Physical activity (PA) is globally recognized as essential for overall health, particularly in preventing noncommunicable diseases among adults. However, the level of PA among adults in South East Nigeria presents a complex scenario marked by disparities and challenges. This study examines PA levels among adults in South East Nigeria, identifies barriers, and proposes strategies for improvement. Despite the World Health Organization recommendations, studies indicate that a significant portion of adults in South East Nigeria do not meet PA guidelines, with notable disparities between urban and rural areas. Recommendations include establishing community-based initiatives, increasing research efforts, leveraging health-care providers’ roles, and promoting grassroots advocacy for PA as well as involving stakeholders at all levels to create a supportive environment conducive to increased PA levels and improved public health outcomes.