Klotho and Abdominal Aortic Calcifification: Results from NHANES 2013-2014

Abstract

Objective:Background and purposes：Abdominal aortic calcification (AAC) has been considered as an excellent predictor of cardiovascular disease (CVD) events. Klotho is an important anti-aging substance, but the relationship between Klotho level and AAC has not been studied before.This research aimed to dig the association between S-Klotho and AAC in middle-aged and elderly people in the United States.Methods: Cross-sectional information were collected from the National Health and Nutrition examination Survey (NHANES) from 2013 to 2014, which surveyed 1364 males and females aged 40 and over. In order to evaluate the correlation between klotho and AAC, multivariate Logistic regression analysis was carried out. Fitting smooth curve and generalized additive model. We found that after adjusting several potential confounding factors, we found that there was a U-shaped dose-response relationship between klotho and AAC, and the inflection point of 1282.3pg/ml was calculated by two-stage linear regression model.ConclusionIn a typical sample of American adults, individuals with low or high levels of klotho have an increased risk of AAC. Although low klotho levels are widely considered harmful, these outcomes emphasize the demand for potential adverse health consequences of high klotho levels.