Kinetic study on hemipenta hydrate risedronate monosodium in batch crystallization by cooling mode

Characterization of a New Solvate of Risedronate

“…The solubility of sodium risedronate hemipentahydrate in water was previously found to be 43.3 :g/mL at 20 • C. 39 In a pilot test, the sodium risedronate acetic acid disolvate was dissolved in 0.1 mol sodium hydroxide solution, showing a much better dissolution than sodium risedronate hemi-pentahydrate under the same conditions. Subsequently, tests in media more relevant to physiological performance were conducted.…”

Real-Time Analysis to Evaluate Crystallization Processes

“…Figure 2 presents a schematic view of the Mettler Toledo FBRM probe. Just as with the ATR-FTIR technique, the FBRM is a well-established method of monitoring crystallization processes (Sun et al, 2010;Barrett & Glennon, 2002;Czapla et al, 2010;Sheikhzadeh et al, 2008;Nguyen & Kim, 2008).…”

Study on growth kinetics of phosphoric acid hemihydrate using FBRM

“…The dependence of the growth rate on the supersaturation solubility in batch crystallization process is generally of the form [11,12]:…”

“…5. Unlike other ordinate of mean chord length [3,4,11], the mean size is used as an ordinate in Fig. 5.…”

“…(5), is 1.07. When m= 1, the onedimension crystal growth will be controlled by the diffusion following the gradient concentration; and when m= 2, the twodimension crystal growth is controlled by the surface integration from spreading the surface such as spiral growth, volume diffusion-controlled growth and 2D nucleation-mediated growth mechanism; when m =3, the third-dimension crystal growth is controlled by the polynuclei growth and the growth takes place by the integration of nuclei or small particles due to the interaction and attrition [11]. So it can illustrate that the growth of phosphoric acid hemihydrate crystal is mainly controlled by the diffusion following the gradient concentration.…”