Malaria is a serious infection that is transmitted by mosquitoes. It is transmitted when a person is bitten by an infected Anopheles mosquito. It effects the red blood cells and also the spleen and liver size increase as the infection deepens. Anemia or jaundice could also results from malaria. In extreme circumstances, it can target the brain and cause neurological issues. 3.3 billion peoples, or over half of the world’s population, are in danger from malaria. The frequency, signs, and causes of malaria, as well as the possible treatments, are all carefully discussed in this article. Nine medications that are used to treat malaria are employed in the quantitative structure-property relationship (QSPR) analysis. For the molecular structures of the drugs under consideration in this study, which are shown as molecular graphs, five energies are determined. There is also a statistical modeling for physio-chemical attributes with energies.