Kinetic, product, and computational studies of the ultrasonic induced degradation of 4-methylcyclohexanemethanol (MCHM)

Cui, Danni; Mebel, Alexander M.; Arroyo, Luis; Holness, H.; Furton, Kenneth G.; Ο'Shea, Kevin Ε.

doi:10.1016/j.watres.2017.09.005

Cited by 21 publications

(9 citation statements)

References 42 publications

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“…MCHM is not easily degraded biologically because of its low reactivity [6]. In contrast to other well-studied hydrocarbons, such as cyclohexane and benzene, the effects of MCHM on metabolism are under studied [7].…”

Section: Introductionmentioning

confidence: 99%

MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast

Pupo

Ayers

Sherman

et al. 2019

Biol Trace Elem Res

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While drugs and other industrial chemicals are routinely studied to assess risks, many widely used chemicals have not been thoroughly evaluated. One such chemical, 4-methylcyclohexane methanol (MCHM), is an industrial coal-cleaning chemical that contaminated the drinking water supply in Charleston, WV, USA in 2014. While a wide range of ailments was reported following the spill, little is known about the molecular effects of MCHM exposure. We used the yeast model to explore the impacts of MCHM on cellular function. Exposure to MCHM dramatically altered the yeast transcriptome and the balance of metals in yeast. Underlying genetic variation in the response to MCHM, transcriptomics and, mutant analysis uncovered the role of the metal transporters, Arn2 and Yke4, to MCHM response. Expression of Arn2, which is involved in iron uptake, was lower in MCHMtolerant yeast and loss of Arn2 further increased MCHM tolerance. Genetic variation within Yke4, an ER zinc transporter, also mediated response to MCHM, and loss of Yke4 decreased MCHM tolerance. The addition of zinc to MCHM-sensitive yeast rescued growth inhibition. In vitro assays demonstrated that MCHM acted as a hydrotrope and prevented protein interactions, while zinc induced the aggregation of proteins. We hypothesized that MCHM altered the structures of extracellular domains of proteins, and the addition of zinc stabilized the structure to maintain metal homeostasis in yeast exposed to MCHM.

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Section: Introductionmentioning

confidence: 99%

MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast

Pupo

Ayers

Sherman

et al. 2019

Biol Trace Elem Res

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“…In addition, the calculated E a of US/Fe 0 f -O SC was 33.227 kJ·mol −1 > 10–13 kJ·mol −1 , indicating that degradation process was dominated by an intrinsic chemical reaction rather than a diffusion process. According to study of Cui et al [32] , the modified Freundlich Isotherm (Eq. (22) ) could be applied to describe the relationship between the amounts of molecules partitioning (adsorption) at the interface of cavitation bubble and the initial concentration at equilibrium in US-based systems.…”

Section: Resultsmentioning

confidence: 99%

Ultrasonic role to activate persulfate/chlorite with foamed zero-valent-iron: Sonochemical applications and induced mechanisms

Zhang

Leng

et al. 2021

Ultrasonics Sonochemistry

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Highlights The novel foamed-ZVI activating persulfate/chlorite by ultrasonic was applied. The real-time and online continuous detections tracked radicals transformation. The EPR spectra with different systems in different mixtures were detected. The free or non-free radicals processes induced by US were explored. The dynamics on cavitation and the US-field simulation were presented.

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“…The growth and collapse of bubbles are related to the transfer of energy at high pressures and temperatures due to the highly reactive free radicals such as hydrogen radicals (H•) and hydroxyl radicals (OH•). Bubbles generate three zones, such as a hot spot (5000°C, 500 atm), a gas-liquid interface (300°C, 50 atm), and a bulk solution (25°C, 1 atm) [11].…”

Section: Introductionmentioning

confidence: 99%

The Viscosity Behaviour of PEGylated Locust Bean Gum/Rosin Ester Polymeric Nanoparticles

Karakuş¹,

İlgar²,

Tan³

et al. 2020

Colloid Science in Pharmaceutical Nanotechnology

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In this study, PEGylated locust bean gum-rosin glycerol ester polymeric nanoparticles (PEG-LBG/RE PNPs) were synthesized by using simple ultrasonic irradiation method. The nanoparticles were characterized by using Fouriertransform infrared spectroscopy (FTIR) and scanning transmission electron microscopy (STEM). The viscosity behaviors of nanoparticles were studied in different conditions (pH, sonication time, and salt). The experimental results were calculated by Huggins, Kraemer, Tanglertpaibul-Rao, and Higiro models to understand the colloidal stability, the miscibility mechanism, and coefficients of nanoparticles. The results confirmed that the homogenous distribution of nanostructure was related to sonication time (30 min) and the presence of NaOH salt. With the addition of NaOH, the nanosystem based on ionotropic gelation technique was made more homogeneous. The results made us think that nanoparticles can be a good candidate for drug delivery systems in biomedical and pharmaceutical applications.

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Kinetic, product, and computational studies of the ultrasonic induced degradation of 4-methylcyclohexanemethanol (MCHM)

Cited by 21 publications

References 42 publications

MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast

MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast

Ultrasonic role to activate persulfate/chlorite with foamed zero-valent-iron: Sonochemical applications and induced mechanisms

The Viscosity Behaviour of PEGylated Locust Bean Gum/Rosin Ester Polymeric Nanoparticles

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