Kidney Cell Cycle Arrest and Cardiac Biomarkers and Acute Kidney Injury Following Angiography: The Prevention of Serious Adverse Events Following Angiography (PRESERVE) Study

Murugan, Raghavan; Boudreaux-Kelly, Monique Y.; Kellum, John A.; Palevsky, Paul M.; Weisbord, Steven D.

doi:10.1016/j.xkme.2022.100592

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…In PRESERVE's biomarker substudies, there was no association between urine AKI biomarkers collected 2–4 hours postangiography and CA-AKI. 9 , 10 However, plasma kidney injury molecule-1 and IL‐18 were higher in patients with CA-AKI compared with those who did not. 9 Furthermore, preangiography cardiac, rather than renal, biomarker elevation was associated with MAKE.…”

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confidence: 98%

“… 9 Furthermore, preangiography cardiac, rather than renal, biomarker elevation was associated with MAKE. 10 It is noteworthy that, unlike the prior study, 8 all PRESERVE patients received precontrast hydration, and most underwent diagnostic, rather than interventional, angiography. The investigators speculated that majority of mild CA-AKI is driven by hemodynamic fluctuations and altered renal perfusion, rather than true RTI.…”

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confidence: 98%

“… 6 , 7 Elevated AKI biomarker levels have been reported after CM exposure. 8 – 11 Although there are no studies that performed an analysis similar to the intensive care unit studies, there are conflicting data.…”

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confidence: 99%

“…The general lack of ATN therefore aligns with the absence of a signal with the AKI biomarkers seen in the PRESERVE patient population. 9 , 10 It also highlights that significant histologic damage may be present despite the absence of a biomarker signal. Although this tubular degeneration may not be “clinically significant” in the short term, this may have an effect on renal functional reserve.…”

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confidence: 99%

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confidence: 98%

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confidence: 98%

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confidence: 99%

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confidence: 99%

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Heterogeneity in the definition of major adverse kidney events: a scoping review

Maeda,

Inokuchi,

Bellomo

et al. 2024

Intensive Care Med

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Acute kidney injury (AKI) is associated with persistent renal dysfunction, the receipt of dialysis, dialysis dependence, and mortality. Accordingly, the concept of major adverse kidney events (MAKE) has been adopted as an endpoint for assessing the impact of AKI. However, applied criteria or observation periods for operationalizing MAKE appear to vary across studies. To evaluate this heterogeneity for MAKE evaluation, we performed a systematic scoping review of studies that employed MAKE as an AKI endpoint. Four major academic databases were searched, and we identified 122 studies with increasing numbers over time. We found marked heterogeneity in applied criteria and observation periods for MAKE across these studies, with some even lacking a description of criteria. Moreover, 13 different observation periods were employed, with 30 days and 90 days as the most common. Persistent renal dysfunction was evaluated by estimated glomerular filtration rate (34%) or serum creatinine concentration (48%); however, 37 different definitions for this component were employed in terms of parameters, cut-off criteria, and assessment periods. The definition for the dialysis component also showed significant heterogeneity regarding assessment periods and duration of dialysis requirement (chronic vs temporary). Finally, MAKE rates could vary by 7% [interquartile range: 1.7-16.7%] with different observation periods or by 36.4% with different dialysis component definitions. Our findings revealed marked heterogeneity in MAKE definitions, particularly regarding component assessment and observation periods. Dedicated discussion is needed to establish uniform and acceptable standards to operationalize MAKE in terms of selection and applied criteria of components, observation period, and reporting criteria for future trials on AKI and related conditions.

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The Pathogenesis, Outcomes and Prevention of Contrast-Associated Acute Kidney Injury

Weisbord,

Palevsky

2024

Reference Module in Biomedical Sciences

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Kidney Cell Cycle Arrest and Cardiac Biomarkers and Acute Kidney Injury Following Angiography: The Prevention of Serious Adverse Events Following Angiography (PRESERVE) Study

Cited by 5 publications

References 33 publications

Intravenous Contrast is Associated with AKI in Patients with Stage 1–3 CKD: Commentary

Intravenous Contrast is Associated with AKI in Patients with Stage 1–3 CKD: Commentary

Heterogeneity in the definition of major adverse kidney events: a scoping review

The Pathogenesis, Outcomes and Prevention of Contrast-Associated Acute Kidney Injury

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