Kidney

Seely, John C.; Hard, Gordon C.; Blankenship, Brad

doi:10.1016/b978-0-12-391448-4.00011-3

Cited by 13 publications

(16 citation statements)

References 109 publications

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“…In some rodent strains, spontaneous congenital renal cysts or hydronephrosis are not uncommon, but most urinary tract anomalies, in general, are infrequently observed in nonclinical rodent studies. 47 –51 However, urinary tract anomalies in humans represent a much more diverse spectrum of spontaneous malformations which clinically may result in death, CKD, ESRD, hypertension, or remain asymptomatic. 52 -55…”

Section: Upper and Lower Urinary Tract Development During Early Midmentioning

confidence: 99%

Histology Atlas of the Developing Mouse Urinary System With Emphasis on Prenatal Days E10.5-E18.5

et al. 2019

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Congenital abnormalities of the urinary tract are some of the most common human developmental abnormalities. Several genetically engineered mouse models have been developed to mimic these abnormalities and aim to better understand the molecular mechanisms of disease. This atlas has been developed as an aid to pathologists and other biomedical scientists for identification of abnormalities in the developing murine urinary tract by cataloguing normal structures at each stage of development. Hematoxylin and eosin- and immunohistochemical-stained sections are provided, with a focus on E10.5-E18.5, as well as a brief discussion of postnatal events in urinary tract development. A section on abnormalities in the development of the urinary tract is also provided, and molecular mechanisms are presented as supplementary material. Additionally, overviews of the 2 key processes of kidney development, branching morphogenesis and nephrogenesis, are provided to aid in the understanding of the complex organogenesis of the kidney. One of the key findings of this atlas is the histological identification of the ureteric bud at E10.5, as previous literature has provided conflicting reports on the initial point of budding. Furthermore, attention is paid to points where murine development is significantly distinct from human development, namely, in the cessation of nephrogenesis.

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Section: Upper and Lower Urinary Tract Development During Early Midmentioning

confidence: 99%

Histology Atlas of the Developing Mouse Urinary System With Emphasis on Prenatal Days E10.5-E18.5

et al. 2019

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“…( Capen 1996c ; Capen and Rosol 1989 ; Chamanza et al 2010 ; Chandra et al 2013 ; Frith et al 2000 ; Frith and Fetters 1996a ; Hardisty and Boorman 1999 ; Kittel et al 1996a ; Seely and Hildebrand 1990 )…”

Section: Parathyroid Glandmentioning

confidence: 99%

“…( Botts et al 1991 ; Capen and Rosol 1989 ; Frith et al 2000 ; Rosol et al 2013 ; Seely and Hildebrand 1990 ; Wild and Setoguti 1995 )…”

Section: Parathyroid Glandmentioning

confidence: 99%

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Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Brändli-Baiocco

Balme

Bruder³

et al. 2018

J Toxicol Pathol

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the endocrine organs (pituitary gland, pineal gland, thyroid gland, parathyroid glands, adrenal glands and pancreatic islets) of laboratory rats and mice, with color photomicrographs illustrating examples of the lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for endocrine lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“…These areas appear more frequently in kidneys from animals which have died while on study and often have other renal changes recognized by study pathologists relating to post-mortem autolysis such as the loss of cytoplasmic and nuclear detail, and retraction of tubule cells from basement membranes. 11 However, there are uncommon instances where the kidneys are generally well-fixed from sacrificed animals yet have papillary pale areas in one or both kidneys. These pale renal papillary areas are noted in kidneys from control as well as treated animals and appear morphologically similar without notable time or dose progression.…”

mentioning

confidence: 99%

Renal Papillary Rarefaction: An Artifact Mimicking Papillary Necrosis

et al. 2019

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In histopathology, the presence of a tissue change that does not represent the tissue’s normal appearance can often lead to an incorrect diagnosis and interpretation. These changes are collectively known as “artifacts” resulting from postmortem autolysis, improper fixation, problems with tissue handling or slide preparation procedures. Most tissue artifacts are obvious, yet some artifacts may be subtle, occur in relatively well-fixed tissue, and demand careful observation to avoid confusion with real biological lesions. The kidney often contains artifacts that may be observed throughout all regions of the renal parenchyma. Cortical tubule artifacts present the greatest challenge when discerning an artifact versus an induced lesion following exposure to a xenobiotic. However, confounding artifacts observed at the tip of the renal papilla may also be problematic for the pathologist. An uncommon artifact involving tinctorial alteration and rarefaction affecting the papillary tip of the rat kidney is described here and differentiated from treatment induced lesions of renal papillary necrosis.

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Kidney

Cited by 13 publications

References 109 publications

Histology Atlas of the Developing Mouse Urinary System With Emphasis on Prenatal Days E10.5-E18.5

Histology Atlas of the Developing Mouse Urinary System With Emphasis on Prenatal Days E10.5-E18.5

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Renal Papillary Rarefaction: An Artifact Mimicking Papillary Necrosis

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