1978
DOI: 10.1038/bjc.1978.104
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Kinetics of changes in the crypts of the jejunal mucosa of dimethylhydrazine-treated rats

Abstract: Summary.-When symmetrical 1,2 dimethylhydrazine was administered to rats by weekly s.c. injection, 37% of the animals had developed small intestinal carcinomas after 21-27 weeks. These lesions were largely localized to duodenum and upper jejunum. At the same time there was a diffuse crypt hyperplasia in the jejunum which affected all the treated animals, not just those with neoplasms. This marked hyperplasia was preceded by a modest sustained crypt elongation which was seen soon after DMH injections began.In t… Show more

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Cited by 20 publications
(9 citation statements)
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“…We have also observed a reduction in growth fraction in the state of hyperplasia which precedes neoploia in the small bowel (Sunter et al, 1978c); in this preneoplastic state no change in T, was evident. It is clear from these observations that documentation of the precise sequence of cytokinetic changes during the neoplastic transformation of the crypt epithelium will lead to a better understanding of the early stages of tumorigenesis.…”
Section: Discussionsupporting
confidence: 52%
“…We have also observed a reduction in growth fraction in the state of hyperplasia which precedes neoploia in the small bowel (Sunter et al, 1978c); in this preneoplastic state no change in T, was evident. It is clear from these observations that documentation of the precise sequence of cytokinetic changes during the neoplastic transformation of the crypt epithelium will lead to a better understanding of the early stages of tumorigenesis.…”
Section: Discussionsupporting
confidence: 52%
“…This increase in crypt proliferation without change in MI is not unique (Snow & Altmann, 1983; Sunter et al . , 1978). As posited by Snow & Altmann (1983), an increase in crypt cells without change in MI can be explained by either an increase in the number of crypt basal stem cells or an increase in the number of divisions an upper crypt cell (sometimes referred to as a transit-amplifying cell) undergoes prior to differentiation.…”
Section: Application Of the Mode Of Action Frameworkmentioning
confidence: 99%
“…The greatest number of tumors are found in the descending colon, with the ascending colon being the second most common site (Weisburger et al, 1977;Deschner, 1974). The gastric stomach and duodenum, which display borderline repair capabilities for damage resulting from DMH, are infrequent but not unheard of sites for neoplasms, especially in rats (Zedeck and Brown, 1977;Sunter et al, 1978;Celik et al, 1981). The remaining Gl tissues, which demonstrate significant DMH-induced DNA repair capacity, rarely develop tumors (Weisburger et al, 1977;Deschner, 1974;Clapp et al, 1979).…”
Section: Discussionmentioning
confidence: 99%