2024
DOI: 10.1186/s12014-024-09457-w
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Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients

Tomonori Kaneko,
Sally Ezra,
Rober Abdo
et al.

Abstract: SARS-CoV-2 infection triggers extensive host immune reactions, leading to severe diseases in certain individuals. However, the molecular basis underlying the excessive yet non-productive immune responses in severe COVID-19 remains incompletely understood. In this study, we conducted a comprehensive analysis of the peripheral blood mononuclear cell (PBMC) proteome and phosphoproteome in sepsis patients positive or negative for SARS-CoV-2 infection, as well as healthy subjects, using quantitative mass spectromet… Show more

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