Clinica Chimica Acta

2006

DOI: 10.1016/j.cca.2006.02.021

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Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese

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The Differences In the Aortic Calcification According To Dif1

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Cited by 56 publications

(44 citation statements)

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“…However, the comparable difference in the association between KLOTHO G-395A SNP and coronary heart disease may support this hypothesis. For example, the -395 A allele of the KLOTHO gene was considered to be a protective factor for coronary heart disease in a Korean population (Rhee et al, 2006a), but a risk factor in a Japanese population (Imamura et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The identification of SNPs in the human KLOTHO gene is currently one of the most active areas of research. So far, more than 10 SNPs have been identified in the human KLOTHO gene, and linked to fasting glucose (Rhee et al, 2006b), coronary artery disease (Imamura et al, 2006;Rhee et al, 2006a), stroke (Kim et al, 2006), bone mineral density (Kawano et al, 2002), and kidney stone (Telci et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals

Ll¹,

Ding²,

Dm³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We included 710 participants aged 93.5 ± 3.2 years in the analyses. The expression of the A allele of the KLOTHO G-395A polymorphism was significantly downregulated in the hypertension group compared to the control group (0.137 vs 0.200, P < 0.001). The genotype distribution of the G-395A polymorphism between the hypertension and control groups was significantly different in women and smokers, and not in men or non-smokers. The mean systolic blood pressure, percentage of hypertension, and percentage of isolated systolic hypertension was significantly higher in the group with the GG genotype than in the group with the GA+AA genotype. Subjects expressing the GA+AA genotype demonstrated a significantly lower risk of hypertension even after adjusting for age, gender, and other relevant risk factors compared to the population expressing the GG genotype (odds ratio, 0.68; 95% confidence interval: 0.49 to 0.95).The -395A allele of the KLOTHO gene may be a protective genetic factor for hypertension in the Chinese population.

“…However, the comparable difference in the association between KLOTHO G-395A SNP and coronary heart disease may support this hypothesis. For example, the -395 A allele of the KLOTHO gene was considered to be a protective factor for coronary heart disease in a Korean population (Rhee et al, 2006a), but a risk factor in a Japanese population (Imamura et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The identification of SNPs in the human KLOTHO gene is currently one of the most active areas of research. So far, more than 10 SNPs have been identified in the human KLOTHO gene, and linked to fasting glucose (Rhee et al, 2006b), coronary artery disease (Imamura et al, 2006;Rhee et al, 2006a), stroke (Kim et al, 2006), bone mineral density (Kawano et al, 2002), and kidney stone (Telci et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals

Ll¹,

Ding²,

Dm³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We included 710 participants aged 93.5 ± 3.2 years in the analyses. The expression of the A allele of the KLOTHO G-395A polymorphism was significantly downregulated in the hypertension group compared to the control group (0.137 vs 0.200, P < 0.001). The genotype distribution of the G-395A polymorphism between the hypertension and control groups was significantly different in women and smokers, and not in men or non-smokers. The mean systolic blood pressure, percentage of hypertension, and percentage of isolated systolic hypertension was significantly higher in the group with the GG genotype than in the group with the GA+AA genotype. Subjects expressing the GA+AA genotype demonstrated a significantly lower risk of hypertension even after adjusting for age, gender, and other relevant risk factors compared to the population expressing the GG genotype (odds ratio, 0.68; 95% confidence interval: 0.49 to 0.95).The -395A allele of the KLOTHO gene may be a protective genetic factor for hypertension in the Chinese population.

“…Gene polymorphisms in KLOTHO, which encodes a hormone with anti-aging properties that is involved in phosphate regulation, were reported to be associated with bone mineral density and coronary artery disease in Asian population [34][35][36]. Polymorphisms in OPG gene, which is a decoy receptor for RANKL, were reported to be associated with osteoporosis and increased risk of coronary artery disease and vascular morphology [22,37].…”

Section: The Differences In the Aortic Calcification According To Difmentioning

confidence: 99%

The relationship between Receptor Activator of Nuclear Factor-.KAPPA.B Ligand (RANKL) gene polymorphism and aortic calcification in Korean women

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et al. 2010

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“…8) However, another study concluded KLOLTHO G395A polymorphism had no relation with CAD in a Korean population. 9) Therefore, it has become imperative to evaluate the real contribution of the KLOTHO gene variant to CAD risk and the association between KLOTHO and coronary arterial calcification.…”

mentioning

confidence: 99%

KLOTHO Gene Polymorphism Is Associated With Coronary Artery Stenosis but Not With Coronary Calcification in a Korean Population

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et al. 2009

Int. Heart J.

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SummaryExperimental studies have demonstrated KLOTHO gene polymorphism might be associated with vascular atherosclerosis and calcification. However, the impact of this genetic variant on human coronary arteries still remains to be elucidated. We investigated the effect of a KLOTHO gene variant on coronary artery stenosis and calcification. Four hundred and thirty-four patients referred for chest pain were enrolled. All the patients underwent coronary angiography and were investigated for polymorphism of the KLOTHO G395A gene. Coronary artery disease (CAD) was defined as ≥ 50% diameter stenosis in at least one coronary artery. The other patients were considered to be controls. Homozygotes or heterozygotes for G395A were significantly more common in the CAD patients than in the controls (30.2% versus 21.5%, P = 0.039). In the subgroup aged < 60 years, the G395A mutant was more frequent in CAD than in control (35.3% versus 18.8%, P = 0.016), but in patients ≥ 60 years, there was no difference (28.0% versus 24.1%, P = 0.473). Using multivariate analysis, we identified the KLOTHO gene G395A mutant as an independent risk factor of CAD (OR 1.712, 95% CI [1.066-2.749], P = 0.026). The frequency of the KLOTHO gene G395A mutant was not different between the calcified and noncalcified coronary artery groups (25.7%, 26.4%, respectively, P = 0.861) and an A allele carrier state was not an independent risk factor of coronary artery calcification. In conclusion, the KLOTHO gene G395A allele carrier state may be associated with CAD but not with coronary artery calcification in this Korean population. (Int Heart J 2009; 50: 23-32)

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