Kicking it up a Notch for the best in show: Scalloped leads Yorkie into the haematopoietic arena

Ferguson, Gabriel B.; Martínez‐Agosto, Julian A.

doi:10.1080/19336934.2015.1055427

Cited by 13 publications

(12 citation statements)

References 41 publications

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“…Yet since crystal cells still differentiate in collier mutant ( i.e., in the absence of the PSC), it was proposed that the few scattered cells expressing Serrate in the CZ might be the ones responsible for their development . Accordingly, it was recently shown that these so‐called ‘lineage‐specifying cells’ (LSCs) activate Notch signaling in neighboring intermediate progenitors to induce crystal cell fate . The expression of Serrate in LSCs depends on the transcriptional coactivator Yorkie (Yki) and its DNA‐binding partner, Scalloped (Sd), the Drosophila homologues of YAP and TEAD, two effectors of the Hippo signaling pathway .…”

Section: Larval Hematopoiesis Under Normal Conditionsmentioning

confidence: 99%

“…This noncanonical activation of Notch is mediated by Sima, the ortholog of mammalian Hypoxia‐Inducible Factor α, which coordinates crystal cell numbers with environmental oxygenation conditions. Along the same line, crystal cell development is controlled by other systemic signals: wasp parasitization (see below) inhibits Serrate expression in LSCs, allowing lamellocytes to differentiate at the expense of crystal cells , while starvation induces crystal cell rupture by activating the JNK signaling pathway . It is worth mentioning too that uncontrolled activation of the prophenoloxidase PPO1 leads to an expansion of the crystal cell lineage .…”

Section: Larval Hematopoiesis Under Normal Conditionsmentioning

confidence: 99%

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Drosophilahematopoiesis under normal conditions and in response to immune stress

et al. 2016

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The emergence of hematopoietic progenitors and their differentiation into various highly specialized blood cell types constitute a finely tuned process. Unveiling the genetic cascades that control blood cell progenitor fate and understanding how they are modulated in response to environmental changes are two major challenges in the field of hematopoiesis. In the last 20 years, many studies have established important functional analogies between blood cell development in vertebrates and in the fruit fly, Drosophila melanogaster. Thereby, Drosophila has emerged as a powerful genetic model for studying mechanisms that control hematopoiesis during normal development or in pathological situations. Moreover, recent advances in Drosophila have highlighted how intricate cell communication networks and microenvironmental cues regulate blood cell homeostasis. They have also revealed the striking plasticity of Drosophila mature blood cells and the presence of different sites of hematopoiesis in the larva. This review provides an overview of Drosophila hematopoiesis during development and summarizes our current knowledge on the molecular processes controlling larval hematopoiesis, both under normal conditions and in response to an immune challenge, such as wasp parasitism.

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Section: Larval Hematopoiesis Under Normal Conditionsmentioning

confidence: 99%

Section: Larval Hematopoiesis Under Normal Conditionsmentioning

confidence: 99%

Drosophilahematopoiesis under normal conditions and in response to immune stress

et al. 2016

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“…Yorkie then interacts with Scalloped to transcriptionally activate Lozenge, which specifies a crystal cell progenitor. The Lozenge positive crystal cell progenitor further turns on Prophenoloxidase to become a mature crystal cell [19]. Another independent investigation of Reimels and Pfleger described a role of Rabex-5 in hemocyte specification.…”

Section: Role Of Notch During Hemocyte Differentiationmentioning

confidence: 99%

Recent Advances in Notch Signaling Pathway in Drosophila: A Snapshot

Mishra¹,

Mukherjee²

2015

Adv Tech Biol Med

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Notch signaling pathway unfolds principal cell communication machinery that plays a vital role in development. It is apparent from several studies that the outcome of Notch signaling is tightly regulated in different cellular context. Notch signaling affects a number of cellular processes at various developmental stages by modulating itself in number of ways to produce different magnitude in the signaling output. It is, therefore, important to understand the context dependent complexity of Notch and various modes of its regulation. This article aims to briefly describe the advances in Notch signaling in Drosophila in the past one year.

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“…Yorkie functions as a transcription co-activator, but its phosphorylation by Warts blocks its function by locking it in the cytoplasm. Yorkie and its binding partner, the transcription factor Scalloped, function together to regulate crystal cell formation in a cell-autonomous manner by transcriptionally activating lz expression in crystal cell progenitors [ 75 ] or in a non-cell-autonomous manner by promoting Ser expression in a subset of cortical area cells to instruct the neighboring Notch-positive cells to commit to the crystal cell fate [ 51 , 77 ]. Insulin signaling and downstream Target of Rapamycin (TOR) signaling are also known to stimulate cell proliferation via dMyc in the PSC [ 78 , 79 , 80 , 81 , 82 ], and are essential for progenitor maintenance [ 78 , 83 , 84 ].…”

Section: Regulatory Signaling During Lymph Gland Developmentmentioning

confidence: 99%

Regulation of Drosophila Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View

Lan

Liu

Zhao

et al. 2020

IJMS

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The Drosophila hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for Drosophila larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled. Multiple developmental signaling pathways, such as Notch, Hedgehog, and Wnt/Wingless, have been demonstrated to regulate the hematopoietic processes in the lymph gland. Focusing on blood cell maintenance and differentiation, this article summarizes the functions of several classic developmental signaling pathways for lymph gland growth and patterning, highlighting the important roles of developmental signaling during lymph gland development as well as Drosophila larval hematopoiesis.

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Kicking it up a Notch for the best in show: Scalloped leads Yorkie into the haematopoietic arena

Cited by 13 publications

References 41 publications

Drosophilahematopoiesis under normal conditions and in response to immune stress

Drosophilahematopoiesis under normal conditions and in response to immune stress

Recent Advances in Notch Signaling Pathway in Drosophila: A Snapshot

Regulation of Drosophila Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View

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