Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells

Zhu, Jiankang; Liu, Chongzhong; Liu, Fengyue; Wang, Yadong; Zhu, Min

doi:10.3727/096504016x14611963142218

Cited by 17 publications

(18 citation statements)

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“…Based on all the researches and findings, we concluded that the Hh signaling pathway may play a crucial role in the tumorigenesis of CRCs 4–35,40,42,47–49,53–113. Although its exact role remains controversial, the expression of the Hh pathway in CRC tissues is much higher than in normal colon tissues, especially Shh and its signaling pathway components.…”

Section: Discussionmentioning

confidence: 92%

“…Shh is now considered to likely promote formation and metastasis of CRCs 24,35. It is believed that overexpression of Shh and its downstream components is highly correlated with the formation and metastasis of CRCs, whereas it’s detailed mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…The results vary among studies: according to currently available data, while most studies showed a correlation between Hh and CRC (98 out of 101 studies), there are three researches that claimed that Hh is not, or at least not directly, related to CRC 25–27. Within the 98 studies, 92 studies confirmed upregulation effects and 5 revealed downregulation effects of the Hh pathway in CRC 4–35,40,42,47–49,53–113. Moreover, among the studies in favor of a Hh-CRC correlation, its exact function in the formation, proliferation, drug resistance, and metastasis of CRC is not uniform.…”

Section: Hh Signaling Pathwaymentioning

confidence: 99%

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Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

Zhu

Liu

et al. 2017

OTT

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Colorectal cancer (CRC) is one of the most common gastrointestinal cancers worldwide. It is a complicated and often fatal cancer, and is related to a high disease-related mortality. Around 90% of mortalities are caused by the metastasis of CRC. Current treatment statistics shows a less than 5% 5-year survival for patients with metastatic disease. The development and metastasis of CRC involve multiple factors and mechanisms. The Hedgehog (Hh) signaling plays an important role in embryogenesis and somatic development. Abnormal activation of the Hh pathway has been proven to be related to several types of human cancers. The role of Hh signaling in CRC, however, remains controversial. In this review, we will go through previous literature on the Hh signaling and its functions in the formation, proliferation, and metastasis of CRC. We will also discuss the potential of targeting Hh signaling pathway in the treatment, prognosis, and prevention of CRC.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Hh Signaling Pathwaymentioning

confidence: 99%

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Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

Zhu

Liu

et al. 2017

OTT

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“…In support of this opinion is a report that protein levels of sonic hedgehog signaling pathway components were elevated in melanosis coli, as in colorectal cancer [ 21 ]. Many evidences have demonstrated that sonic hedgehog signaling pathway was associated with development of CRC [ 22 – 24 ]. The pathogenesis of melanosis coli involves apoptosis of colonic epithelial cells caused by multiple toxic factors such as anthraquinone laxative abuse.…”

Section: Discussionmentioning

confidence: 99%

Melanosis coli: Harmless pigmentation? A case-control retrospective study of 657 cases

et al. 2017

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Backgrounds and aimsThe association of melanosis coli with the development of colorectal polyps remains uncertain.MethodsFrom a total of 18263 patients who had received colonoscopy in our hospital, 219 with melanosis coli cases and 438 controls matched by age and sex (at 1:2 ratio) were included in this study. The association of incidence, number, location, and pathology of colorectal neoplasm with grades and distribution of melanosis coli were analyzed.ResultsMelanosis coli was associated with significantly more colorectal polyps than control, a higher incidence of numerous colorectal polyps (number ≥ 20) (7.3% vs 0.5%; p < 0.001), and higher number of small colorectal polyps (diameter ≤ 5 mm; p < 0.01). Patients with melanosis coli had higher incidences of low-grade adenomas (31.1% vs 23.3%, p < 0.05) and non-adenoma polyps (20.1% vs 12.8%, p < 0.05) than the controls. On multivariate analysis, melanosis coli was independently associated with increased detecting rates of low grade adenoma (OR = 1.54; 95%: 1.06–2.23; p < .05), non-adenoma polyp (OR = 1.72; 95%: 1.11–2.70; p < .05) and numerous polyps (OR = 16.2, 95%: 3.66–71.6; p < .05). There was no significant difference in the incidence of high-grade adenomas or adenocarcinomas in the two population groups, but the numbers of these lesions were insufficient to permit firm conclusions. No significant differences in incidence, number, and pathology of colorectal polyps between individuals with melanosis coli of three different grades of severity were found. Melanosis located predominantly in the right colon had an interestingly lower incidence of colonic polyps in right colon than did melanosis located predominantly in the left colon or total colon (8.9% vs. 26.3%, 24.0%, p < 0.05). Patients with melanosis coli had significantly more nonspecific distal ileal ulcers than did controls (8.0% vs 0%, p < 0.001).ConclusionMelanosis coli is associated with a higher incidence and number of colonic non-adenoma polyps and low-grade adenomas, and higher incidence of distal ileal ulcers. Melanosis coli may not be a harmless pigmentation, but a sign of chronic injury of colonic and intestinal mucosa.

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“…69 Studies have revealed that knockdown of CDK14 in cancer cells promoted E-cadherin expression, thus suppressing EMT. 44 , 47 , 70 However, the relationship between N-cadherin and CDK14 has not been fully elucidated. As miR-216a/CDK14 axis modulated OS tumour invasiveness, we thus sought to explore the effects of miR-216a/CDK14 axis on the E-cadherin and N-cadherin production in mice.…”

Section: Discussionmentioning

confidence: 99%

miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14

Xu²,

Li³

et al. 2017

Cell Death Dis

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Osteosarcoma (OS) has emerged as the most common primary musculoskeletal malignant tumour affecting children and young adults. Cyclin-dependent kinases (CDKs) are closely associated with gene regulation in tumour biology. Accumulating evidence indicates that the aberrant function of CDK14 is involved in a broad spectrum of diseases and is associated with clinical outcomes. MicroRNAs (miRNAs) are crucial epigenetic regulators in the development of OS. However, the essential role of CDK14 and the molecular mechanisms by which miRNAs regulate CDK14 in the oncogenesis and progression of OS have not been fully elucidated. Here we found that CDK14 expression was closely associated with poor prognosis and overall survival of OS patients. Using dual-luciferase reporter assays, we also found that miR-216a inhibits CDK14 expression by binding to the 3′-untranslated region of CDK14. Overexpression of miR-216a significantly suppressed cell proliferation, migration and invasion in vivo and in vitro by inhibiting CDK14 production. Overexpression of CDK14 in the miR-216a-transfected OS cells effectively rescued the suppression of cell proliferation, migration and invasion caused by miR-216a. In addition, Kaplan–Meier analysis indicated that miR-216a expression predicted favourable clinical outcomes for OS patients. Moreover, miR-216a expression was downregulated in OS patients and was negatively associated with CDK14 expression. Overall, these data highlight the role of the miR-216a/CDK14 axis as a novel pleiotropic modulator and demonstrate the associated molecular mechanisms, thus suggesting the intriguing possibility that miR-216a activation and CDK14 inhibition may be novel and attractive therapeutic strategies for treating OS patients.

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Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells

Cited by 17 publications

References 20 publications

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

Melanosis coli: Harmless pigmentation? A case-control retrospective study of 657 cases

miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14

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