Kinetic studies of nitrofurazone photodegradation by multivariate curve resolution applied to UV-spectral data

Luca, Michele De; Mas, Sergi; Ioele, Giuseppina; Oliverio, Filomena; Ragno, Gaetano; Tauler, Romà

doi:10.1016/j.ijpharm.2009.11.003

Cited by 42 publications

(26 citation statements)

References 35 publications

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“…Multivariate curve resolution-alternating least squares [8,9] does not need a chemical model to be previously postulated. 1.01 × 10 À5 1.01 × 10 À5 2.03 × 10 À5 D 3 1.01 × 10 À5 2.03 × 10 À5 1.01 × 10 À5 D 4 1.01 × 10 À5 3.04 × 10 À5 1.01 × 10 À5 The so-called hard model free analysis methods such as MCR-ALS can be applied to the spectrophotometric kinetic evolutionary data to give preliminary insight into the time position of the components relative to each other.…”

Section: Multivariate Curve Resolution-alternating Least Squares and mentioning

confidence: 99%

Chemometrics study of the kinetics of the Griess reaction

Shariati-Rad

Irandoust

Haghighi

2013

Journal of Chemometrics

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The kinetics of the Griess reaction in which 3‐nitroaniline acts as a nitrosation agent and 1‐naphtylamine as a coupling reagent was studied by chemometrics methods. The kinetic reaction was investigated under pH 1.0 and 25°C by UV‐vis spectrophotometry. The concentrations of nitrite, 3‐nitroaniline and 1‐naphtylamine were such that a second‐order kinetic reaction took place. Data explorations based on principal component analysis and multivariate curve resolution–alternating least squares were performed to obtain information about the reaction. Calculation of band boundaries of the multivariate curve resolution–alternating least squares solutions showed that the rotational ambiguities associated with the calculation of spectra and concentration profiles have been completely removed. The decrease in the ambiguity of the recovered solutions was closely related to the application of the equality constraint. The results of the exploratory data analysis showed that the kinetic reaction proceeds through a two‐step mechanism. Moreover, the two‐steps are second order. Data analysis approaches based on hard modeling and global hard modeling were used to resolve profiles of the reactants, intermediates and products and to evaluate the rate constants. Copyright © 2013 John Wiley & Sons, Ltd.

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Section: Multivariate Curve Resolution-alternating Least Squares and mentioning

confidence: 99%

Chemometrics study of the kinetics of the Griess reaction

Shariati-Rad

Irandoust

Haghighi

2013

Journal of Chemometrics

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“…According to our previous work (14), the residual concentration of the target compounds was determined by applying the MCR algorithm to the spectral data. This chemometric procedure was adopted for its ability to determine, during the entire photodegradation process, the number of involved species and their concentration and at the same time to plot their absorbance spectra (20)(21)(22). All tested compounds were confi rmed to be sensitive to light, showing 10 % degradation in less than twenty minutes of irradiation.…”

Section: Photostability Studymentioning

confidence: 99%

“…Due to the well-known photo-lability of DHPs (15)(16)(17)(18), the synthesized compounds were subjected to photodegradation tests (19). Concentration of parent compounds and by-products was calculated by multivariate curve resolution-alternating least squares (MCR-ALS) applied to the spectral data (20)(21)(22).…”

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confidence: 99%

Synthesis and photodegradation studies of analogues of muscle relaxant 1,4-dihydropyridine compounds

et al. 2017

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This paper describes the synthesis of 1,4-dihydropyridine compounds (DHPs) endowed with good muscle relaxant activity and stability to light. Six new condensed DHPs were synthesized by the microwave irradiation method. A long-chain ester moiety [2-(methacryloyloxy)ethyl] and various substituents on the phenyl ring were demonstrated to aff ect the muscle relaxant activity occurring in isolated rabbit gastric fundus smooth muscle strips. Forced photodegradation conditions were applied to the molecules according to the ICH rules. The degradation profi le of the drugs was monitored by spectrophotometry coupled with the multivariate curve resolution technique. Formation of the oxidized pyridine derivative was observed for all the studied DHPs, except for one compound, which showed very fast degradation and formation of a second photoproduct. Pharmacological tests on the molecules showed a good muscle relaxing eff ect, with a mechanism similar to that of nifedipine, however, proving to be more stable to light.

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“…A variety of methods including photolysis [17,18], adsorption [19][20][21], and advanced oxidation process [22,23] have been developed to remove antibiotics. However, photolysis process greatly relies on adequate illumination or involve addition of catalysts, adsorption process is limited due to poor adsorption capacity towards low-concentration antibiotics, and advanced oxidation process involves catalysts or a great deal of reagents that lead to the secondary pollution.…”

Section: Introductionmentioning

confidence: 99%