Kidney problems in disaster situations

Vanholder, Raymond; Sever, Mehmet Şükrü; Lameire, Norbert

doi:10.1016/j.nephro.2020.02.009

Cited by 16 publications

(8 citation statements)

References 85 publications

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“…RM refers to a clinical syndrome caused by the entry of a large number of intracellular components such as myoglobin (Mb), phosphocreatine kinase, and lactate dehydrogenase into the peripheral blood, which accounts for 13%–50% of cases with AKI ( Cabral et al, 2020 ). The accumulation of Mb in kidney is the core factor leading to kidney injury, and Mb-mediated lipid peroxidation in renal tubular epithelial cells is closely related to glutamate metabolism and can mediate proximal tubular ferroptosis ( Vanholder et al, 2021 ). Guerrero-Hue et al confirmed that ferroptosis was involved in the development of RM-associated AKI, and curcumin could alleviate RM-induced kidney injury via inhibiting ferroptosis of renal tubular epithelial cells ( Guerrero-Hue et al, 2019 ).…”

Section: Ferroptosis Is Involved In the Development Of Akimentioning

confidence: 99%

Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials

Feng

Qiao

et al. 2022

Front. Pharmacol.

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Acute kidney injury (AKI), a common and serious clinical kidney syndrome with high incidence and mortality, is caused by multiple pathogenic factors, such as ischemia, nephrotoxic drugs, oxidative stress, inflammation, and urinary tract obstruction. Cell death, which is divided into several types, is critical for normal growth and development and maintaining dynamic balance. Ferroptosis, an iron-dependent nonapoptotic type of cell death, is characterized by iron overload, reactive oxygen species accumulation, and lipid peroxidation. Recently, growing evidence demonstrated the important role of ferroptosis in the development of various kidney diseases, including renal clear cell carcinoma, diabetic nephropathy, and AKI. However, the exact mechanism of ferroptosis participating in the initiation and progression of AKI has not been fully revealed. Herein, we aim to systematically discuss the definition of ferroptosis, the associated mechanisms and key regulators, and pharmacological progress and summarize the most recent discoveries about the role and mechanism of ferroptosis in AKI development. We further conclude its potential therapeutic strategies in AKI.

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Section: Ferroptosis Is Involved In the Development Of Akimentioning

confidence: 99%

Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials

Feng

Qiao

et al. 2022

Front. Pharmacol.

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“…RM-induced renal failure accounts for 15% of AKI, and myoglobin (Mb) accumulation in the kidney is the core mechanism 94 . Recent findings showed that renal tubular epithelial cell ferroptosis caused by excessive iron produced by Mb metabolism may be a major mechanism in rhabdomyolysis-induced renal injury 95 . Free Fe 2+ released from Mb degradation catalyzes the production of lipid peroxides through the Fenton reaction, which eventually induces ferroptosis and AKI.…”

Section: The Key Role Of Ferroptosis In Kidney Diseasesmentioning

confidence: 99%

Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases

Feng¹,

Yang²,

Ren³

et al. 2023

Int. J. Biol. Sci.

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Ferroptosis is an iron-dependent programmed cell death pattern that is characterized by iron overload, reactive oxygen species (ROS) accumulation and lipid peroxidation. Growing viewpoints support that the imbalance of iron homeostasis and the disturbance of lipid metabolism contribute to tissue or organ injury in various kidney diseases by triggering ferroptosis. At present, the key regulators and complicated network mechanisms associated with ferroptosis have been deeply studied; however, its role in the initiation and progression of kidney diseases has not been fully revealed. Herein, we aim to discuss the features, key regulators and complicated network mechanisms associated with ferroptosis, explore the emerging roles of organelles in ferroptosis, gather its pharmacological progress, and systematically summarize the most recent discoveries about the crosstalk between ferroptosis and kidney diseases, including renal cell carcinoma (RCC), acute kidney injury (AKI), diabetic kidney disease (DKD), autosomal dominant polycystic kidney disease (ADPKD), renal fibrosis, lupus nephritis (LN) and IgA nephropathy. We further conclude the potential therapeutic strategies by targeting ferroptosis for the prevention and treatment of kidney diseases and hope that this work will provide insight for the further study of ferroptosis in the pathogenesis of kidney-related diseases.

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“…Ишемия кишечника приводит к транслокации микрофлоры в системный кровоток с развитием эндотоксинемии, цитокинемии с последующим развитием сепсиса и септического шока. Данные состояния усугубляют гипоперфузию почек и способствуют прогрессированию ОПП [49,50].…”

Section: патогенез острого повреждения почек при рабдомиолизеunclassified

Current View on the Use of Extracorporeal Detoxification Methods for the Treatment of Rhabdomyolysis (Review)

Masolitin

Проценко

Tyurin

et al. 2023

Obŝaâ reanimatologiâ

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Rhabdomyolysis is a syndrome caused by destruction and necrosis of muscle tissue, which is accompanied by the release of intracellular contents into the systemic circulation. The etiology of rhabdomyolysis is multifaceted, however, regardless of the etiological factor, the central element of its pathophysiology is systemic endotoxemia with multiple organ failure syndrome. Acute renal failure is one of the most common manifestations of organ dysfunction. Considering the pathogenetic model of the development of systemic endotoxemia, the timely use of extracorporeal therapy, which reduces mortality in organ failure, seems promising. All the current types of extracorporeal therapy can be divided into convection (hemoﬁltration), diﬀusion (hemodialysis), convection/diﬀusion (hemodiaﬁltration), sorption (hemoperfusion) and plasma exchange (plasmapheresis, plasma exchange, plasma sorption, etc.) methods based on physical principle.The aim of the review was to summarize the available clinical data on extracorporeal treatments for rhabdomyolysis and to assess the feasibility and best indications for these methods based on the current pathogenetic model of rhabdomyolysis.Material and methods. The search for information was carried out in the Web of Science, Scopus, Medline, PubMed, RSCI, E-library and other databases. Eighty-one sources were identiﬁed containing current therapeutic approaches and relevant data of clinical and scientiﬁc research on the subject of this review.Results. In this review, the main etiological, epidemiological and pathogenetic models of acute renal injury in rhabdomyolysis have been discussed. The main methods of extracorporeal therapy have been reviewed and evaluated based on current understanding, and latest clinical data on their eﬀectiveness have been summarized.Conclusion. The choice of the optimal extracorporeal treatment method, the time of initiation and duration of the procedure still remain controversial. The solution to this issue can potentially help to better correct the electrolyte disturbances and could protect against organ dysfunction, which would improve the outcome in patients with rhabdomyolysis.

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Kidney problems in disaster situations

Cited by 16 publications

References 85 publications

Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials

Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials

Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases

Current View on the Use of Extracorporeal Detoxification Methods for the Treatment of Rhabdomyolysis (Review)

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