2014
DOI: 10.4161/cc.28607
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Knockdown of astrocyte elevated gene-1 (AEG-1) in cervical cancer cells decreases their invasiveness, epithelial to mesenchymal transition, and chemoresistance

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Cited by 48 publications
(46 citation statements)
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“…The over-expression of AEG1 downregulates E-cadherin (epithelial marker) and up-regulates Vim1, SNAI, and N-cadherin (mesenchymal markers). Some studies have suggested that the knockdown of AEG-1 could decrease EMT and resistance to paclitaxel and cisplatin chemotherapy in cervical cancer cells [33]. Table 1 lists the genes and miRNAs that are involved in chemoresistance and EMT in cervical cancer.…”
Section: Oncogenes and Emt In Cervical Cancermentioning
confidence: 99%
“…The over-expression of AEG1 downregulates E-cadherin (epithelial marker) and up-regulates Vim1, SNAI, and N-cadherin (mesenchymal markers). Some studies have suggested that the knockdown of AEG-1 could decrease EMT and resistance to paclitaxel and cisplatin chemotherapy in cervical cancer cells [33]. Table 1 lists the genes and miRNAs that are involved in chemoresistance and EMT in cervical cancer.…”
Section: Oncogenes and Emt In Cervical Cancermentioning
confidence: 99%
“…6A and C, when the Linc00152 was knocked down, the mesenchymal markers N-cadherin and Vimentin were down-regulated, and the epithelial marker E-cadherin protein were up-regulated, whereas the EMT related transcriptional factors Snail and Slug were not altered remarkably. Additionally, we examined the level of AEG-1 expression since AEG-1 was established as the oncogenic proteins associating with cancer metastasis and invasion, and our previous studies found AEG-1 reduction could inhibit invasion, EMT in cervical cancer 26 and suppress cell migration in hepatocellular carcinoma. 27 We found that AEG-1 protein decreased with Linc00152 depletion.…”
Section: Linc00152 Depletion Represses Epithelial-to-mesenchymal Tranmentioning
confidence: 99%
“…Metastasis results in treatment failure and death (6). Epithelial-mesenchymal transition (EMT) has been implicated as the key factor in CSCs transformation (7,8). EMT has been shown to induce reversion to a CSC-like phenotype, linking CSCs and EMT (9,10).…”
mentioning
confidence: 99%