Kindlin-2 controls angiogenesis through modulating Notch1 signaling

Dong, Yuxuan; Ma, Guixing; Hou, Xiaoting; Han, Yingying; Ding, Zhen; Tang, Wanze; Chen, Litong; Chen, Yangshan; Zhou, Bo; Rao, Feng; Lv, Kaosheng; Du, Changzheng; Cao, Huiling

doi:10.1007/s00018-023-04866-w

Cited by 3 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunohistochemical (IHC) staining of α-SMA and CD31 (biomarker of angiogenesis) was performed to assess the level of a newly formed blood vessel. 36 Consistently, the highest expressions of α-SMA (Figure 6e,f) and CD31 (Figure S19) arose from the VEGF@Gel EFM treatment group, while Gel EFM itself induces a moderate increase in α-SMA and CD31 expression. The in vivo ROS-scavenging efficacy of the hydrogels was also assessed using IHC staining for the proinflammatory cytokines IL-6 and IL-1β.…”

Section: Diabetic Wound Healing In Vivosupporting

confidence: 55%

“…In addition, the VEGF@Gel EFM -treated group also exhibited the highest degree in collagen deposition (45.58%, P < 0.001), as revealed by Masson staining (Figure c,d). Immunohistochemical (IHC) staining of α-SMA and CD31 (biomarker of angiogenesis) was performed to assess the level of a newly formed blood vessel . Consistently, the highest expressions of α-SMA (Figure e,f) and CD31 (Figure S19) arose from the VEGF@Gel EFM treatment group, while Gel EFM itself induces a moderate increase in α-SMA and CD31 expression.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Facile Reactive Oxygen Species-Scavenging Supramolecular Hydrogel to Promote Diabetic Wound Healing

Jia,

Li,

Jiang

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Chronic wound healing impairment is a significant complication in diabetes. Hydrogels that maintain wound moisture and enable sustained drug release have become prominent for enhancing chronic wound care. Particularly, hydrogels that respond to reactive oxygen species (ROS) are sought-after for their dual capacity to mitigate ROS and facilitate controlled drug delivery at the wound site. We have strategically designed an ROS-responsive and scavenging supramolecular hydrogel composed of the simple hexapeptide Glu-Phe-Met-Phe-Met-Glu (EFM). This hydrogelator, composed solely of canonical amino acids without additional ROS-sensitive motifs, forms a hydrogel rapidly upon sonication. Interaction with ROS leads to the oxidation of Met residues to methionine sulfoxide, triggering hydrogel disassembly and consequent payload release. Cellular assays have verified their biocompatibility and efficacy in promoting cell proliferation and migration. In vivo investigations underscore the potential of this straightforward hydrogel as an ROS-scavenger and drug delivery vehicle, enhancing wound healing in diabetic mice. The simplicity and effectiveness of this hydrogel suggest its broader biomedical applications in the future.

show abstract

Section: Diabetic Wound Healing In Vivosupporting

confidence: 55%

Section: Resultsmentioning

confidence: 99%

Facile Reactive Oxygen Species-Scavenging Supramolecular Hydrogel to Promote Diabetic Wound Healing

Jia,

Li,

Jiang

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

The activation of the HIF-1α-VEGFA-Notch1 signaling pathway by Hydroxysafflor yellow A promotes angiogenesis and reduces myocardial ischemia–reperfusion injury

Ge,

Meng,

Peng

et al. 2024

International Immunopharmacology

View full text Add to dashboard Cite

Pan-cancer analyses suggest kindlin-associated global mechanochemical alterations

Chowdhury,

Mistry,

Maity

et al. 2024

Commun Biol

View full text Add to dashboard Cite

Kindlins serve as mechanosensitive adapters, transducing extracellular mechanical cues to intracellular biochemical signals and thus, their perturbations potentially lead to cancer progressions. Despite the kindlin involvement in tumor development, understanding their genetic and mechanochemical characteristics across different cancers remains elusive. Here, we thoroughly examined genetic alterations in kindlins across more than 10,000 patients with 33 cancer types. Our findings reveal cancer-specific alterations, particularly prevalent in advanced tumor stage and during metastatic onset. We observed a significant co-alteration between kindlins and mechanochemical proteome in various tumors through the activation of cancer-related pathways and adverse survival outcomes. Leveraging normal mode analysis, we predicted structural consequences of cancer-specific kindlin mutations, highlighting potential impacts on stability and downstream signaling pathways. Our study unraveled alterations in epithelial–mesenchymal transition markers associated with kindlin activity. This comprehensive analysis provides a resource for guiding future mechanistic investigations and therapeutic strategies targeting the roles of kindlins in cancer treatment.

show abstract

Kindlin-2 controls angiogenesis through modulating Notch1 signaling

Cited by 3 publications

References 61 publications

Facile Reactive Oxygen Species-Scavenging Supramolecular Hydrogel to Promote Diabetic Wound Healing

Facile Reactive Oxygen Species-Scavenging Supramolecular Hydrogel to Promote Diabetic Wound Healing

The activation of the HIF-1α-VEGFA-Notch1 signaling pathway by Hydroxysafflor yellow A promotes angiogenesis and reduces myocardial ischemia–reperfusion injury

Pan-cancer analyses suggest kindlin-associated global mechanochemical alterations

Contact Info

Product

Resources

About