Klotho and smoking – An interplay influencing the skeletal muscle function deficits that occur in COPD

Patel, Mehul S.; Donaldson, Anna; Lewis, Amy; Natanek, Samantha A.; Lee, J.Y.; Andersson, Yvonne M.; Haji, Gulam; Jackson, Sonya; Bolognese, Brian; Foley, Joseph; Podolin, Patricia L.; Bruijnzeel, P. L. B.; Hart, Nicholas; Hopkinson, Nicholas S; Man, William D.‐C.; Kemp, Paul R.; Polkey, Michael I.

doi:10.1016/j.rmed.2016.02.004

Cited by 28 publications

(12 citation statements)

References 36 publications

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“…Three studies (case-control, cross-sectional, and prospective cohort) investigated the interaction of smoking and obstructive lung disease on skeletal muscles. Those studies found smoking in the presence of obstructive lung disease to be significantly associated with increased muscle injury [ 212 ] and lower weight and lean mass [ 219 ]; however, smoking, regardless of patient spirometry status, was the only independent variable associated with lower quadriceps Klotho levels [ 213 ].…”

Section: Resultsmentioning

confidence: 99%

The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review

Al-Bashaireh

Haddad

Weaver

et al. 2018

Journal of Environmental and Public Health

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This systematic review explored associations between smoking and health outcomes involving the musculoskeletal system. AMSTAR criteria were followed. A comprehensive search of PubMed, Web of Science, and Science Direct returned 243 articles meeting inclusion criteria. A majority of studies found smoking has negative effects on the musculoskeletal system. In research on bones, smoking was associated with lower BMD, increased fracture risk, periodontitis, alveolar bone loss, and dental implant failure. In research on joints, smoking was associated with increased joint disease activity, poor functional outcomes, and poor therapeutic response. There was also evidence of adverse effects on muscles, tendons, cartilage, and ligaments. There were few studies on the musculoskeletal health outcomes of secondhand smoke, smoking cessation, or other modes of smoking, such as waterpipes or electronic cigarettes. This review found evidence that suggests tobacco smoking has negative effects on the health outcomes of the musculoskeletal system. There is a need for further research to understand mechanisms of action for the effects of smoking on the musculoskeletal system and to increase awareness of healthcare providers and community members of the adverse effects of smoking on the musculoskeletal system.

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Section: Resultsmentioning

confidence: 99%

The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review

Al-Bashaireh

Haddad

Weaver

et al. 2018

Journal of Environmental and Public Health

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“…Despite the three serum biomarkers exhibited no difference between the two groups, serum Klt, 25(OH)D and Hcy levels in male MSA patients were higher than those in male PD patients (Table ), indicating the difference of Klt, 25(OH)D and Hcy between MSA and PD patients was more significant in men. Subsequently, serum Klt, 25(OH)D and Hcy levels may be potential indicators for differentiating between MSA from PD patients in men …”

Section: Discussionmentioning

confidence: 99%

Serum Klotho, vitamin D, and homocysteine in combination predict the outcomes of Chinese patients with multiple system atrophy

et al. 2017

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“…Klotho is an anti-aging gene, which has been identified at reduced levels in patients with OSAS, type 2 diabetes mellitus, and in subjects who are smokers ( 20 , 26 , 27 ). High klotho expression levels in the plasma are associated with good response in patients with acute ischemia stroke ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Klotho alleviates chronic intermittent hypoxia‑induced genioglossus myocyte apoptosis by inhibiting endoplasmic reticulum stress

Xue

Ding

et al. 2021

Exp Ther Med

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Chronic intermittent hypoxia (CIH) has been shown to induce cell apoptosis in multiple organs of the human body. The present study aimed to assess the effects of exogenous klotho on CIH-induced genioglossus muscle injury, as well as the involvement of endoplasmic reticulum stress (ERS) in this process. A total of 36 adult C57BL/6 male mice were assigned to normoxia control (NC), CIH and CIH + klotho groups (n=12 mice/group). ELISA was performed to detect the level of klotho protein in the serum and in the genioglossus muscle tissue samples. Apoptosis was evaluated using the TUNEL assay. Reactive oxygen species (ROS) levels were quantified using a dihydroethidium assay kit, and the protein and mRNA levels of ERS-associated proteins (namely, glucoseregulated protein 78, C/EBP homologous protein, cleaved caspase-12 and cleaved caspase-3) in genioglossus samples were assessed using immunoblot assay and reverse transcription-quantitative PCR, respectively. Compared with the NC group, the quantities of klotho protein in the serum and genioglossus muscle tissue samples in the CIH group were significantly decreased, whereas the apoptotic rate, ROS levels and protein and mRNA levels of the ERS-associated proteins in the genioglossus muscle were significantly increased. Following supplementation with exogenous klotho protein, the klotho protein levels in the serum and genioglossus muscle tissue of mice were found to be markedly increased, and the apoptotic rate, ROS levels and protein and mRNA levels of the ERS-associated proteins in the genioglossus muscle were decreased compared with those in the CIH group. Taken together, the results of the present study have demonstrated that exogenous klotho may inhibit apoptosis of genioglossus myocytes in mice by inhibiting ROS-associated ERS.

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Klotho and smoking – An interplay influencing the skeletal muscle function deficits that occur in COPD

Cited by 28 publications

References 36 publications

The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review

The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review

Serum Klotho, vitamin D, and homocysteine in combination predict the outcomes of Chinese patients with multiple system atrophy

Klotho alleviates chronic intermittent hypoxia‑induced genioglossus myocyte apoptosis by inhibiting endoplasmic reticulum stress

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