Kinetics and modelling of cell growth and substrate uptake inCentella asiatica cell culture

Omar, Rozita; Abdullah, Maha; Hasan, M. A.; Mohamad, Rosfarizan; Marziah, M.

doi:10.1007/bf02932034

Cited by 17 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The logistic equation describes the growth of a simple population in a confined space, where resources are limited [22]. Due to the bacteria having different growth curves in different fermentation environments [27], the dynamics equation was fitted at the conditions of revolving speed (RS 80 r/min, 130 r/min, 200 r/min), temperature (T 10 °C, 20 °C, 30 °C), and bacterial load (IS 2 mL, 3 mL, 4mL), based on the optimal medium: dXdt=μmX(1−XXm)…”

Section: Methodsmentioning

confidence: 99%

Medium Optimization and Fermentation Kinetics for κ-Carrageenase Production by Thalassospira sp. Fjfst-332

Guo

Zhang

et al. 2016

Molecules

View full text Add to dashboard Cite

Effective degradation of κ-carrageenan by isolated Thalassospira sp. fjfst-332 is reported for the first time in this paper. It was identified by 16S rDNA sequencing and morphological observation using Transmission Electron Microscopy (TEM). Based on a Plackett-Burman design for significant variables, Box-Behnken experimental design and response surface methodology were used to optimize the culture conditions. Through statistical optimization, the optimum medium components were determined as follows: 2.0 g/L κ-carrageenan, 1.0 g/L yeast extract, 1.0 g/L FOS, 20.0 g/L NaCl, 2.0 g/L NaNO 3 , 0.5 g/L MgSO 4 ·7H 2 O, 0.1 g/L K 2 HPO 4 , and 0.1 g/L CaCl 2 . The highest activity exhibited by Thalassospira sp. fjfst-332 was 267 U/mL, which makes it the most vigorous wild bacterium for κ-carrageenan production. In order to guide scaled-up production, two empirical models-the logistic equation and Luedeking-Piretequation-were proposed to predict the strain growth and enzyme production, respectively. Furthermore, we report the fermentation kinetics and every empirical equation of the coefficients (α, β, X 0 , X m and µ m ) for the two models, which could be used to design and optimize industrial processes.

show abstract

Section: Methodsmentioning

confidence: 99%

Medium Optimization and Fermentation Kinetics for κ-Carrageenase Production by Thalassospira sp. Fjfst-332

Guo

Zhang

et al. 2016

Molecules

View full text Add to dashboard Cite

show abstract

“…Jolicoeur et al () proposed a structured model for a HR and fungus symbiosis system, focusing on nutrient (especially phosphate) concentrations and species interactions. The publication of Omar et al () contained the comparison of different mathematical approaches (Monod, Logistic, and Gompertz) for Centella asiatica (Asiatic pennywort) SU in shake flasks and a stirred tank reactor. Another model for C. roseus was invented by Leduc et al () containing a detailed analysis on metabolic regulation and cell nutrition.…”

Section: Other Models Worth Mentioningmentioning

confidence: 99%

Modeling of plant in vitro cultures: Overview and estimation of biotechnological processes

Maschke

Geipel

Bley

2014

Biotech & Bioengineering

View full text Add to dashboard Cite

Plant cell and tissue cultivations are of growing interest for the production of structurally complex and expensive plant-derived products, especially in pharmaceutical production. Problems with up-scaling, low yields, and high-priced process conditions result in an increased demand for models to provide comprehension, simulation, and optimization of production processes. In the last 25 years, many models have evolved in plant biotechnology; the majority of them are specialized models for a few selected products or nutritional conditions. In this article we review, delineate, and discuss the concepts and characteristics of the most commonly used models. Therefore, the authors focus on models for plant suspension and submerged hairy root cultures. The article includes a short overview of modeling and mathematics and integrated parameters, as well as the application scope for each model. The review is meant to help researchers better understand and utilize the numerous models published for plant cultures, and to select the most suitable model for their purposes.

show abstract

“…The fact that the logistic equation is a substrate‐independent equation has caused some controversy 22. Nevertheless, this equation has been widely used for characterizing the cell growth of various microorganisms in many fermentation systems 23, 24.…”

Section: Development Of Analytical Solutions For Ordinary Differentiamentioning

confidence: 99%

Effects of glucose and nitrogen source concentration on batch fermentation kinetics of Lactococcus lactis under hemin‐stimulated respirative condition

Razvi

Zhang

Lan

2008

Biotechnology Progress

View full text Add to dashboard Cite

Analytical solutions to the ordinary differential equations governing the kinetics of cell growth, substrate utilization, and product formation of batch fermentation processes were derived and used to study the kinetics of the hemin-stimulated respiratory cultivation of Lactococcus lactis at varied initial glucose concentrations and nitrogen source concentrations. Studies revealed that initial glucose concentration varying in the range of 60 to 90 g/L had no significant substrate inhibitive effect. Furthermore, elevating the concentration of complex nitrogen sources while maintaining glucose concentration at 60% led to a high final biomass concentration of 6.6 g/L, substantially higher than that obtained with the basic medium, which was 4.1 g/L.

show abstract

Kinetics and modelling of cell growth and substrate uptake inCentella asiatica cell culture

Cited by 17 publications

References 22 publications

Medium Optimization and Fermentation Kinetics for κ-Carrageenase Production by Thalassospira sp. Fjfst-332

Medium Optimization and Fermentation Kinetics for κ-Carrageenase Production by Thalassospira sp. Fjfst-332

Modeling of plant in vitro cultures: Overview and estimation of biotechnological processes

Effects of glucose and nitrogen source concentration on batch fermentation kinetics of Lactococcus lactis under hemin‐stimulated respirative condition

Contact Info

Product

Resources

About