Kikuchi-Fujimoto Disease

Kulak, Jessica L.; Smith, Lee P.; Acar, Behram Cenk; Weed, Donald T.

doi:10.1177/014556130908800905

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…Immunohistochemical staining may reveal a predominance of CD8-positive lymphocytes 30. These stains assist in differentiating KFD from lymphoma 3. In large B-cell lymphoma, neoplastic cells are CD20 positive, whereas the large cells in KFD are CD8-positive immunoblasts and CD68-positive histiocytes 3,26, 30…”

Section: Discussionmentioning

confidence: 99%

“…The initial presentation of KFD includes cervical lymphadenopathy, low-grade fever, headache, and fatigue 3,4. Other less common symptoms include nausea, vomiting, night sweats, and weight loss.…”

Section: Introductionmentioning

confidence: 99%

“…Cutaneous manifestations may also be a presenting sign; however, this is a less common finding 4. Laboratory studies may reveal leukopenia, anemia, elevated erythrocyte sedimentation rate, and elevated C-reactive protein 3. Atypical lymphocytes may also be present in the peripheral blood 4…”

Section: Introductionmentioning

confidence: 99%

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Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Deaver

Naghashpour

Sokol

2013

Mediterr J Hematol Infect Dis

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Kikuchi-Fujimoto Disease (KFD), also known as histiocytic lymphadenitis, is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue. There is a higher incidence of KFD in women aged 20–35 years and in Asian populations. A PubMed search revealed 590 articles that described KFD. Of these, 22 cases have been fully described in the United States. Ten of the 22 (45%) patients were male and 12 (55%) were female, with 20% Caucasian, 20% Asian American, and the remaining 60% of other ethnic backgrounds. In this study, we describe an additional 3 cases of KFD and discuss the diagnosis, pathology, and management of KFD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Deaver

Naghashpour

Sokol

2013

Mediterr J Hematol Infect Dis

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“…Lymphdenitis (Painful lymph nodes with swelling); Lymph Node non-tender and rubbery; Mild shortness of breath; Night sweats, fatigue, nausea and vomiting; High Fever (Continuous); Muscles pain, headache and weight loss; Cough [4].…”

Section: Symptomsmentioning

confidence: 99%

A Recent Case Reports on Unfamiliar Kikuchi-Fujimoto Disease

Kaur¹,

Wani²,

Yadav³

et al. 2019

Med Clin Rev

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Kikuchi-Fujimoto Disease (KFD) is also known as Histiocytic Necrotizing Lymphadenitis. It is very rare, noncancerous and self-limiting Auto-Immune disease but mostly suspected as cancer, tuberculosis and systemic lupus erythematosus. It has symptoms such as cervical lymphadenopathy (enlargement of lymph nodes), low fever, headache, fatigue, night sweats and muscles pain. It typically affects young females aged between 20-35 years and mostly affects Asian populations. The main identification of KFD is characterized by Fine Needle Aspiration Cytology by taking blood sample from the swollen lymph node. Diagnosis is also possible with Fine Needle Aspiration Biopsy. Treatment for this disease has not been established. Non-steroidal Anti-Inflammatory Drugs or steroids are in use to ease the tenderness of lymph node and fever.

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“…Kikuchi-Fujimoto Disease usually manifests with fever and lymphadenopathy, with the jugulo-carotid and cervical lymph nodes being the most commonly affected. 8–11 It is important to recognize KFD as a clinical identity, as it may mimic other conditions such as lymphoma, infectious etiologies, and autoimmune diseases, specifically systemic lupus erythematosus (SLE). According to 1 study, 30% of cases of KFD were incorrectly diagnosed as lymphoma.…”

Section: Introduction/backgroundmentioning

confidence: 99%

Kikuchi-Fujimoto Disease in Michigan: A Rare Case Report and Review of the Literature

Singh¹,

Shermetaro²

2019

Clin Med Insights Ear Nose Throat

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Background: Kikuchi-Fujimoto Disease (KFD), also known as Histiocytic Necrotizing Lymphadenitis, is a rare cause of prolonged cervical lymphadenopathy in both the pediatric and adult populations. It was first reported in Japan in 1972, and since, this disease has been described worldwide, although most cases have been reported in Asia. The etiology of KFD is not fully understood, although there are 2 theories that are described in detail in this review. Kikuchi-Fujimoto Disease typically follows a benign course, with resolution of the lymphadenopathy within 6 months. It is important to recognize KFD as a cause of persistent lymphadenopathy, as it shares many characteristics with and must be differentiated from other causes of lymphadenopathy, including lymphoma, inflammatory disorders, autoimmune conditions, and infectious causes of lymphadenopathy. Case presentation: Here is presented a case of an 11-year-old male who was born in Vietnam, but subsequently adopted and raised in the United States, who presented to a private practice community-based Otolaryngology group. His chief complaint was a persistent neck mass of approximately 3 months duration. He underwent excisional biopsy for suspected lymphoma, but final pathology rendered a diagnosis of KFD. Conclusion: The purpose of this article is not only to review the literature but also to contribute awareness of this entity in the differential diagnosis of persistent lymphadenopathy, especially for the general Otolaryngologist in a community-based setting. In addition, this review would be beneficial for other practitioners as well, specifically Pediatricians, Infectious Disease Physicians, Rheumatologists, Pathologists, and Medical Oncologists.

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Kikuchi-Fujimoto Disease

Abstract: Histiocytic necrotizing lymphadenitis-also known as Kikuchi -Fujimoto disease (KFD)-is a rare disease of unknown etiology. It was first described independently by Kikuchi ' and by Fujimoto et al' in articles published

Cited by 6 publications

References 7 publications

Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

A Recent Case Reports on Unfamiliar Kikuchi-Fujimoto Disease

Kikuchi-Fujimoto Disease in Michigan: A Rare Case Report and Review of the Literature

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