Kimura Disease: A Case Report and Review of Literature

Nagaraj, Sushmitha; Singh, Suresh; Sharma, Vineet; Soni, Ankita; Harshvardhan, Rekha; Agarwal, Sunita

doi:10.1007/s12070-020-01870-5

Cited by 5 publications

(6 citation statements)

References 12 publications

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“…Intralesional injection of corticosteroids has afforded good results. The disease recurrence rate attains 40% [17]. KD is benign and self-limited; malignant transformation has not been recorded.…”

Section: Discussionmentioning

confidence: 99%

Kimura Disease: A Rare Case in Vietnamese Woman

Le,

Tran,

Pham

2023

Preprint

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Background: Kimura disease (KD) is a rare benign chronic inflammatory condition that predominantly affects Asian males. It is characterized by subcutaneous tissue masses in the head and neck region, enlarged lymph nodes, increased blood eosinophilia, and elevated serum total IgE levels. In this report, we describe a rare case of KD in a young Vietnamese female. Case summary: A 31-year-old Vietnamese woman presented to the hospital with 2 masses in the bilateral cheeks and 1 mass behind the left ear that persisted for 15 years, recurrent skin itching, elevated serum total IgE levels and increased blood eosinophilia. No medical history of the individual or family was recorded. We performed an excision biopsy of the postauricular mass which revealed follicular hyperplasia with small vessel hyperplasia, diffuse infiltration of eosinophils in lymphoid follicles, and several eosinophilic microabscesses. After a comprehensive review, the final diagnosis for this patient was KD and atopic dermatitis comorbidity. Conclusion: KD is not limited to males, as this report demonstrated. The histopathological examination plays an important role in the diagnosis of KD. This case illustrated the characteristic description of KD and highlights the need for awareness of this rare disease in Asian women.

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Section: Discussionmentioning

confidence: 99%

Kimura Disease: A Rare Case in Vietnamese Woman

Le,

Tran,

Pham

2023

Preprint

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“…KD, though rare, is encountered in South East Asian countries such as Japan, China and the Philippines. Only isolated case reports have been documented from various parts of India 9,10 with three cases from a tertiary referral institute. 11…”

Section: Discussionmentioning

confidence: 99%

A common presentation of an uncommon pathology: Kimura disease

et al. 2023

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Kimura's disease is a chronic, benign inflammatory condition of the subcutaneous tissue. It presents as painless, subcutaneous nodules of the head and neck, which are firm, painless, and may be single or multiple. It is most commonly seen in young adult Asian men. The nodes remain stable or may slowly enlarge over time. Elevated serum immunoglobulin E (IgE) levels, peripheral blood eosinophilia and lymphoid proliferation with eosinophilic infiltration on histopathological examination are the characteristic features. Spontaneous regression is usually seen. The diagnosis of Kimura's disease can be difficult and misleading, and it is important not to ignore histopathological features.

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“…Corticosteroid therapy has been used particularly in patients with multiple organ involvement, but relapses often occur when the dose is reduced or stopped [16]. Corticosteroid therapy alone has not shown convincing results due to its transient effects [17]. Intralesional injections of corticosteroids have also shown good results [17].…”

Section: Discussionmentioning

confidence: 99%

“…Corticosteroid therapy alone has not shown convincing results due to its transient effects [17]. Intralesional injections of corticosteroids have also shown good results [17]. Nakahara et al reported that steroid therapy can control lesions, lymphadenopathy, and nephrotic syndrome, but local recurrence was common during the period of steroid tapering [18].…”

Section: Discussionmentioning

confidence: 99%

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Kimura's Disease: A Literature Review Based on a Clinical Case

Brito,

Baptista,

Pereira

et al. 2023

Cureus

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Kimura's disease (KD) was first described in 1937. It is a rare, benign, and chronic immune-mediated inflammatory disorder affecting the subcutaneous tissue, salivary glands, and lymph nodes. The disease is more common in the second to third decades of life in middle-aged Southeast Asian countries. The cause of Kimura's disease remains unknown; some authors believe it is related to an autoimmune or delayed-type hypersensitivity reaction. It commonly presents as a solitary painless lymph node in the head and neck or generalized lymphadenopathy (67%-100%) associated with peripheral eosinophilia and elevated IgE levels. Renal involvement may occur in some patients. Diagnosis is made by histology.A 21-year-old Caucasian man with no relevant medical history presented with a non-tender swelling of the left hemiface without other associated symptoms. Laboratory investigations revealed a leukocyte count with eosinophilia (2.29×10^9/L-26.5%) and elevated total IgE and IgG4. He had no renal dysfunction. He underwent surgical resection of the lesion in the jugal, infraorbital, and left nasolabial regions, and the anatomopathological examination revealed the characteristics of Kimura's disease. Three months after surgery, an MRI showed an increase in the size of the mass, and he was started on corticosteroids. Six months after surgery, he presented with a slight increase in the size of the mass and was started on Ciclosporin, which allowed a progressive reduction in the dose of corticosteroid with evidence of a progressive reduction in swelling. Ciclosporin was stopped due to toxic serum levels, and he was started on mycophenolate mofetil. The dose was increased because of the increase in facial mass; on mycophenolate mofetil 2500mg/day, the patient remains stable.KD is a chronic disorder of unknown etiology that mainly affects young people in Southeast Asia and is rare in Western countries, as in the case of this young man. Studies have shown no significant differences in region or race, complications, multiplicity, laterality, anatomical distribution, maximum size, eosinophil count, or IgE levels between age groups. There is no consensus on the optimal treatment for KD; several treatments have been used, including surgery, systemic corticosteroids, immunosuppressants, and radiation. Due to the tendency to relapse and the rarity of the disease, there is no consensus on treatment options for relapse.

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Kimura Disease: A Case Report and Review of Literature

Cited by 5 publications

References 12 publications

Kimura Disease: A Rare Case in Vietnamese Woman

Kimura Disease: A Rare Case in Vietnamese Woman

A common presentation of an uncommon pathology: Kimura disease

Kimura's Disease: A Literature Review Based on a Clinical Case

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