Kidney Transplantation from Donor with SARS-CoV-2 Positivity in Brazil

Abstract

Due to uncertainties about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the donation of organs from individuals with suspected or confirmed infection of coronavirus disease 2019 (COVID-19) is absolute contraindication. However, this action caused reduction in the number of kidney transplants and increase in mortality in the waitlist. Because of that, the possibility of extrapulmonary organ transplantation from donors with SARS-CoV-2 positive with asymptomatic or mild illness has been questioned. In this context, the present study aimed to report the case of a 40-year-old female recipient in hemodialysis six years ago, whom received a kidney from donor who had real-time polymerase chain reaction (RT-PCR) test detectable for SARS-CoV-2 after two days of the surgery transplantation. During hospitalization, she had no respiratory symptoms, and all RT-PCR tests for SARS-CoV-2 nasopharyngeal secretion performed had undetectable results. Thus, after 39 days of hospitalization and with good clinical and laboratory evolution, the patient was discharged to remain in outpatient follow-up.

33rd Brazilian Society for Virology (SBV) 2022 Annual Meeting

“…Gustavo Peixoto Duarte da Silva (UFRJ, RJ) Autophagy regulation by early SARS-CoV-2 strains is pivotal for its maintenance [18] Romulo Leão Silva Neris (UFRJ/RJ) Immunoproteasome activation regulates viral replication and mediates muscle damage during arthritogenic alphavirus infection [19] Juan Oswaldo Concha Casaverde (USP, SP) * Rab27a is a host factor required for efficient OROV egress in mammalian cells [20] Bruno Braz Bezerra (UFRJ, RJ) * Hydroxpropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced cytokines [21] Rosa Maria Mendes Viana (USP, SP) Study of permissiveness, expression of viral genes, and cellular effects of respiratory syncytial virus in CD4+ T lymphocytes [22] Human Virology 2…”