Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells by Regulating MicroRNA-381

Xia, Bo; Wang, Lei; Li, Feng; Tian, Baofang; Tan, Yuanjie; Du, Baoyin

doi:10.3727/096504018x15199511344806

Cited by 19 publications

(15 citation statements)

References 35 publications

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“…For instance, lncRNA miR210HG has been shown to enhance cell invasion and metastasis by sponging miR-503 in OS (11). cAT104 has also been shown to promote OS development by sponging miR-381 (12). TUG1 knockdown also suppresses OS cell proliferation and invasion via miR-153 (13).…”

Section: Introductionmentioning

confidence: 99%

TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2

et al. 2020

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Osteosarcoma (OS) is one of the most common malignant bone tumours and generally occurs in children and adolescents. Increasing evidence has demonstrated that dysregulated long non-coding RNAs (lncRNAs) play crucial roles in the progression of various human neoplasms. Among these, tumour suppressor candidate 8 (TUSc8) is a novel lncRNA and has been reported to function as a tumour suppressor in cervical cancer. However, the exact role of TUSc8 in OS remains largely unknown. In the present study, it was observed that TUSc8 was markedly downregulated in OS tissues and cell lines. Functional experiments demonstrated that the overexpression of TUSC8 significantly suppressed the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), whereas it accelerated the apoptosis of OS cells. Mechanistically, TUSc8 served as a sponge for miR-197-3p, and EH-domain containing 2 (EHd2) was identified as a downstream target molecule of miR-197-3p. Further investigations indicated that EHD2 knockdown significantly reversed the effects on OS cellular processes induced by TUSC8 overexpression. On the whole, these findings indicate that TUSc8 functions as a competing endogenous RNA (ceRNA) to suppress OS cell growth and EMT via the miR-197-3p/EHd2 axis. TUSc8 may thus function as a potential therapeutic target in OS treatment.

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Section: Introductionmentioning

confidence: 99%

TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2

et al. 2020

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“…Li et al (42), found that actin filament-associated protein 1-AS1 promoted the proliferation and invasion of OS cells by inhibiting miRNA-4695-5p and activating Tcf4-β-catenin signaling. Xia et al (43) confirmed that inhibition of CAT104 could significantly inhibit the proliferation, migration and invasion of OS cells by regulating the expression of miR-381 and the downstream ZEB1, JNK, and Wnt/β-catenin pathways. Yang et al (44) showed that X inactive specific transcript (XIST) was upregulated in OS tissues and cells.…”

Section: Promotive Role Of Lncrnas In the Occurrence And Development mentioning

confidence: 98%

Research progress regarding the role of long non‑coding RNAs in osteosarcoma (Review)

Wang

et al. 2020

Oncol Lett

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Osteosarcoma is a malignant tumor that occurs in children and adolescents. Although treatments for osteosarcoma have improved, the likelihood of survival remains low for most patients with metastasis and recurrence. Elucidating the mechanism underlying the development of osteosarcoma and chemotherapy resistance will be important to improve diagnosis and treatment. Long non-coding RNAs (lncRNAs), which are longer than 200 nucleotides in length and do not encode for proteins, have been shown to play a regulatory role in the occurrence and development of osteosarcoma, and are expected to serve as biomarkers and molecular targets. This review discusses the progress in the study of the role of lncRNAs in osteosarcoma, and highlights the recent developments in this field. Contents

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“…CAT104 is established as an oncogene in several cancers including gastric cancer [ 87 ], leukemia [ 88 ], and osteosarcoma [ 89 ]. CAT104 was shown to be upregulated in osteosarcoma MG-63 and OS-732 cell lines, and its knockdown could restrain cell proliferation and promote apoptosis.…”

Section: Regulatory Network Of Lncrnas and Wnt Signaling Pathway In Osteosarcomamentioning

confidence: 99%

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Lin

Liu

et al. 2021

Cancer Cell Int

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Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play crucial functions in initiation, progression, therapeutic resistance, recurrence and metastasis of tumor. Considerable studies revealed a dysregulated lncRNA expression pattern in osteosarcoma, which may act as oncogenes or suppressors to regulate osteosarcoma progression. Wnt signaling pathway is an important cascade in tumorigenesis by modulation of pleiotropic biological functions including cell proliferation, apoptosis, differentiation, stemness, genetic stability and chemoresistance. Hyperactivation or deficiency of key effectors in Wnt cascade is a common event in many osteosarcoma patients. Recently, increasing evidences have suggested that lncRNAs could interplay with component of Wnt pathway, and thereby contribute to osteosarcoma onset, progression and dissemination. In this review, we briefly summarize Wnt signaling-related lncRNAs in osteosarcoma progression, aiming to gain insights into their underlying crosstalk as well as clinical application in osteosarcoma therapeutic modalities.

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Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells by Regulating MicroRNA-381

Cited by 19 publications

References 35 publications

TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2

TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2

Research progress regarding the role of long non‑coding RNAs in osteosarcoma (Review)

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

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