KL-6, a human MUC1 mucin, is expressed early in premature lung

Sun, Aping; Ohtsuki, Yuji; Fujita, Jiro; Ishida, Toshihiko; Yoshinouchi, Takeo; Kohno, Nobuoki

doi:10.1016/s0954-6111(03)00124-0

Cited by 21 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…KL-6, a mucin-like high-molecular-weight glycoprotein, has been shown to correlate with activity of interstitial pneumonia [14]. Previous studies showed higher bronchial reactivity and anomalous pulmonary venous return in TS patients [15, 16], but there are no reports showing an association between TS and interstitial lung diseases or KL-6.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed higher bronchial reactivity and anomalous pulmonary venous return in TS patients [15, 16], but there are no reports showing an association between TS and interstitial lung diseases or KL-6. Sun et al [14] reported that KL-6 was expressed in the lungs of premature neonates and infants with gestational age from 23 to 40 weeks. The sustained high level of KL-6 in the present case may be related to a possible prematurity of the lungs in TS.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Alterations of the Cerebral White Matter in a Middle-Aged Patient with Turner Syndrome: An MRI Study

Tanji

Nakajima²,

Wada³

et al. 2012

Case Rep Neurol

View full text Add to dashboard Cite

A 52-year-old woman with intellectual disability was admitted to the hospital due to pneumonia. MRI of her brain showed diffuse hyperintensities on T₂-weighted and fluid attenuated inversion recovery images in the bilateral cerebral white matter. Laboratory examination revealed sustained high levels of serum KL-6. Karyotyping revealed partial monosomy of the X chromosome. This is the first case showing diffuse white matter lesions in the brain, and sustained high levels of serum KL-6 in Turner syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alterations of the Cerebral White Matter in a Middle-Aged Patient with Turner Syndrome: An MRI Study

Tanji

Nakajima²,

Wada³

et al. 2012

Case Rep Neurol

View full text Add to dashboard Cite

show abstract

“…A previous immunohistochemical study revealed that type II cells obtained from premature lungs expressed KL-6 as early as 23 wk GA (16). We previously found an increase of the plasma KL-6 level in infants with BPD, suggesting that KL-6 was an early marker of BPD and an indicator of its severity (17).…”

mentioning

confidence: 84%

Plasma KL-6 Predicts the Development and Outcome of Bronchopulmonary Dysplasia

et al. 2006

View full text Add to dashboard Cite

Circulating KL-6 is a specific indicator of pulmonary injury affecting the alveolar epithelium and interstitium. Our preliminary study suggested the usefulness of plasma KL-6 as a marker of bronchopulmonary dysplasia (BPD). To confirm the diagnostic value of KL-6 for BPD as well as to determine the reference range, we conducted a larger prospective study in 135 preterm infants Ͻ32 wk GA. Among the infants without oxygen dependence at a postconceptional age of 36 wk, the plasma KL-6 level showed no significant association with GA at any time. Among 42 infants Ͻ28 wk GA, plasma KL-6 levels were significantly higher in those with moderate/ severe BPD compared with those with no/mild BPD. A plasma level of 199 U/mL at 1 wk or 232 U/mL at 2 wk was an excellent predictor of moderate/severe BPD Ͻ28 wk GA (positive predictive value of 83% and 80%, respectively). Unlike nonspecific markers of inflammation or fibrosis, KL-6 objectively reflects the severity of pulmonary injury irrespective of the treatment or the radiographic changes. Therefore, not only as a good marker, measurement of KL-6 may also help to provide new insights into the pathogenesis of BPD.

show abstract

“…20–22 Moreover, a possible role of MUC1 in cellular adhesion mechanisms during organogenesis has been proposed. 21 Taking into account these reports and also the adherent and anti-adherent properties of Muc1/MUC1 as well as its relationship with signal transduction, it would be expected that Muc1 appears early in epithelial development in mammalian species.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical evidence of Muc1 expression during rat embryonic development

et al. 2010

View full text Add to dashboard Cite

During embryonic development, studies on mouse and human embryos have established that Muc1/MUC1 expression coincides with the onset of epithelial sheet and glandular formation. This study aimed therefore at evaluating the temporal and spatial expression of Muc1 at different stages of rat development. In this report, 80 animals were included: 64 rat foetuses at 13, 14, 15, 16, 17, 18, 19 and 20 days of gestation from pregnant females (WKAH/Hok), 8 embryos each stage. Standard immunohistochemistry was performed using anti-MUC1 cytoplasmic tail polyclonal antibody (CT33). The reaction was considered positive when more than 5% of the cells were stained; reaction patterns were: L = linear, membrane, C = cytoplasmic and M = mixed; nuclear staining was also recorded. Intensity was graded as negative (−), low (+), moderate (++) and strong (+++). Muc1 expression was observed with a low intensity on 13th day (13 D) in the stomach, lung and kidney; at 14 d, small intestine and pancreas were also reactive; at 16 D, liver and esophagus and at 18 D, trachea and salivary glands. During the development, intensity increased while the pattern of expression changed: at the first days of gestation, it was predominantly linear and apical while during further development an increase in cytoplasmic expression was observed. Trachea, stomach, kidney and lung epithelia were the more reactive tissues. In specimens belonging to neonates and adults, all tissues analyzed showed similar Muc1 expression. The findings of this study assess that Muc1 is highly expressed in the epithelial rat embryonic development.

show abstract

KL-6, a human MUC1 mucin, is expressed early in premature lung

Cited by 21 publications

References 24 publications

Alterations of the Cerebral White Matter in a Middle-Aged Patient with Turner Syndrome: An MRI Study

Alterations of the Cerebral White Matter in a Middle-Aged Patient with Turner Syndrome: An MRI Study

Plasma KL-6 Predicts the Development and Outcome of Bronchopulmonary Dysplasia

Immunohistochemical evidence of Muc1 expression during rat embryonic development

Contact Info

Product

Resources

About