Kidney plays an important role in ketogenesis induced by risperidone and voluntary exercise in juvenile female rats

Wu, Yi; Sylvester, Emma; Lian, Jiamei; Deng, Chao

doi:10.1016/j.psychres.2021.114196

Cited by 5 publications

(3 citation statements)

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“…Prior studies have also found acylcarnitines levels with abnormalities in the plasma of patients with schizophrenia and familial Mediterranean fever (Kiykim et al, 2016;Cao et al, 2020). Moreover, the regulation of L-carnitine metabolites by antipsychotic drugs has been reported in clinical studies (Lheureux and Hantson, 2009;Molina et al, 2021;Yi et al, 2021), and in animal studies (Albaugh et al, 2012;, particularly in two early studies in patients with schizophrenia after treatment (Kriisa et al, 2017;Cao et al, 2019b). All these findings support our finding that the carnitine pathway can be regulated by OLA.…”

Section: Discussionsupporting

confidence: 90%

Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Discussionsupporting

confidence: 90%

Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric

2024

Frontiers Research Topics

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“…Prior studies have also found acylcarnitines levels with abnormalities in the plasma of patients with schizophrenia and familial Mediterranean fever ( Kiykim et al, 2016 ; Cao et al, 2020 ). Moreover, the regulation of L-carnitine metabolites by antipsychotic drugs has been reported in clinical studies ( Lheureux and Hantson, 2009 ; Molina et al, 2021 ; Yi et al, 2021 ), and in animal studies ( Albaugh et al, 2012 ; Jiang et al, 2019 ), particularly in two early studies in patients with schizophrenia after treatment ( Kriisa et al, 2017 ; Cao et al, 2019b ). All these findings support our finding that the carnitine pathway can be regulated by OLA.…”

Section: Discussionmentioning

confidence: 99%

Carnitine metabolites and cognitive improvement in patients with schizophrenia treated with olanzapine: a prospective longitudinal study

Zhao,

Liu,

Wang

et al. 2023

Front. Pharmacol.

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Objective: Cognitive impairment is one of the core symptoms of schizophrenia, which is stable and lifelong. L-carnitine has been shown to improve cognitive function and decrease the rate of cognitive deterioration in patients with Alzheimer’s disease. However, it remains unclear regarding the role of L-carnitine and its metabolites in cognitive functions in schizophrenia after treatment with olanzapine. The purpose of this study was to evaluate the relationship between changes in plasma levels of L-carnitine metabolites and cognitive improvement after olanzapine treatment.Methods: This was a prospective longitudinal study. In this study, we recruited 25 female patients with first episode schizophrenia (FES) who were drug naïve at baseline and received 4 weeks of olanzapine monotherapy. Cognitive function was assessed at baseline and 4-week follow-up using the RBANS. Plasma L-carnitine metabolite levels were determined by a metabolomics technology based on untargeted ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).Results: We found that the immediate memory index, delayed memory index and RBANS composite score were significantly increased at the 4-week follow-up after treatment. A total of 7 differential L-carnitine metabolites were identified in FES patients after olanzapine monotherapy. In addition, we found that changes in butyrylcarnitine were positively correlated with improvements in language index and RBANS composite score. Further regression analyses confirmed the association between reduced butyrylcarnitine levels and cognitive improvement after olanzapine monotherapy in FES patients.Conclusion: Our study shows that cognitive improvement after olanzapine treatment was associated with changes in L-carnitine metabolite levels in patients with FES, suggesting a key role of L-carnitine in cognition in schizophrenia.

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“…Ketone bodies constitute a family composed of three low-molecular-weight hydro-soluble molecules: acetone (Ac), β-hydroxybutyrate (BHB), and acetoacetate (AcAc), produced mainly by the liver [ 1 ] and to smaller extent by extrahepatic tissues including the intestinal crypts [ 2 , 3 ], kidneys [ 4 ], T cells [ 5 ], and astrocytes [ 6 ]. The capability of these tissues or cell lineages to produce ketone bodies depends on their mitochondrial expression of HMGCS2 (hydroxymethylglutaryl CoA synthase 2), the ketogenic rate-limiting enzyme [ 7 , 8 ] leading to ketone bodies production, using Ac-CoA and AcAc-CoA derived from the beta-oxidation of fatty acids.…”

Section: Introductionmentioning

confidence: 99%

Ketone Bodies as Metabolites and Signalling Molecules at the Crossroad between Inflammation and Epigenetic Control of Cardiometabolic Disorders

Bendridi

Selmi

Balcerczyk

et al. 2022

IJMS

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For many years, it has been clear that a Western diet rich in saturated fats and sugars promotes an inflammatory environment predisposing a person to chronic cardiometabolic diseases. In parallel, the emergence of ketogenic diets, deprived of carbohydrates and promoting the synthesis of ketone bodies imitating the metabolic effects of fasting, has been shown to provide a possible nutritional solution to alleviating diseases triggered by an inflammatory environment. The main ketone body, β-hydroxybutyrate (BHB), acts as an alternative fuel, and also as a substrate for a novel histone post-translational modification, β-hydroxybutyrylation. β-hydroxybutyrylation influences the state of chromatin architecture and promotes the transcription of multiple genes. BHB has also been shown to modulate inflammation in chronic diseases. In this review, we discuss, in the pathological context of cardiovascular risks, the current understanding of how ketone bodies, or a ketogenic diet, are able to modulate, trigger, or inhibit inflammation and how the epigenome and chromatin remodeling may be a key contributor.

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Kidney plays an important role in ketogenesis induced by risperidone and voluntary exercise in juvenile female rats

Cited by 5 publications

References 65 publications

Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric

Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric

Carnitine metabolites and cognitive improvement in patients with schizophrenia treated with olanzapine: a prospective longitudinal study

Ketone Bodies as Metabolites and Signalling Molecules at the Crossroad between Inflammation and Epigenetic Control of Cardiometabolic Disorders

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