KIF18B promotes tumor progression in osteosarcoma by activating β-catenin

Gao, Tian; Yu, Ling; Fang, Zhiwei; Liu, Jiayong; Bai, Chujie; Li, Shu; Xue, Ruifeng; Zhang, Lu; Tan, Zhichao; Fan, Zhengfu

doi:10.20892/j.issn.2095-3941.2019.0452

Cited by 20 publications

(22 citation statements)

References 36 publications

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“…KIFs play important roles in various biological processes, such as mitosis, meiosis, membrane transport, mRNA and protein transport, signal transduction, and microtubule transport [ 3 , 27 , 28 ]. KIF2A and KIF18B have been reported to act as oncogenes that promote OS cell growth and metastasis both in vitro and in vivo [ 6 , 7 ]. These are particularly interesting findings, and at least these genes can act as poor prognostic markers.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that abnormal expression of kinesin superfamily proteins (KIFs) is related to the development and progression of various human cancers [ 4 , 5 ]. Among these, KIF2A,KIF18B, KIF26B expression correlates with tumorigenicity and poor OS prognosis [5] , [6] , [7] . KIF4A expression has been found to be significantly up-regulated in multiple tumor tissues, and high expression of KIF4A in cancers is reported to promote tumor progression and metastasis [8] , [9] , [10] , [11] .…”

Section: Introductionmentioning

confidence: 99%

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Chondrocyte-derived Exosomal miR-195 Inhibits Osteosarcoma Cell Proliferation and Anti-Apoptotic by Targeting KIF4A in vitro and in vivo

Lu¹,

Cao²,

Lan³

et al. 2022

Translational Oncology

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Highlights Osteosarcoma (OS) chemoresistance and distant metastasis are directly associated with OS recurrence and dismal patient prognosis, which are serious concerns for the medical community. However, current knowledge on OS pathogenesis and treatment remains limited. We found that kinesin superfamily protein 4A (KIF4A) acts as a potential OS biomarker. KIF4A promoted OS cell proliferation and anti-apoptotic in vitro and enhanced tumor growth in vivo. Our results indicate that miR-195 inhibits the expression of KIF4A by directly targeting its 3’-untranslated region Hence, targeting KIF4A could be a novel therapeutic strategy for OS and miR-195 may be a potential KIF4A-targeting drug. Furthermore, this study demonstrates that normal human chondrocytes can be used to produce miR-195-carrying exosomes to successfully deliver miR-195 into OS cells. Thus, our results suggest that chondrocyte-derived exosomal miR-195 may be developed into a potential adjuvant chemotherapeutic drug.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chondrocyte-derived Exosomal miR-195 Inhibits Osteosarcoma Cell Proliferation and Anti-Apoptotic by Targeting KIF4A in vitro and in vivo

Lu¹,

Cao²,

Lan³

et al. 2022

Translational Oncology

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“…KIF18B, a member of kinesin superfamily, has a long-reported significant effect on the onset and progression of cancer. 23 , 24 Wang et al 25 have identified KIF18B as a risk gene in the metastasis of ccRCC. HJURP, a histone H3 chaperone, was identified as a crucial factor in DNA binding and phosphorylation, which promotes chromosome segregation and cell mitosis.…”

Section: Discussionmentioning

confidence: 99%

IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma

Meng

Liang

et al. 2021

IJGM

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The study was designed to mine the expression and roles of IQGAP3 in clear cell renal cell carcinoma (ccRCC). Methods: Expression profiles and clinical information were obtained from the Cancer Genome Atlas (TCGA) to estimate IQGAP3 expression in ccRCC, its relationship with patients' clinicopathological variables and prognosis, and the potential biological mechanisms. Results: IQGAP3 was highly expressed in ccRCC and indicated advanced clinical outcome and poor prognosis. IQGAP3 affected the progression of ccRCC through several cancerrelated pathways. IQGAP3 might play a vital role in the ccRCC tumor microenvironment. Conclusion: IQGAP3 could serve as a promising prognostic biomarker and therapeutic target.

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“…Based on the important roles of KIFs in various cancers, we have summarized the functional roles of KIFs in osteosarcoma in Table 2 (Ref. [16,17,59,61,106]) and the following sections.…”

Section: Kifs In Osteosarcomamentioning

confidence: 99%

“…For example, Wang et al [15] showed that KIF2A is highly expressed in osteosarcoma, and inhibiting the expression of KIF2A can effectively prevent the spread and migration of tumors and the invasion of osteosarcoma cells in vitro, as well as block tumor growth and metastasis in mice [16]. Gu et al [17] showed that KIF18B is highly expressed in osteosarcoma tissues and cells and that inhibiting the expression of KIF18B significantly inhibits the proliferation, migration, and invasion of osteosarcoma cells, as well as the tumor formation ability. Other studies have shown that KIFs can be used as biomarkers for the diagnosis and treatment of osteosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Kinesin superfamily proteins: roles in osteosarcoma

Song

Xue³

et al. 2021

Front. Biosci. (Landmark Ed)

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Background: Osteosarcoma is a common bone tumor with extremely high malignancy, occurring mostly in children and adolescents. At present, the survival rate of osteosarcomas has made progress in some aspects; however, this can only be regarded as a partial success because substantial progress has not been made in the last few decades. Object: The kinesin superfamily is a group of proteins that play regulatory roles in various metabolic processes and are closely related to tumor metastasis. Increasing evidence shows that kinesins play key roles in the occurrence and development of human cancer. Purpose: This review summarizes the roles of the kinesin superfamily proteins in osteosarcoma and related functions.Abbreviations: ATPase, adenosine triphosphatase; KIFs, kinesin superfamily protein.

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KIF18B promotes tumor progression in osteosarcoma by activating β-catenin

Cited by 20 publications

References 36 publications

Chondrocyte-derived Exosomal miR-195 Inhibits Osteosarcoma Cell Proliferation and Anti-Apoptotic by Targeting KIF4A in vitro and in vivo

Chondrocyte-derived Exosomal miR-195 Inhibits Osteosarcoma Cell Proliferation and Anti-Apoptotic by Targeting KIF4A in vitro and in vivo

IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma

Kinesin superfamily proteins: roles in osteosarcoma

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