Kidney Dysfunction and Hypertension: Role for Cadmium, P450 and Heme Oxygenases?

Satarug, Soisungwan; Nishijo, Muneko; Lasker, Jerome M.; Edwards, Robert J.

doi:10.1620/tjem.208.179

Cited by 104 publications

(74 citation statements)

References 183 publications

(165 reference statements)

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“…This new discovery provides evidence linking SGLT2 activity in kidneys to the role of the kidneys in blood pressure control, demonstrated in early 1970s (Crowley and Coffman 2014). The enzymes of the cytochrome P450 (CYP) superfamily, especially of the CYP4 family (CYP4A11 and CYP4F2) in human kidneys have also been linked to the role of the kidneys in systemic blood pressure regulation (Satarug et al 2006;Fan et al 2015). The CYP4A11 and CYP4F2 enzymes catalyse ɷ-hydroxylation of the arachidonic acid (Lasker et al 2000) to produce 20-hydroxyeicosatetraenoic acid (20-HETE), involved in regulation of salt balance in the kidney (Wu et al 2014a;Fan et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Satarug

Vesey

Gobé

2017

Tohoku J. Exp. Med.

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104

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Section: Introductionmentioning

confidence: 99%

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Satarug

Vesey

Gobé

2017

Tohoku J. Exp. Med.

Self Cite

104

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“…Many epidemiological studies indicated that Cd may exacerbate the harmful renal effects of diabetes and vice versa [24]. The effects of Pb poisoning in diabetic subjects have been recognised [25].…”

Section: Introductionmentioning

confidence: 99%

Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients

Afridi

Kazi

Brabazon

et al. 2013

Clinica Chimica Acta

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Background: The essential metals, chromium (Cr), magnesium (Mg), manganese (Mn) and zinc (Zn), are necessary for many metabolic processes and their homeostasis is crucial for life. The toxic metals, cadmium (Cd) and lead (Pb), have no beneficial role in human metabolism. The aim of this study was to investigate the levels of Cd, Cr, Mg, Mn, Pb, and Zn in scalp hair samples of type 2 diabetes mellitus patients of both genders, ages ranging from 30 to 50 y, and belong to urban areas of Ireland and Pakistan. For comparison purposes, age matched non-diabetic subjects of both countries were selected as referents. Methods: The concentrations of metals in scalp hair samples were measured by inductively coupled plasma atomic emission spectrophotometer and atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by conventional wet-acid-digestion method and using certified reference materials. Results: The mean values of Cd and Pb were significantly higher in scalp hair samples of both Pakistani and Irish diabetic patients as compared to referents of both countries (P<0.001). In contrast, lower Cr, Mg, Mn, and Zn (P<0.01) concentrations were detected in scalp hair derived from patients with type 2 diabetes versus healthy subjects of both countries. Conclusion: This study showed that, increased toxic elements and decreased essential elements are associated with diabetes mellitus. Therefore, these elements may play a role in the development and pathogenesis of diabetes mellitus.

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“…The effect of Cd on VE-cadherin has been suggested to be involved in the development of atherosclerosis (Pereira et al 2007). The other mechanism of Cd-induced hypertension suggested by Satarug et al (2006) is that Cd deposited in human kidney leads to alterations in metal homeostasis and redox state, changes in gene expression profiles, and ultimately tubular injury. Increased risk of hypertension is found in humans with nephropathy caused by environmental Cd exposure (Satarug et al 2005).…”

Section: Cadmium-induced Cardiovascular Dysfunctionmentioning

confidence: 99%

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

Kukongviriyapan

Apaijit

Kukongviriyapan

2016

Tohoku J. Exp. Med.

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Cadmium (Cd) is a non-essential heavy metal with high toxicity potential. Humans are exposed to Cd present in diet, polluted air, and cigarette smoke. Cd exposure has been associated with increased risk of chronic diseases, including hypertension, atherosclerosis, diabetes, and nephropathy, all of which could be attributable to dysfunctional endothelial and smooth muscle cells. Cd toxicity is correlated with increased reactive oxygen formation and depletion of antioxidants, resulting in an oxidative stress. Chelation of Cd has proved useful in the removal of the Cd burden. However, several chelating agents cause side effects in clinical usage. Recent studies have shown that the antioxidant compounds curcumin and tetrahydrocurcumin can alleviate vascular dysfunction and high blood pressure caused by Cd toxicity. In chronic Cd exposure, these antioxidants protect vascular endothelium by increasing nitric oxide (NO•) bioavailability and improving vascular function. Antioxidant activity against Cd intoxication results directly and/or indirectly through free radical scavenging, metal chelation, enhanced expression of the antioxidant defense system, regulation of inflammatory enzymes, increase in NO• bioavailability, and reduction of gastrointestinal absorption and tissue Cd accumulation. This review summarizes current knowledge of Cd-induced oxidative stress and cardiovascular dysfunction and a possible protective effect conferred by the antioxidants curcumin and tetrahydrocurcumin.

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Kidney Dysfunction and Hypertension: Role for Cadmium, P450 and Heme Oxygenases?

Cited by 104 publications

References 183 publications

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

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