Kingʼs Score: an accurate marker of cirrhosis in chronic hepatitis C

Abstract

The King's Score is a simple and accurate index for predicting cirrhosis in chronic hepatitis C. Patients with a score of less than 16.7 have a low risk of cirrhosis.

King’s Score may be More Effective in the Determination of Severe Fibrosis in Chronic Hepatitis B Infections

“…This can be explained by the greater number of patients with mild fibrosis being included in this study. As with other studies, the method selectivity increased as the cut-off value used increased (5,6,7,8).…”

“…Formula APRI (AST, upper limit of normal) / platelet count (10 9 / L) x 100 (6), GUCI <0.2 (7), King's score ≥12.3 (8), and FibroQ score <1.6 (9). For marked fibrosis, the following cut-off values were determined by the same researchers: >1.5, >3.25, ≥1.0, ≥16.7, and ≥1.6 for the APRI, FIB-4, GUCI, King's score, and FibroQ score, respectively.…”

“…In this study, among the noninvasive biochemical markers available, the AST-to-platelet ratio index (APRI), Fibrosis-4 (FIB-4) index, Goteborg University Cirrhosis Index (GUCI), King's score, FibroQ score, AST to ALT ratio (AAR), Bonacini Cirrhosis Discriminant Score (CDS), and age-platelet index (AP) were used (5,6,7,8,9,10,11,12). The formulas for these methods are shown in Table 1.…”

The predictive value of noninvasive serum markers of liver fibrosis in patients with chronic hepatitis C

“…Platelet count (7), AST-ALT ratio (AAR) (8), AST-platelet ratio index (APRI) (9), fibrosis-4 (FIB-4) index (10), cirrhosis discriminant score (CDS) (11), age-platelet index (AP index) (12), Goteborg University Cirrhosis Index (GUCI) (13), King's score (14), and FibroQ (15) were calculated according to the published or patented formulae. The platelet count cut-off value was considered to be <150×10 3 μ/L (7).…”

Prospective validation of a non-invasive index for predicting liver fibrosis in hepatitis C virus-infected liver transplant recipients

“…An initial study of 602 nontransplant patients with CHC gave rise to the King's score, which uses the following simple parameters: the patient's age, aspartate aminotransferase level, platelet level, and international normalized ratio. 3 Subsequently, we applied this test to the setting of liver transplantation and analyzed retrospectively 185 patients who underwent liver transplantation for CHC. The median age of the study group was 53 years, and 76% of the patients were male.…”