Knockdown of long non-coding RNA <i>LCPAT1</i> inhibits autophagy in lung cancer

Yu, Xiao; Ye, Xiaofei; Lin, Hongyan; Feng, Na; Gao, Sumeng; Zhang, Xiaohong; Wang, Yu; Yu, Herbert; Deng, Xiaobei; Qian, Biyun

doi:10.20892/j.issn.2095-3941.2017.0150

Cited by 27 publications

(8 citation statements)

References 32 publications

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“… 26 LCPAT1 has been reported to promote lung cancer cell proliferation, and it participates in DNA damage. 17 , 27 To our knowledge, whether LCPAT1 is involved in BC regulation remains totally unclear. Our study reveals that LCPAT1 is upregulated in BC cells.…”

Section: Discussionmentioning

confidence: 99%

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lncRNA LCPAT1 Upregulation Promotes Breast Cancer Progression via Enhancing MFAP2 Transcription

Gong

Dong

Niu

et al. 2020

Molecular Therapy - Nucleic Acids

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The importance of long noncoding RNA (lncRNA) in tumorigenesis has been supported by increasing evidence in recent years. However, the mechanism linking lncRNA function with cancer progression remains poorly understood. lncRNA LCPAT1 plays a role in lung cancer. However, how it works in breast cancer (BC) is largely unclear. In this study, we found that LCPAT1 was highly expressed in BC tissues and cell lines. High LCPAT1 expression predicted a low survival rate in BC patients. LCPAT1 promoted BC cell proliferation, migration, and invasion while inhibiting apoptosis in vitro . LCPAT1 knockdown suppressed BC growth in vivo and vice versa. LCPAT1 interacted with RBBP4 and recruited it to the MFAP2 (microfibril-associated protein 2) promoter and then activated MFAP2 transcription. Restoration of MFAP2 rescued the effects of LCPAT1 knockdown in BC cells. In sum, LCPAT1 promotes BC progression through recruiting RBBP4 to initiate MFAP2 transcription.

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Section: Discussionmentioning

confidence: 99%

“…A previous study indicated that LCPAT1 regulates lung cancer. 17 However, other roles of LCPAT1 have not been explored. We found that LCPAT1 was highly expressed in BC tissues and correlated with poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

lncRNA LCPAT1 Upregulation Promotes Breast Cancer Progression via Enhancing MFAP2 Transcription

Gong

Dong

Niu

et al. 2020

Molecular Therapy - Nucleic Acids

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“…ATG12 is conjugated with ATG5 with the assistance of ATG7 to form the ATG5–ATG12 complex. LC3-I is finally transformed into LC3-II with the assistance of this complex, promoting autophagosome formation [ 27 – 29 ]. As mentioned above, autophagy plays different roles in tumors based on the type, stage, and genetic background of cancer [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer

Wei

Tang

et al. 2020

Journal of Oncology

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Purpose. Colorectal cancer is one of the most common malignant primary tumors, prone to metastasis, and associated with a poor prognosis. As autophagy is closely related to the development and treatment of colorectal cancer, we investigated the potential prognostic value of long noncoding RNA (lncRNA) associated with autophagy in colorectal cancer. Methods. In this study, we acquired information on the expression of lncRNAs in colorectal cancer from the Cancer Genome Atlas (TCGA) database and found that 860 lncRNAs were associated with autophagy-related genes. Subsequently, univariate Cox regression analysis was used to investigate 32 autophagy-related lncRNAs linked to colon cancer prognosis. Subsequently, eight of the 32 autophagy-related lncRNAs (i.e., long intergenic nonprotein coding RNA 1503 [LINC01503], ZEB1 antisense RNA 1 [ZEB1-AS1], AC087481.3, AC008760.1, AC073896.3, AL138756.1, AL022323.1, and TNFRSF10A-AS1) were selected through multivariate Cox regression analysis. Based on these autophagy-related lncRNAs, a risk signature was constructed, and the patients were divided into high- and low-risk groups. Results. The high-risk group’s overall survival time was significantly shorter than that of the low-risk group p < 0.0001 . Receiver operating characteristic curve analysis was performed to further confirm the validity of the model (area under the curve: 0.689). Moreover, multivariate regression suggested that the risk score was a significant prognostic risk factor in colorectal cancer. Gene set enrichment analysis showed that these gene sets are significantly enriched in cancer-related pathways, such as Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling. Conclusion. The risk signature of eight autophagy-related lncRNAs has prognostic potential for colorectal cancer. These autophagy-related lncRNAs may play a vital role in the biology of colorectal cancer.

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“…It is associated with larger tumor size, advanced TNM stage, excessive growth and apoptosis process of HCC cells and tissues through sponging tumor suppressor miR-30b-5p and inducing autophagy (Liu et al, 2016). Yu et al (2018), recently noticed LCPAT1 lncRNA in LC which is directly regulated with autophagic flux. The overexpression of LCPAT1 and LC3 was found to be in both LC cells and tumor samples which accelerate the autophagic flux formation to promote carcinogenesis.…”

Section: Autophagy-inducing Lncrnas In Cancermentioning

confidence: 99%

“…The overexpression of LCPAT1 and LC3 was found to be in both LC cells and tumor samples which accelerate the autophagic flux formation to promote carcinogenesis. Whereas, knockdown of LCPAT1 can significantly reduce in vivo tumor size by reducing LC3, ATG3, ATG5, ATG7, ATG12, ATG14, and Beclin1expression (Yu et al, 2018). Chen and co-workers shown that PTENP1 is a lncRNA which is downregulated in HCC and SB based hybrid baculovirus vectors mediated insertion of PTENP1 potentially work as targeted anti-tumor agent in HCC cells by reducing proliferation and migration by activating autophagy in PI3K/AKT pathways (Chen et al, 2015).…”

Section: Autophagy-inducing Lncrnas In Cancermentioning

confidence: 99%

Autophagy-Modulating Long Non-coding RNAs (LncRNAs) and Their Molecular Events in Cancer

2019

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Cancer is a global threat of health. Cancer incidence and death is also increasing continuously because of poor understanding of diseases. Although, traditional treatments (surgery, radiotherapy, and chemotherapy) are effective against primary tumors, death rate is increasing because of metastasis development where traditional treatments have failed. Autophagy is a conserved regulatory process of eliminating proteins and damaged organelles. Numerous research revealed that autophagy has dual sword mechanisms including cancer progressions and suppressions. In most of the cases, it maintains homeostasis of cancer microenvironment by providing nutritional supplement under starvation and hypoxic conditions. Over the past few decades, stunning research evidence disclosed significant roles of long non-coding RNAs (lncRNAs) in the regulation of autophagy. LncRNAs are RNA containing more than 200 nucleotides, which have no protein-coding ability but they are found to be expressed in most of the cancers. It is also proved that, autophagy-modulating lncRNAs have significant impacts on pro-survival or pro-death roles in cancers. In this review, we highlighted the recently identified autophagy-modulating lncRNAs, their signaling transduction in cancer and mechanism in cancer. This review will explore newly emerging knowledge of cancer genetics and it may provide novel targets for cancer therapy.

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Knockdown of long non-coding RNA LCPAT1 inhibits autophagy in lung cancer

Cited by 27 publications

References 32 publications

lncRNA LCPAT1 Upregulation Promotes Breast Cancer Progression via Enhancing MFAP2 Transcription

lncRNA LCPAT1 Upregulation Promotes Breast Cancer Progression via Enhancing MFAP2 Transcription

An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer

Autophagy-Modulating Long Non-coding RNAs (LncRNAs) and Their Molecular Events in Cancer

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