Kluver-Bucy syndrome: A morbid consequences of post herpes simplex encephalitis

Halder, Ajay; Mandal, Uday Sankar; Haldar, Subrata; Biswas, Abhinanda

doi:10.4103/2348-3334.165742

Cited by 3 publications

(5 citation statements)

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“…This virus usually has a predilection for the temporal lobes. Acyclovir is the standard treatment for HSE and given for 14-21 days, and is best administered before the patient becomes comatose [4][5][6] . In our patient, CSF analysis was not possible, but the typical changes seen on MRI, fever and seizures made the diagnosis of HSE, which was later confirmed by a positive HSV test.…”

Section: Discussionmentioning

confidence: 99%

“…KBS was first described in humans (the first diagnosis was made in monkeys in 1937) in a patient who had undergone bilateral temporal lobectomy for epilepsy in 1955 [3] . The aetiology of KBS is varied and includes herpes simplex encephalitis (HSE), temporal lobe epilepsy, Alzheimer's disease, head trauma, toxoplasmosis, Pick's disease and cerebrovascular disease [4,5] . The common pathology of these aetiologies is bilateral destruction or dysfunction of the medial temporal lobe [2,5] .…”

Section: Introductionmentioning

confidence: 99%

“…The aetiology of KBS is varied and includes herpes simplex encephalitis (HSE), temporal lobe epilepsy, Alzheimer's disease, head trauma, toxoplasmosis, Pick's disease and cerebrovascular disease [4,5] . The common pathology of these aetiologies is bilateral destruction or dysfunction of the medial temporal lobe [2,5] . We present the case of a 21-year-old man who developed KBS following HSE, which is very rare.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Kluver-Bucy Syndrome: A Rare Complication of Herpes Simplex Encephalitis

Costa¹,

Fontes²,

Mendes³

et al. 2021

European Journal of Case Reports in Internal Medicine

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Kluver-Bucy syndrome (KBS) is a characterized by a group of cognitive dysfunctions that include hypersexuality, placidity, hyperorality, memory deficits and hypermetamorphosis. This syndrome is often seen in pathological states that destroy the temporal lobes, normally bilaterally. Herpes simplex encephalitis (HSE) is one of the causes of KBS, as the herpes virus can cause dysfunction/destruction of the temporal lobes. KBS is a very rare syndrome, with just a few cases described in the literature. We present the case of a 21-year-old-man who was diagnosis with KBS after HSE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kluver-Bucy Syndrome: A Rare Complication of Herpes Simplex Encephalitis

Costa¹,

Fontes²,

Mendes³

et al. 2021

European Journal of Case Reports in Internal Medicine

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“…Multiple papers have described the pathophysiology of KBS, including Alzheimer’s disease, herpes simplex encephalitis, stroke, and head trauma [ 2 , 3 ]. Herpes simplex virus is known to cause dysfunction of the temporal lobes.…”

Section: Reviewmentioning

confidence: 99%

“…Kluver-Bucy Syndrome (KBS) is a rare neuropsychiatric disorder characterized by hyperorality, hypersexuality, bulimia, visual agnosia, and amnesia due to lesions affecting bilateral temporal lobes [ 1 ]. Kluver-Bucy Syndrome has a variety of causes, including stroke, herpes simplex encephalitis, Alzheimer’s disease, and head trauma [ 2 , 3 ]. Current treatments for KBS include symptomatic management with antipsychotics, mood stabilizers, carbamazepine, and selective serotonin reuptake inhibitors (SSRIs) [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

The 100 Most Cited Kluver-Bucy Research Articles: A Bibliometric Analysis

Janku,

Engel,

Patel

et al. 2023

Cureus

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Kluver-Bucy Syndrome (KBS) is a rare neuropsychiatric disorder characterized by hyperorality, hypersexuality, bulimia, visual agnosia, and amnesia due to lesions affecting bilateral temporal lobes. It is attributed to a multitude of causes, including stroke, herpes simplex encephalitis, Alzheimer’s disease, and head trauma. Current treatments for KBS include symptomatic management with antipsychotics, mood stabilizers, carbamazepine, and selective serotonin reuptake inhibitors. The bibliometric analysis was done to reflect the relevance and understanding of KBS in recent literature. The SCOPUS database was utilized to conduct a search for all articles with the terms “Kluver-Bucy” and “Kluver Bucy” from January 1, 1955 (the first available articles from the search) to February 1, 2023. The parameters included in this analysis were article title, citation numbers, citations per year, authors, institutions, publishing journals, country of origin, Source Normalized Impact per Paper, and Scopus CiteScore. Since 1937, when Kluver-Bucy Syndrome was first defined, the publications on KBS have steadily increased, with up to six publications a year in 2002. The most common institutions were SUNY Upstate Medical University, VA Medical Center, and the State University of New York (SUNY) System. Seven of these papers were published in Neurology . Almost 75% of the articles were published in journals of medicine and neuroscience. This is the first bibliometric analysis to evaluate the most influential publications about Kluver-Bucy Syndrome. A majority of the research is case-based and there is a dearth of clinical trials to identify the exact pathophysiology and physiotherapy management, possibly owing to the rarity of the disease. Our research suggests that there may be a significant overlap between Sanfilippo syndrome and KBS, suggesting that refined guidelines for establishing diagnosis may be required for children. Our study could bring a renewed interest in this field and lead to additional research focused on understanding the pathophysiology of KBS in order to promote the development of novel diagnostics and treatment.

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Virus-Induced Voracity: Uncovering Hyperphagia Post-Herpes Simplex Virus Type 1

Mitra,

Bhuyan,

Vivek

et al. 2024

Case Rep Neurol

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Herpes simplex virus type 1 (HSV-1) is the leading cause of sporadic fatal encephalitis, typically presenting with temporal lobe abnormalities. We report a 25-year-old woman with a 10-day history of fever, headache, and vomiting, progressing to confusion, visual hallucinations and drowsiness. She had a history of meningoencephalitis at age eight and well-controlled focal seizures. Upon admission, her GCS score was E3V5M3, and the MRI showed hyperintensities in both temporal lobes with diffusion restriction. EEG indicated generalised slowing, and CSF analysis revealed lymphocytic pleocytosis with elevated protein levels. Viral encephalitis was suspected, and intravenous acyclovir was initiated. CSF PCR confirmed HSV-1. By the end of 1st week, she became afebrile and showed improved awareness but developed hyperphagia for both edible and non-edible objects. She received 21 days of acyclovir with significant improvement in consciousness but only partial improvement in over eating. HSV-1 affects the bilateral medial temporal lobes, insular cortex, and cingulate gyrus. An MRI confirmed these findings in this patient. Hyperphagia, a rare complication of HSV encephalitis, is a part of Kluver-Bucy Syndrome (KBS), typically associated with other cognitive dysfunctions. Despite early treatment, hyperphagia persisted partially, emphasising the need for rapid diagnosis and treatment to prevent severe outcomes. The case highlights that acute onset hyperphagia can be an isolated complication of HSV encephalitis, requiring tailored therapeutic strategies. Follow-up showed significant weight gain with moderate improvement in hyperphagia, underscoring the challenges in managing this condition.

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Kluver-Bucy syndrome: A morbid consequences of post herpes simplex encephalitis

Cited by 3 publications

References 1 publication

Kluver-Bucy Syndrome: A Rare Complication of Herpes Simplex Encephalitis

Kluver-Bucy Syndrome: A Rare Complication of Herpes Simplex Encephalitis

The 100 Most Cited Kluver-Bucy Research Articles: A Bibliometric Analysis

Virus-Induced Voracity: Uncovering Hyperphagia Post-Herpes Simplex Virus Type 1

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