistochemical reactions, and immunoexpression staining scores were obtained. The scores were correlated with the degree of cell differentiation, staging, disease-free interval, recurrence, survival and specific mortality. The study variables were analyzed using the chi-square and Kaplan-Meier tests to investigate associations with the markers. The significance of the differences between the curves of the diseasefree interval and survival was analyzed using the Logrank and Wilcoxon tests. Results -The immunohistochemical expression of p53 was positive in 70 tumors (85.4%) and negative in 12 (14.6%). The expression of bcl-2 was positive in 26 (31.7%) and negative in 56 (68.3%). The expression of Ki-67 was positive in 62 (75.6%) and negative in 20 (24.4%). There was no statistically significant correlation between the expressions of these markers separately or in conjunction, in relation to the degree of cell differentiation, staging, disease-free interval, survival and specific mortality. In relation to recurrence, there was a statistically significant correlation with positive expression of Ki-67 (P = 0.035). Conclusion -The immunohistochemical expression of Ki-67 in colorectal cancer is associated with recurrence of this disease. HEADINGS -Colorectal neoplasms. Adenocarcinoma. Immunohistochemistry. Tumor suppressor protein p53. Proto-oncogene proteins c-bcl-2. Bcl-2 homologous antagonist-killer protein.

show abstract

Section: Discussionsupporting

confidence: 92%

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Menezes

Júca

Gomes

et al. 2010

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…It could be shown that high Ki-67 antigen expression in liver and lymph node metastasis correlated with a poor prognosis (Petrowsky et al 2001;Ishida et al 2004). Considering colorectal tissue itself, some authors concluded that colorectal carcinomas with low pKi-67 expression had a poor prognosis (Palmqvist et al 1999;Allegra et al 2003;Dziegel et al 2003), whereas others found that those cases showing a high pKi-67 expression had a worse prognosis (Kimura et al 2000;Duchrow et al 2001a).…”

Section: Discussionmentioning

confidence: 94%

High-level mRNA quantification of proliferation marker pKi-67 is correlated with favorable prognosis in colorectal carcinoma

Ihmann¹,

Liu

Schwabe³

et al. 2004

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…Although the use of Ki-67 antigen as prognostic marker is quite controversial in CRC, a recent report has demonstrated that, at least for Dukes' C cases, levels of immunohistochemical positivity for this antigen correlate with the clinical outcome of affected patients [26,27].…”

Section: Discussionmentioning

confidence: 97%

Down-regulation of μ-protocadherin expression is a common event in colorectal carcinogenesis

Losi¹,

Parenti²,

Ferrarini³

et al. 2011

Human Pathology

View full text Add to dashboard Cite

Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer

Cited by 44 publications

References 11 publications

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

High-level mRNA quantification of proliferation marker pKi-67 is correlated with favorable prognosis in colorectal carcinoma

Down-regulation of μ-protocadherin expression is a common event in colorectal carcinogenesis

Contact Info

Product

Resources

About