Kinetic studies on the aggregation behavior of phosphatidylcholines and their analogs

Abstract

Phosphatidylcholines (Ln's) and their neutral analogs 1,2-diacyl-sn-glycerol-3-phosphc~ ric acid bromoethyl esters (Pn's) have been found to exhibit different aggregation behaviors brought about by hydrophobic-lipophilic interactions (HLI) by means of kinetic probe in MeOH-H20 binary aquiorganic systems. The effects of the structure and the environment on the interesting aggregation of the amphiphilic molecules are discussed. Phosphat idylcholines 251 ~ membrane-directed activities. OC I01 ( C H Z~D C H J OClOl ICHZ)~-PCHJ -[ 'I k,,, the hydrolytic rate constant of C12 alone, was also obtained.