Kidney function and nephrotoxic drug use among older home-dwelling persons with or without diabetes in Finland

Heinjoki, Marjo; Karjalainen, Matti; Saltevo, Juha; Tiihonen, Miia; Haanpää, Maija; Kautiainen, Hannu; Mäntyselkä, Pekka

doi:10.1186/s12882-020-1684-4

Cited by 7 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of DKD increases in parallel with the incidence of DM [ 37 , 38 ]. The pathogenesis of DKD is complex and multifactorial, including genetic and environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Stefanowicz-Rutkowska

Matuszewski

Gontarz-Nowak

et al. 2021

Open Life Sciences

View full text Add to dashboard Cite

Autoimmune thyroid disease (AITD) is more common among diabetes mellitus (DM) patients and may impact its microvascular complications. The present study aimed to assess the relationship between AITD and the prevalence of diabetic kidney disease (DKD) in patients with diabetes mellitus type 1 (DM1). Anthropometric parameters, parameters of metabolic control of DM, thyreometabolic status, and the UACR were assessed. DKD was diagnosed if patients’ UACR level was ≥30 mg/g or eGFR level was <60 mL/min. This study involved 144 patients with DM1 aged 36.2 ± 11.7 years: 49 men and 95 women. Significant differences in creatinine, eGFR, and UACR levels were found in patients with DKD. fT3 concentration was significantly lower among DKD patients. A significantly higher probability of DKD was found in DM1 patients with lower fT3 levels. Patients with DM1 and AITD had significantly lower creatinine levels than the control group. However, the study did not show any significant relationship between AITD and the occurrence of DKD in patients with DM1. Significantly lower fT3 concentrations in DKD patients may be caused by metabolic disorders in the course of DKD and require further cohort studies in a larger population of patients with DM1 and AITD.

show abstract

“…The prevalence of DKD increases in parallel with the incidence of DM [ 37 , 38 ]. The pathogenesis of DKD is complex and multifactorial, including genetic and environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Stefanowicz-Rutkowska

Matuszewski

Gontarz-Nowak

et al. 2021

Open Life Sciences

View full text Add to dashboard Cite

show abstract

“…According to our previous analysis, most of these patients with diabetes had good or at least moderate treatment situation [ 39 ]. In addition, there was not significant difference in renal function between patients with and without diabetes [ 40 ]. Hence, we can assume that the present study patients with diabetes represent those patients who are able to manage at home.…”

Section: Discussionmentioning

confidence: 99%

Use of primary health care services among older patients with and without diabetes

Aro

Karjalainen²,

Tiihonen

et al. 2022

BMC Prim. Care

Self Cite

View full text Add to dashboard Cite

Background The aim of this study was to compare the utilization of primary healthcare services by older patients with and without type 2 diabetes. Methods Electronic patient records were used to identify persons over 65 years of age with a diagnosis of diabetes. Two age- and sex-adjusted controls without diabetes were extracted for each person with diagnosis of diabetes. A health questionnaire was sent by mail to 527 people with diabetes and 890 controls. Of the persons who answered the questionnaire, 518 persons were randomly selected to participate in a health examination. The study group in this analysis consisted of 187 persons with diabetes and 176 persons without diabetes who attended the health examination. The data on primary health care utilization were extracted from electronic patient records one year before and one after the health examination. Results Before the onset of the study, the patients with diabetes had more doctor’s appointments (p < 0.001), nurse’s appointments (< 0.001) and laboratory tests taken (p < 0.001) than those without diabetes After 1-year follow-up period the patients with diabetes had more doctor’s appointments (p = 0.002), nurse’s appointments (p = 0.006), laboratory tests taken (p = 0.006) and inpatient care at the community hospital (p = 0.004) than patients without a diagnosis of type 2 diabetes. The use of the community hospital increased significantly among patients with diabetes (ratio 2.50; 95% Cl 1.16–5.36) but not by patients without diabetes (ratio 0.91; 95% Cl 0.40.2.06). The number of nurse’s appointments increased for patients without diabetes (ratio 1.31; 95% Cl 1.07–1.60) but not for those with diabetes (ratio 1.04; 95% Cl 0.88–1.24). Conclusions Patients with diabetes visit more often physicians and nurses compared with those without diabetes. During a 1-year follow-up, the use of community hospital care increased significantly among patients with diabetes. In addition to focusing on prevention and care of diabetes, these results suggest the importance of diabetes in planning community-based health care services.

show abstract

“…Further, a study conducted in the United States found that RIM was prevalent in 6% of elderly individuals [ 25 ], and a study conducted in Belgium found that 8% of elderly individuals received RIM [ 26 ]. There were only 1 out of 100 older adults living at home in Finland who used drugs with moderate-to-high nephrotoxicity risks [ 27 ].…”

Section: Reviewmentioning

confidence: 99%

Renally Inappropriate Medications in the Old Population: Prevalence, Risk Factors, Adverse Outcomes, and Potential Interventions

AlQashqri

2023

Cureus

View full text Add to dashboard Cite

Like most organs, the renal system decreases in function as we age. In the elderly, chronic kidney disease is common. When patients with chronic kidney disease take nephrotoxic medications, they are more likely to suffer adverse drug reactions, be hospitalized, and spend an extended period in the hospital. Calculating the renal clearance of a drug dose based on its glomerular filtration rate, or creatinine clearance, is necessary. Multiple tools are available for identifying renally inappropriate medications (RIMs). RIM prescriptions can be influenced by various factors, which vary according to the study. A higher number of medications means a higher likelihood of using RIMs. Numerous studies have investigated RIMs. The most contraindicated drug in renal insufficiency patients was a non-steroidal anti-inflammatory medication. A variety of interventions have been used to reduce RIM prescriptions to varying degrees of success.

show abstract

Kidney function and nephrotoxic drug use among older home-dwelling persons with or without diabetes in Finland

Cited by 7 publications

References 33 publications

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Use of primary health care services among older patients with and without diabetes

Renally Inappropriate Medications in the Old Population: Prevalence, Risk Factors, Adverse Outcomes, and Potential Interventions

Contact Info

Product

Resources

About