KIR gene presence/absence polymorphisms and global diversity in the Kirgiz ethnic minority and populations distributed worldwide

Wang, Hongdan; Jin, Xiaoye; Guo, Yuxin; Zhang, Qian; Zhang, Yu-Wei; Wang, Xin; Zhu, Bofeng

doi:10.1007/s11033-018-4563-3

Cited by 2 publications

(1 citation statement)

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“…The above mentioned researches demonstrated that Kirgiz group had the relatively close genetic distances with Kazakh and Hui groups based on autosomal InDel genetic markers. Wang et al (2019) explored the genetic diversity of Kirgiz group based on the presence/absence polymorphisms of killer cell immunoglobulin like receptor genes. And the research indicated that the Kirgiz group represented small genetic differences with populations speaking the same family language.…”

Section: Introductionmentioning

confidence: 99%

Genetic Background of Kirgiz Ethnic Group From Northwest China Revealed by Mitochondrial DNA Control Region Sequences on Massively Parallel Sequencing

Wang

Chen

et al. 2022

Front. Genet.

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The mitochondrial DNA (mtDNA) has been used to trace population evolution and apply to forensic identification due to the characteristics including lack of recombination, higher copy number and matrilineal inheritance comparing with nuclear genome DNA. In this study, mtDNA control region sequences of 91 Kirgiz individuals from the Northwest region of China were sequenced to identify genetic polymorphisms and gain insight into the genetic background of the Kirgiz ethnic group. MtDNA control region sequences of Kirgiz individuals presented relatively high genetic polymorphisms. The 1,122 bp sequences of mtDNA control region could differ among unrelated Kirgiz individuals, which suggested the mtDNA control region sequences have a good maternal pedigree tracing capability among different Kirgiz individuals. The neutrality test, mismatch distribution, Bayesian phylogenetic inference, Bayesian skyline analysis, and the median network analyses showed that the Kirgiz group might occurred population expansion, and the expansion could be observed at about ∼53.41 kilo years ago (kya) when ancestries of modern humans began to thrive in Eurasia. The pairwise population comparisons, principal component analyses, and median network analyses were performed based on haplogroup frequencies or mtDNA control region sequences of 5,886 individuals from the Kirgiz group and the 48 reference populations all over the world. And the most homologous haplotypes were found between Kirgiz individuals and the East Asian individuals, which indicated that the Kirgiz group might have gene exchanges with the East Asian populations.

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Section: Introductionmentioning

confidence: 99%