KIBRA gene variants are associated with synchronization within the default-mode and executive control networks

Wang, Dawei; Liu, Bing; Qin, Wen; Wang, Junping; Zhang, Yunting; Jiang, Tianzi; Yu, Chunshui

doi:10.1016/j.neuroimage.2012.12.022

Cited by 20 publications

(24 citation statements)

References 69 publications

(128 reference statements)

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“…2009; Wang et al. 2013). Prior to the functional connectivity analysis, a body of task‐based fMRI evidence has indicated the pivotal role of these regions in executive control (Braver et al.…”

Section: Discussionmentioning

confidence: 99%

“…2009; Wang et al. 2013), indicating general difficulty in mentally activating vision‐related regions. Thus, it seems that the neural activity during imagery in the regions represented by IC15 and IC29 are highly context dependent.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, IC21 was the only component whose fluctuation change was linearly correlated with the subjective report of successful suppression. The human ECN was originally defined by Seeley et al as a dissociable system from the saliency network by inclusion of a MPF region dorsal to the ACC, although there has been some variation in the nomenclature of subcomponents in the following reports (Seeley et al 2007;Christoff et al 2009;Smith et al 2009;Wang et al 2013). Prior to the functional connectivity analysis, a body of task-based fMRI evidence has indicated the pivotal role of these regions in executive control (Braver et al 2003;Dosenbach et al 2007).…”

Section: Imagerymentioning

confidence: 99%

“…Despite consistent recruitment during visual perception, the occipital regions were often outside the regions activated by visual imagery (Christoff et al 2009). Moreover, according to a detailed examination of how the early visual cortices are sometimes not activated by mental imagery, prediction of the visual cortical response in general is not straightforward (Christoff et al 2009 well documented; however, one study reported partial deactivation in the visual cortices during imagery (Christoff et al 2009), and another recent study combining imagery with neurofeedback reported a paradoxical signal decrease in early visual cortices (Seeley et al 2007;Smith et al 2009;Wang et al 2013), indicating general difficulty in mentally activating vision-related regions. Thus, it seems that the neural activity during imagery in the regions represented by IC15 and IC29 are highly context dependent.…”

Section: Visual and Other Networkmentioning

confidence: 99%

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Dynamic interactions of the cortical networks during thought suppression

et al. 2016

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ObjectivesThought suppression has spurred extensive research in clinical and preclinical fields, particularly with regard to the paradoxical aspects of this behavior. However, the involvement of the brain's inhibitory system in the dynamics underlying the continuous effort to suppress thoughts has yet to be clarified. This study aims to provide a unified perspective for the volitional suppression of internal events incorporating the current understanding of the brain's inhibitory system.Materials and MethodsTwenty healthy volunteers underwent functional magnetic resonance imaging while they performed thought suppression blocks alternating with visual imagery blocks. The whole dataset was decomposed by group‐independent component analysis into 30 components. After discarding noise components, the 20 valid components were subjected to further analysis of their temporal properties including task‐relatedness and between‐component residual correlation.ResultsCombining a long task period and a data‐driven approach, we observed a right‐side‐dominant, lateral frontoparietal network to be strongly suppression related. This network exhibited increased fluctuation during suppression, which is compatible with the well‐known difficulty of suppression maintenance.ConclusionsBetween‐network correlation provided further insight into the coordinated engagement of the executive control and dorsal attention networks, as well as the reciprocal activation of imagery‐related components, thus revealing neural substrates associated with the rivalry between intrusive thoughts and the suppression process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Imagerymentioning

confidence: 99%

Section: Visual and Other Networkmentioning

confidence: 99%

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Dynamic interactions of the cortical networks during thought suppression

et al. 2016

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“…SNPs meeting this criterion but with minor allele frequencies <10% were excluded due to too few minor allele carriers in this sample. In addition, eight SNPs in candidate genes were included that have prior evidence from at least two studies for association with SZ intermediate phenotypes, including ERP abnormalities (COMT 33 ), neuropsychological impairments (ERBB4, 37,69,70 MTHFR, 71,72 DISC1, 42 COMT, 69,73 KIBRA, 40 NRG1, 69 GRIN2B 69 ), and structural and functional neuroimaging measures (DTNBP1, 74,75 DISC1, 42,76 NRG1, 76 GRIN2B, 77 ERBB4, 37 COMT, 78 KIBRA 79 ). We identified a total of 21 SNPs meeting these selection criteria (Supplementary Table 1).…”

Section: Methodsmentioning

confidence: 99%

Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds

Bergen

Mesholam-Gately

et al. 2014

Transl Psychiatry

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Several genes have recently been identified as risk factors for schizophrenia (SZ) by genome-wide association studies (GWAS), including ZNF804A which is thought to function in transcriptional regulation. However, the downstream pathophysiological changes that these genes confer remain to be elucidated. In 143 subjects (68 clinical high risk, first episode or chronic cases; 75 controls), we examined the association between 21 genetic markers previously identified by SZ GWAS or associated with putative intermediate phenotypes of SZ against three event-related potential (ERP) measures: mismatch negativity (MMN), amplitude of P300 during an auditory oddball task, and P300 amplitude during an auditory novelty oddball task. Controlling for age and sex, significant genetic association surpassing Bonferroni correction was detected between ZNF804A marker rs1344706 and P300 amplitude elicited by novel sounds (beta=4.38, P=1.03 × 10−4), which is thought to index orienting of attention to unexpected, salient stimuli. Subsequent analyses revealed that the association was driven by the control subjects (beta=6.35, P=9.08 × 10−5), and that the risk allele was correlated with higher novel P300b amplitude, in contrast to the significantly lower amplitude observed in cases compared to controls. Novel P300b amplitude was significantly correlated with a neurocognitive measure of auditory attention under interference conditions, suggesting a relationship between novel P300b amplitude and higher-order attentional processes. Our results suggest pleiotropic effects of ZNF804A on risk for SZ and neural mechanisms that are indexed by the novel P300b ERP component.

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Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults

Qin

Liu

et al. 2015

Brain Struct Funct

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Different genotypic combinations of COMT and DRD2 can generate multiple subgroups with different levels of dopamine signaling. Its modulations on brain properties can be investigated by analyzing the combined gene effects of COMT and DRD2. However, the inherent association between modulation patterns of the dopamine system on structural and functional properties of the brain remains unknown. In 294 healthy young adults, we investigated both additive and non-additive interactions of COMT and DRD2 on gray matter volume (GMV) and resting-state functional connectivity (rsFC) using a voxel-based analysis. We found a significant non-additive COMT × DRD2 interaction in the right dorsal anterior cingulate cortex (dACC), exhibiting an inverted U-shape modulation by dopamine signaling. We also found a significant non-additive COMT × DRD2 interaction in the rsFC between the right dACC and precuneus, displaying a U-shape modulation by dopamine signaling. Moreover, this rsFC was negatively correlated with the GMV of the right dACC. Although the additive interaction did not pass corrections for multiple comparisons, we also found a trend towards an inverse modulation pattern and a negative correlation between the GMV and rsFC of the right inferior frontal gyrus. No genotypic differences were detected in any assessments of the cognition, mood and personality. These findings suggest that healthy young adults without optimal dopamine signaling may maintain their normal behavioral performance via a functional compensatory mechanism in response to structural deficit due to genetic variation.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-015-1134-4) contains supplementary material, which is available to authorized users.

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KIBRA gene variants are associated with synchronization within the default-mode and executive control networks

Cited by 20 publications

References 69 publications

Dynamic interactions of the cortical networks during thought suppression

Dynamic interactions of the cortical networks during thought suppression

Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds

Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults

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