Killer cell immunoglobulin like receptor gene association with tuberculosis

Pydi, Satya Sudheer; Sunder, Sharada Ramaseri; Venkatasubramanian, Sambasivan; Kovvali, Srinivas; Jonnalagada, Subbanna; Valluri, Vijaya Lakshmi

doi:10.1016/j.humimm.2012.10.006

Cited by 23 publications

(21 citation statements)

References 47 publications

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“…The genotypes with IDs 1, 2, 3, 4, 5, 6, 7 and 73 which were commonly reported in Indian populations were observed at higher frequencies confirming the earlier findings. Though the number of unique genotypes reported in the present study is low compared to studies from related Indian populations (Guha et al ., ; Pydi et al ., ), these unique genotypes add upto the genetic diversity of KIR genotypes observed in Indian populations and could be a result of racial admixture and local specific selection pressures. As observed in other studies from India, the AB and BB group genotypes were more frequent (Rajalingam et al ., , ; Kulkarni et al ., ).…”

Section: Discussionmentioning

confidence: 99%

“…Certain KIRs are involved in inhibiting the cytotoxic function (KIR3DL1-KIR3DL3, KIR2DL1-KIR2DL3 and KIR2DL5), while some cause activation (KIR3DS1, KIR2DS1-KIR2DS5), and KIR2DL4 has both the functions. Inhibitory receptors regulate the activity of NK cells by recognizing HLA class I ligands present in the target cells, while the ligands for most of the activating receptors are unknown (Rajagopalan & Long, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Profile of killer cell immunoglobulin‐like receptor and its human leucocyte antigen ligands in dengue‐infected patients from Western India

Alagarasu

Bachal

Shah

et al. 2015

Int J Immunogenetics

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Killer cell immunoglobulin-like receptors (KIRs) regulate the activation of natural killer cells (NKs). Qualitative and quantitative differences in the type and the number of KIRs expressed on NK cells affect its activation which would influence the outcome of the disease. In this study, 114 hospitalized cases of dengue [82 dengue fever (DF) and 32 dengue haemorrhagic fever (DHF) cases] and 104 healthy controls (HC) without no known history of hospitalization for dengue-like illness were investigated for their KIR gene profile to find out the association of KIR genes with dengue disease severity. KIR gene profile was investigated using duplex sequence-specific priming polymerase chain reaction-based typing system. The results revealed a higher frequency of KIR3DL1 gene [P = 0.0225; odds ratio (OR) 4.1 95% confidence interval (CI) 1.1-14.8] and lower frequency of KIR3DS1/3DS1 genotype [P = 0.0225; OR 0.24 95% CI (0.068-0.88)] in DF cases compared to HC. Immunoglobulin-like receptor gene frequencies were not different between DHF and DF or HC. The results suggest that KIR3DL1/KIR3DS1 locus might be associated with the risk of developing DF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Profile of killer cell immunoglobulin‐like receptor and its human leucocyte antigen ligands in dengue‐infected patients from Western India

Alagarasu

Bachal

Shah

et al. 2015

Int J Immunogenetics

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“…Previous studies have shown the involvement of KIR genes and their ligands in infectious diseases, such as AIDS, malaria, hepatitis C, tuberculosis and leprosy , autoimmune diseases, such as psoriasis, pemphigus foliaceus and ankylosing spondylitis , and also in many types of cancer, including leukaemia, lymphoma and bladder, colorectal and laryngeal tumours . KIR receptors exert their influence on susceptibility to or protection from certain diseases by means of a balance between the signals of activation or inhibition that regulate the function of NK cells.…”

Section: Discussionmentioning

confidence: 99%

Influence of KIR genes and their HLA ligands in susceptibility to dengue in a population from southern Brazil

et al. 2013

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Killer cell immunoglobulin-like receptors (KIR) form a group of regulatory molecules that specifically recognise human leukocyte antigen (HLA) class I molecules, modulating the cytolytic activity of natural killer cells. The purpose of this study was to investigate the influence of KIR genes and their class I HLA ligands in susceptibility to dengue fever in a population from southern Brazil through a case-control study. One hundred four subjects with confirmed diagnoses of dengue participated in this study, along with a control group of 172 individuals from the same geographic area. HLA and KIR genotyping was performed by polymerase chain reaction with sequence-specific oligonucleotide probes (PCR-SSOP) and with sequence-specific primer (PCR-SSP) techniques, respectively. Data analysis showed significant differences for the KIR2DS1 (54.8% vs 40.7%, P = 0.03), KIR2DS5 (50.0% vs 36.0%, P = 0.03) and KIR2DL5 (76.0% vs 56.4%, P = 0.001) genes. With regard to KIR-ligand pairs, positive associations with dengue were observed in KIR3DS1-Bw4 (45.2% vs 29.7%, P = 0.01), KIR3DL1-Bw4 (80.7% vs 65.1%, P < 0.001), KIR2DL1-C2 (75.0% vs 62.2%, P = 0.03) and KIR2DS1-C2 (40.4% vs 25.6%, P = 0.01) interactions, and a negative association in KIR2DL3-C1/C1 (18.2% vs 33.1%, P = 0.01). Furthermore, the analysis of KIR haplogroups showed a possible protective factor against dengue fever in individuals with the AA genotype. Taken together, these results suggest the existence of genetic predisposition to dengue fever in the population from southern Brazil.

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“…A growing number of studies have identified associations between the presence of the activating KIR2DS1 receptor and susceptibility to autoimmune diseases 6–8 , reproductive success 9, 10 , control of viral infections 11, 12 and malignancy in cancer 13–15 . However, the precise ligands for KIR2DS1, and their consequences for KIR2DS1+ NK-cell function, are not well characterized.…”

Section: Introductionmentioning

confidence: 99%

Peptide-specific engagement of the activating NK cell receptor KIR2DS1

Chapel

García-Beltrán

Hölzemer

et al. 2017

Sci Rep

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The activating NK cell receptor KIR2DS1 has been shown to be involved in many disorders including autoimmune diseases, malignancies and pregnancy outcomes. However, the precise ligands and functions of this receptor remain unclear. We aimed to gain a better understanding of the factors involved in the binding of KIR2DS1 and its inhibitory counterpart KIR2DL1 to HLA class I molecules, and the consequences for KIR2DS1+ NK-cell function. A systematic screen that assessed binding to 97 HLA-I proteins confirmed that KIR2DS1-binding was narrowly restricted to HLA-C group 2 complexes, while KIR2DL1 showed a broader binding specificity. Using KIR2DS1ζ+ Jurkat reporter-cells and peptide-pulsed 721.221.TAP1KO-HLA-C*06:02 cells, we identified the synthetic peptide SRGPVHHLL presented by HLA-C*06:02 that strongly engaged KIR2DS1- and KIR2DL1-binding. Functional analysis showed that this HLA-C*06:02-presented peptide can furthermore activate primary KIR2DS1(+) NK cell clones. Thus, we demonstrated peptide-dependent binding of the activating NK cell receptor KIR2DS1, providing new insights into the underlying mechanisms involved in KIR2DS1-related disorders.

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Killer cell immunoglobulin like receptor gene association with tuberculosis

Cited by 23 publications

References 47 publications

Profile of killer cell immunoglobulin‐like receptor and its human leucocyte antigen ligands in dengue‐infected patients from Western India

Profile of killer cell immunoglobulin‐like receptor and its human leucocyte antigen ligands in dengue‐infected patients from Western India

Influence of KIR genes and their HLA ligands in susceptibility to dengue in a population from southern Brazil

Peptide-specific engagement of the activating NK cell receptor KIR2DS1

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